Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Comparative Optimization of Hot Water and Citric Acid Extraction Methods for Sericin Recovery From Silk Cocoons: In Vitro Antioxidant and Antidiabetic Activities(Springer, 2026) Sincar, Bahar; Ozdemir, Feyza; Bicakci, Beyza Tutku; Erdem, Cansu; Yalcin, Dilek; Alamri, Abdulhakeem S.; Bayraktar, OguzSilk sericin, a hydrophilic protein derived from Bombyx mori cocoons, has attracted increasing interest due to its antioxidant, moisturizing, and enzyme-inhibitory properties. Efficient extraction is essential to preserve its biofunctional potential. In this study, sericin was extracted using hot water and 1.25% (w/v) citric acid using autoclave-based heating to achieve pressurized conditions above 100 degrees C. A Box-Behnken Response Surface Methodology (RSM) was applied to systematically evaluate the effects of extraction parameters (temperature and time) and to optimize five key response variables: yield, purity, molecular weight and polydispersity index (PDI), total antioxidant capacity (ABTS), and alpha-glucosidase inhibition activity. The results revealed that higher temperatures (125 degrees C) produced the maximum sericin yield, while moderate conditions (115 degrees C for 45 min) ensured better preservation of antioxidant and antidiabetic activities. Hot acid extraction resulted in significantly enhanced purity and enzymatic inhibition compared to hot water extraction. Sericin fractions above 7 kDa exhibited the strongest bioactivity, as reflected by lower IC50 values in both ABTS and alpha-glucosidase inhibition assays. The optimized hot water citric acid-based method yielded 24.00% sericin with 100.00% purity and an IC50 of 0.67 mg/mL for alpha-glucosidase inhibition. This study compares hot water and hot acid autoclave extractions using Box-Behnken design and evaluates their effects on sericin yield, purity, and bioactivities. Citric acid-based extraction produced higher purity and stronger alpha-glucosidase inhibition, while hot water extraction preserved antioxidant potential more effectively. These findings support the use of citric acid as an eco-friendly and scalable extraction agent and highlight the potential of sericin in biomedical and nutraceutical applications.Article Citation - WoS: 3Citation - Scopus: 3Shelf-Life Extension of Traditional Licorice Root “sherbet” With a Novel Pulsed Electric Field Processing(Frontiers Media S.A., 2023) Akdemir Evrendilek, Gulsun; Demir, Irem; Uzuner, SibelPulsed electric field (PEF) processing of licorice root "sherbet" (LRS) by various electric field strengths (7.00, 15.50, and 24.10 kV/cm), treatment times (108, 432, and 756 mu sec), and processing temperatures (6, 18, and 30 degrees C) according to the Box-Behnken design were performed. The samples were analyzed for pH, titratable acidity, conductivity, turbidity, total reducing sugar, color (L*, a*, and b*), hue, chroma, total color difference, color intensity, color tone (yellow, red, and blue color tones), total antioxidant capacity, total phenolic substance content, and sensory properties. Results revealed that PEF processing did not adversely affect most of the physical, chemical, and sensory properties of LRS, with a maximum of 2.48, 4.04, 1.78, and 1.20 log reductions on the initial total mesophilic aerobic bacteria, total mold and yeast, Bacillus circulans, and Candida tropicalis. The response variable modeled for the PEF was found to be conductivity, with the optimum processing conditions of 6.90 kV/cm, 756.00 mu s, and 7.48 degrees C. After that, the samples were stored at 4 degrees C and 22 degrees C for shelf-life studies. Control samples at 4 degrees C and 22 degrees C were spoiled on the fifth and second days, whereas PEF-treated samples stored at 4 degrees C began to deteriorate after the 40th day and the samples stored at 22 degrees C after the 30th day, respectively. It was revealed that PEF is a suitable process to extend the shelf-life of licorice "sherbet" with preservation of physicochemical and sensory properties.Article Citation - Scopus: 8Optimal Design of the Type Iii Hydrogen Storage Tank for Different Carbon/Epoxy Materials by Modified Differential Evolution Method(MIM RESEARCH GROUP, 2019) Ayakdaş,O.; Aydın,L.; Savran,M.; Küçükdoğan,N.; Öztürk,S.In this study, the main objective is to minimize the failure index of a cylindrical laminated composite hydrogen storage tank under internal pressure. The first step is to obtain the distribution of stress components based on Classical Laminated Plate Theory (CLPT). The second is to evaluate the burst pressure of the tank according to three different first ply failure criteria and then to compare the results with the experimental and numerical ones from literature. In the final part of the study, the best possible combination of winding angles, stacking sequences and thicknesses of laminates satisfying minimum possible stress concentration will be obtained for different Carbon/Epoxy materials by Differential Evolution Method. The stress components and, the burst pressures reached according to Hashin-Rotem, Maximum Stress, and Tsai-Wu first-ply failure criteria, have been complied with experimental and numerical results in the literature for Type III pressure vessels. Manufacturable Type-III tank designs have been proposed satisfying the 35 MPa burst pressure for different Carbon/Epoxy materials. © 2019 MIM Research Group. All rights reserved.Book Part Citation - Scopus: 1A New Stable Solar System for Electricity, Cooling, Heating, and Potable Water Production in Sunny Coastal Areas(Springer, 2023) Khani, Leyla; Mohammadpourfard, MousaNowadays, more attention is paid to provide clean energy products with low environmental pollution in a decentralized way. Many coastal rural areas suffer from freshwater and electricity scarcity, especially in hot weather condition. Meanwhile, these regions have a great access to intense solar radiation and seawater. Hence, it seems logical to use the available solar energy in those places to provide to necessities like power, heating, and cooling. A new solar cooling, power, heating, and freshwater production system is designed, evaluated, and optimized in this research. The proposed system is composed of several subsystems to generate each product with high efficiency and reliability. Solar energy is unavailable at night, so molten salt energy storage is used to establish the steady operation of the system. Then, the system is evaluated from thermodynamic and exergoeconomic viewpoints, and a parametric study is accomplished to study the effect on the system performance of key variables. In the end, the system is optimized to determine its best operating condition for different cases. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.Article Citation - WoS: 26Citation - Scopus: 34Arsenite Removal From Groundwater in a Batch Electrocoagulation Process: Optimization Through Response Surface Methodology(Taylor & Francis, 2019) Şık, Emrah; Gören, Ayşegül Yağmur; Demirbaş, Erhan; Kobya, Mehmet; Öncel, Mehmet SalimIn this study, influences of seven process variables such as initial pH (pH(i)), applied current (i), operating time (t(EC)), initial As(III) concentration (C-o), diameter of Fe ball anode (d(p)), column height in the electrocoagulation (EC) reactor (h) and airflow rate (Q(air)) for removal of As(III) from groundwater by a new air-fed fixed-bed EC reactor were evaluated with a response surface methodology (RSM). The proposed quadratic model fitted very well with the experimental data for the responses. The removal efficiencies and operating costs were determined to be 99% and 0.01 $/m(3) at the optimum operating conditions (a pH(i) of 8.5, 0.05 A, 4.94 min, d(p) of 9.24 mm, h of 7.49 cm, Q(air) of 9.98 L/min for 50 mu g/L). This study clearly showed that the RSM in the EC process was a very suitable method to optimize the operating conditions at the target value of effluent As(III) concentration (10 mu g/L) while keeping the operating cost to minimal and maximize the removal efficiency.Article Citation - WoS: 4Citation - Scopus: 5Combined Influence of Some Cations on Arsenic Removal by an Air-Injection Ec Reactor Using Aluminum Ball Electrodes(Desalination Publications, 2020) Gören, Ayşegül Yağmur; Kobya, Mehmet; Şık, Emrah; Demirbaş, Erhan; Öncel, Mehmet SalimCombined effects of some cations such as calcium (Ca2+), iron (Fe2+), manganese (Mn2+), and magnesium (Mg2+) and operating time on the removal of arsenic by air-injected electrocoagulation (EC) reactor with aluminum (Al) ball electrodes were investigated. The operating conditions were optimized with the Box-Behnken design of response surface methodology (RSM). The response variables were selected from the program as removal efficiency, residual arsenic concentration, energy consumption and operating cost (OC) in the EC process. A total of 46 experimental run was performed. The removal efficiency of arsenic increased with an increase in iron concentration (0.5-4.5 mg/L). The rest of the cations showed no noticeable effect on arsenic removal efficiency. The maximum arsenic removal efficiency and minimum OC at the optimum operating conditions (C-Ca: 305 mg/L, C-Mg: 42 mg/L, C-Fe: 3.3 mg/L, C-Mn: 2.34 mg/L, initial pH of 7.5 applied current of 0.15 A, Al ball size of 7.5 mm, 5.0 cm of Al ball anodes height in the EC reactor, air-fed rate of 6.0 L/min and t(EC): 16.83 min) in the EC process were 99.9% and 0.0332 $/m(3) for initial arsenic concentration of 200 mu g/L, respectively. The removal mechanism of As(III) by EC seems to be oxidation of As(III) to As(V) and subsequent removal by adsorption/complexation with aluminum hydroxides generated in the process. The results showed that the air-injected EC reactor can be used effectively for arsenic and hardness removal simultaneously from real groundwater sources.