Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Effects of Grain Refinement, Eutectic Modification, and T6 Heat Treatment on Tribological Properties of Al8Si3Cu Alloys(Springer India, 2026) Gurtaran, Mikdat; Uludag, MuhammetIn this study, the effects of grain refinement and eutectic modification on the wear behaviour of Al8Si3Cu cast alloys produced both before and after degassing were investigated in detail. Grain refinement and eutectic modification were conducted by adding AlTi5B1, Al3B, and AlSr15, respectively. Following the casting process, half of the samples were T6 heat-treated to evaluate the impact of heat treatment on their wear rate. Adhesive wear testing was conducted using a steel ball under a load of 3 N, at a speed of 8 mm/s over 20 m in dry and oily mediums. Microstructural characterisation was performed using optical microscopy and scanning electron microscopy. The results revealed that grain refinement enhances wear resistance by reducing the secondary dendrite arm spacing and strengthening the aluminium matrix. Conversely, while T6 heat treatment significantly promotes the precipitation of secondary phases and intermetallic compounds, improving wear resistance, it also results in more superficial wear on T6-treated samples, which can be attributed to insufficient surface wettability during the solution treatment stage of T6 heat treatment.Article A Machine Learning Model for Predicting Oligoclonal Band Positivity Using Routine Cerebrospinal Fluid and Serum Biochemical Markers(Oxford University Press Inc, 2025) Gözgöz, Hazar; Orhan, Oğuzhan; Akan Konuk, Başak; Akan, PınarOBJECTIVE: To develop and validate a machine learning model for predicting oligoclonal band (OCB) positivity using routine cerebrospinal fluid (CSF) and serum biochemical markers to improve the diagnostic accuracy and efficiency of assessing intrathecal immunoglobulin G (IgG) synthesis. METHODS: In this retrospective study (n = 1709), an ensemble model was developed using 8 refined CSF and serum parameters. Combining optimized CatBoost, XGBoost, and LightGBM classifiers, the model was trained and evaluated using a 2-phase workflow, including 5-fold cross-validation and validation on independent internal (n = 342) and external (n = 49) cohorts. RESULTS: The developed ensemble model achieved a receiver operating characteristic-area under the curve (ROC-AUC) of 0.902 on the internal test set, significantly outperforming the conventional IgG index (ROC-AUC, 0.795). At its optimal threshold, the model demonstrated an accuracy of 0.830, with a sensitivity of 0.714 and a specificity of 0.916. On the external validation cohort, it achieved 90% accuracy and 96% sensitivity. CONCLUSIONS: A novel machine learning ensemble model accurately predicts OCB positivity using routine laboratory data and demonstrates superior performance compared with the IgG index. This approach represents a significant step in applying artificial intelligence in laboratory medicine, with the potential to enhance diagnostic efficiency. Prospective, multicenter validation is essential for broader clinical implementation. © The Author(s) 2025.Article Preparation and Characterization of Hydroxyapatite Reinforced Polymeric Scaffolds(Natl Inst Science Communication-NISCAIR, 2025) Firata, Duygu Doga; Ersoz, Su Turku; Burcu Alp, Fatma; Cetin, Ali Emrah; Ciftcioglu, MuhsinPorous HA reinforced PLA/PCL scaffolds with polymer volume percentages in the 7.0-7.6 range have been prepared by solvent-casting/salt leaching technique. The scaffolds have been characterized by conducting gravimetric measurements, FTIR analysis, TGA, X-ray diffraction analysis, compression tests, cell viability tests, and thermal and hydrolytic degradation tests in order to investigate the effect of PLA/PCL, PLA/HA, PCL/HA and PLA/PCL/HA blending on scaffold properties. Porosity of the scaffolds has been determined to be in the 83-92 percent range. The scaffold porosity has decreased with HA content. The water absorption of the scaffolds has been found to be in between 400 and 750%. The yield strength and the elastic modulus of the scaffolds have been determined to be in the 0.001-0.02 and 5.6-10.6 MPa ranges, respectively. The yield strength of the scaffolds has increased by both PCL and HA contents whereas elastic modulus has increased with PCL content but has decreased with HA content. Mechanical test results have indicated that the addition of HA has increased the strength of the scaffolds while decreasing their flexibility. The activation energies for the thermal degradation of the scaffolds have been determined to be in the 130-398 kJ/mol range and have been shown to be a function of PCL, PLA, and HA content. The hydrolytic degradation behavior of the scaffolds in acetate buffer solutions (pH=4.5) during 127 days and XRD analysis have indicated that the hydrolytic degradation occurring in the amorphous part of the surface film has been diffusion-controlled. The diffusion coefficients of the degradation products in the scaffolds have been estimated to be in the 1.21-4.95x10(-13) m(2)/s range. Cell viability test results have indicated that the composition of the composite scaffold structure has played a determining role in the prepared scaffolds.Article Citation - WoS: 1Citation - Scopus: 1Experimental Investigation of Naca 4415 Airfoil Using Vibration Data for Stall Detection(Emerald Group Publishing, 2023) Ayaz Ümütlü, Hatice Cansu; Kıral, Zeki; Karadeniz, Ziya HaktanPurposeThe purpose of this study is to identify the possible relation between the vibration and the stall by using the vibration response of the airfoil. For this purpose, the root mean square values of the acceleration signals are evaluated to demonstrate the compatibility between the stall angles and the vibration levels. Design/methodology/approachAn experimental study is conducted on NACA 4415 airfoil at Reynolds numbers 69e3, 77e3 and 85e3. Experiments are performed from 0 & DEG; to 25 & DEG; of the angles of attack (AoA) for each Reynolds number condition. To observe the change of the vibration values at the stall region clearly, experiments are performed with the AoA ranging from 10 & DEG; to 25 & DEG; in 1 & DEG; increments. Three acceleration sensors are used to obtain the vibration data. FindingsThe results show that the increase in the amplitude of the vibration is directly related to the decrease in lift. These findings indicate that this approach could be beneficial in detecting stall on airfoil-type structures. Originality/valueThis study proposes a new approach for detecting stall over the airfoil using the vibration data.Article Assessment of Undergraduate Health Students' Perception and Satisfaction on Training and Participation in Community Health Outreach(Springer, 2023) Adegbore, Abidemi Kafayat; Adedokun, Amudatu Ambali; Adegoke, Juliet Ifeoluwa; Lawal, Maruf Ayobami; Oke, MuseAimThe need to improve training of health professionals has increased in recent years due to increasing frequencies of public health events. Consequently, a descriptive cross-sectional survey was carried out to determine the level of satisfaction and knowledge acquired by undergraduate students in the health sciences during a community health outreach program.Subject and methodsStudents were invited to complete an online-administered questionnaire (consisting of both open- and closed-ended questions) to assess their perceptions and experiences on the community health outreach program. Additionally, the survey was carried out to assess the quality of training provided and obtain suggestions for further improvements. Responses were collected and analysed using Microsoft Excel.ResultsMost respondents (>83%) reported satisfaction with the community diagnosis and community intervention briefing and training sessions. All respondents reported familiarity with standard community health outreach instruments and were capable of identifying environmental health risk factors that may contribute to the spread of communicable diseases. Interestingly, respondents reported greater appreciation of health challenges faced by rural communities. However, respondents expressed dissatisfaction with the duration of the outreach program (24%) and funding (15%).ConclusionAlthough respondents reported overall satisfaction with the organization and execution of the health outreach program, certain aspects of the program were deemed unsatisfactory. Despite the shortcomings, we believe that our student-centred learning strategy is readily adaptable for training future healthcare professionals and improving health literacy of rural communities, particularly in sub-Saharan Africa.Article Citation - WoS: 8Citation - Scopus: 9Experimental Investigation of Air Cooling With/Out Tab Cooling in Cell and Module Levels for Thermal Uniformity in Battery Packs(ASME, 2023) Göçmen, Sinan; Çetkin, ErdalCatastrophic effects of global warming and environmental pollution are becoming more evident each day, and reduction in fossil fuel consumption is an urgent need. Thus, electric vehicles powered by sustainable energy sources are becoming a major interest. However, there are some challenges such as safety, limited range, long charging times, and battery life which are inhibitory to the adaptation of them. One of the biggest reasons for these challenges is the relationship between battery degradation and temperature which can be eliminated if batteries can be kept at the optimum temperature range. Here, the effects of three distinct (natural convection, forced convection, and tab cooling) methodology were experimentally compared at both the cell and module levels (six serial 7.5 Ah Kokam pouch cells, 1P6S) for thermal management of lithium-ion cells. The experiments were conducted at a discharge rate of 3C with ambient temperatures of 24 ◦C and 29 ◦C. The cell-level test results show that the tab cooling yields 32.5% better thermal uniformity in comparison to the other techniques. Furthermore, tab cooling yields better temperature uniformity with and without air convection as the hot spots occurring near the tabs is eliminated. For the module level, the forced air convection method stands out as the best option with a 4.3% temperature deviation between cells and maximum cell temperature of 39 ◦C. Overall, the results show that a hybrid approach with tab cooling would be beneficial in terms of temperature homogeneity especially in high capacity electric vehicle battery cells.Article Citation - WoS: 12Citation - Scopus: 13A General Expression for the Stagnant Thermal Conductivity of Stochastic and Periodic Structures(The American Society of Mechanical Engineers(ASME), 2018) Bai, X.; Çelik, Hasan; Mobedi, Moghtada; Nakayama, AkiraA general expression has been obtained to estimate thermal conductivities of both stochastic and periodic structures with high-solid thermal conductivity. An air layer partially occupied by slanted circular rods of high-thermal conductivity was considered to derive the general expression. The thermal conductivity based on this general expression was compared against that obtained from detailed three-dimensional numerical calculations. A good agreement between two sets of results substantiates the validity of the general expression for evaluating the stagnant thermal conductivity of the periodic structures. Subsequently, this expression was averaged over a hemispherical solid angle to estimate the stagnant thermal conductivity for stochastic structures such as a metal foam. The resulting expression was found identical to the one obtained by Hsu et al., Krishnan et al., and Yang and Nakayama. Thus, the general expression can be used for both stochastic and periodic structures.Article Citation - WoS: 31Citation - Scopus: 33Modification of Carbon Fibre/Epoxy Composites by Polyvinyl Alcohol (pva) Based Electrospun Nanofibres(Adcotec Ltd., 2016) Beylergil, Bertan; Tanoğlu, Metin; Aktaş, EnginIn this study, the effects of modifying interlaminar region of unidirectional carbon fibre/epoxy composites by the incorporation of electrospun polyvinyl alcohol (PVA) nanofibres were investigated. PVA nanofibres were directly deposited onto the carbon fabrics by electrospinning method to improve mechanical performance of those composites. The features of the electrospun nanofibres were characterized by microscopy techniques. The unidirectional carbon fibre/epoxy composite laminates with/without PVA nanofibre interlayers were manufactured by vacuum-infusion technique in a [0]4 configuration. Tensile, three-point bending, compression, Charpy-impact and Mode-I fracture toughness tests (Double Cantilever Beam (DCB)) were carried out in accordance with ASTM standards to evaluate mechanical performance of the composites. Scanning electron microscopy (SEM) observations were made on the specimens to evaluate microstructural features. It was observed that the carbon fabrics were successfully coated with a thin layer of PVA nanofibres by electrospinning technique. The results showed that P VA nanofibres improve the mechanical properties of unidirectional carbon/epoxy composite laminates when subjected to in-plane loading. On the other hand, PVA nanofibres slightly reduced the mode-I fracture toughness values although they led to more stable crack propagation.Article Citation - WoS: 10Citation - Scopus: 10Constructal Microdevice Manifold Design With Uniform Flow Rate Distribution by Consideration of the Tree-Branching Rule of Leonardo Da Vinci and Hess-Murray Rule(The American Society of Mechanical Engineers(ASME), 2017) Çetkin, ErdalIn this paper, we show how the design of a microdevice manifold should be tapered for uniform flow rate distribution. The designs based on the tree-branching rule of Leonardo da Vinci and the Hess-Murray rule were considered in addition to the constructal design. Both da Vinci and Hess-Murray designs are insensitive to the inlet velocity, and they provide better flow uniformity than the base (not tapered) design. However, the results of this paper uncover that not only pressure drop but also velocity distribution in the microdevice play an integral role in the flow uniformity. Therefore, an iterative approach was adopted with five degrees-of-freedom (inclined wall positions) and one constraint (constant distribution channel thickness) in order to uncover the constructal design which conforms the uniform flow rate distribution. In addition, the effect of slenderness of the microchannels (Svelteness) and inlet velocity on the flow rate distribution to the microchannels has been documented. This paper also uncovers that the design of a manifold should be designed with not only the consideration of pressure distribution but also dynamic pressure distribution especially for non-Svelte microdevices.Article The Aggregatibacter Actinomycetemcomitans Heat Shock Protein Groel Interacts Directly With Human Peripheral Blood T Cells(TÜBİTAK, 2016) Nalbant, Ayten; Saygılı, TahsinHeat shock family protein GroEL of Aggregatibacter actinomycetemcomitans (Aa) has antigenic properties. We previously demonstrated that A. actinomycetemcomitans GroEL-like protein affects human CD4 T cells by converting them into IL-10 and IFNg double cytokine producing Tbet+ Th1 cells. The objective of this study was to investigate whether or not AaGroEL communicates with T cells directly. To do this, sorted cells from peripheral blood mononuclear cells were stimulated with AaGroEL for 48 h. Flow cytometry was used to measure soluble and intracellular cytokine expression in the cell cultures and detect TLR2 expression on the surface of T cells. Expression of six different soluble cytokines was evaluated by CBA assay. To determine whether AaGroEL affects CD3+ T cells directly or not, purified CD3+ T cells or CD14+ cells were cultured with AaGroEL separately, and the quantity of soluble cytokine was measured. Results showed that sorted CD3+ cells produced soluble IL-6, TNFα-and IFNγ cytokines. Additionally, the intracellular cytokine staining data showed that AaGroEL-stimulated CD3+ cells were also TNFα-and IFNγ-positive. Moreover, AaGroEL-responsive T cells slightly increased their TLR2 expression. These findings suggest that CD3+ T cells produce cytokines in response to AaGroEL protein without requirements for other cells, such as CD14+ monocytes.