Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - Scopus: 11Chemical Composition and Biological Activities of Cypriot Propolis(Taylor and Francis Ltd., 2022) Nalbantsoy, A.; Sarıkahya, N.B.; Özverel, C.S.; Barlas, A.B.; Kırcı, D.; Akgün, İ.H.; Yalçın, Tansel; Düven, GamzePropolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. α-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36–11.56 µg/mL; 1.44–9.33 µg/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 µg/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 ± 0.10%) and antimicrobial activities (with a MIC value of 31.2 μg/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis). © 2021 International Bee Research Association.Article Citation - WoS: 9Citation - Scopus: 9The Tourism Potential of Post-Mining Heritage Sites: The Cyprus Mining Cooperation in Lefka, Cyprus(Springer, 2022) Oktay Vehbi, Beser; Mısırlısoy, Damla; Günçe, Kağan; Yüceer, HülyaThe mining sites have geo-scientific, industrial, cultural, aesthetic, economic, historic and anthropological potentials for the development of tourism. Lefka with an ancient history of mining and having rich geodiversity as well as various historical and cultural monuments, archaeological sites along with poor economic conditions can develop tourism with mining tourism goals. The study aims to examine the tourism potential of post-mining heritage sites as part of a strategic approach and tool for planning that encourages local development through the case of the Cyprus Mining Cooperation (CMC), a derelict copper mining field in Lefka, North Cyprus. Established during the British administration of the island, CMC covers a large area that comprises of mine fields, processing units, laboratories, workers houses and other related public buildings serving the whole complex, which were left derelict about sixty years ago. The study presents the values—scientific, aesthetic, economic, historical and cultural—associated with the site and its components, the criteria for their conservation and reuse opportunities for tourism purposes. Conservation strategies are suggested within the framework of ‘mining tourism’ to present the heritage significance of the site.Article Citation - WoS: 7Citation - Scopus: 11Chemical Composition and Biological Activities of Cypriot Propolis(Taylor and Francis Ltd., 2021) Nalbantsoy, Ayşe; Sarıkahya, Nazlı Böke; Özverel, Cenk Serhan; Barlas, Ayşe Berçin; Kırcı, Damla; Akgün, İsmail Hakkı; Yalçın, Tansel; Güven, Gamze; Kışla, Duygu; Demirci, Betül; Topçu, Gülaçtı; Gören, Ahmet CeyhanPropolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).