Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

Browse

Filters

2002 - 200912020 - 20241

Settings

Scopus Q: search.filters.scopusQuartile.Q4Subject: search.filters.subject.Calcium phosphate

Search Results

Now showing 1 - 2 of 2
  • Article
    Proliferative Effects and Cellular Uptake of Ceramic Nanoparticles in Cancer and Normal Cells
    (Univ Chemistry & Technology, Prague, 2024) Cesmeli, Selin; Tomak, Aysel; Winkler, David A.; Karakus, Ceyda Oksel
    The high biocompatibility, wear resistance, and high surface area-to-volume ratios of calcium phosphate (CaP) nanoparticles make them materials of great interest for a very broad range of medical applications, such as dentistry, drug delivery, biomedical imaging, gene transfection and silencing, biomedical imaging, immunisation, and bone substitution. While their use as an enamel remineralisation agent, a bone substitution material, an implant coating, and drug/gene delivery agents is widely approved by the regulating bodies, insufficient attention has been paid to the interactions of CaP-based nanoparticles with cells and organs once in the bloodstream and distributed through the body. Here, three different CaP-based nanoparticles (CP: calcium phosphate, TCP: tricalcium phosphate, and HAp: hydroxyapatite) were examined for the proliferative effects, oxidative damage potential, and cellular uptake in the human embryonic kidney (HEK293) and pancreatic cancer (Panc-1) cell lines. The physicochemical properties of the nanoparticles were characterised by Teller analysis, and X-ray diffraction spectroscopy. Maximum proliferative effects were generated by 400 mu g center dot ml-1 TCP (220 %) in HEK293 cells. Interestingly, although CP nanoparticles had the highest reactive oxygen species formation capacity in the HEK293 cells, they exhibited the lowest proliferative effects and a relatively low internalisation rate, suggesting a minimal correlation between the cellular uptake level and oxidative potential.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Tensile Adhesion of Type I Collagen To Titanium Alloy and Calcium Phosphate Coated Surfaces With Different Roughness Values
    (IOS Press, 2002) Özerdem, Barış
    The purpose of total joint arthroplasty is to reduce pain and restore function. Its success depends on the formation of a new bone that stabilizes the prosthesis. The proposed solution for this important problem is to have bio-coated implant surfaces which are more conductive to bone growth. Additionally, collagen has long been used as a matrix for medical applications, because of its biocompatibility and adaptability. In this study, a test method for measuring the tensile adhesion strength of collagen to titanium alloy and calcium phosphate coated surfaces with different roughness values was developed, in order to evaluate how well the collagen adheres to the metallic and bio-coated surfaces. A precision motion system was used to stretch gels that were adherent to the plate surfaces. The tests were done in DMEM solution. The adhesive strength between the collagen gel and plate was significantly higher for calcium phosphate coated surfaces. Adhesive strength was highest in the sample with the highest roughness value.