Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Review Citation - WoS: 1Citation - Scopus: 2Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling(Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, ErdalOrgans-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.Article Introducing Engineering Students To Microfluidics and 3d Printing Using Hands-On Activities(American Society for Engineering Education, 2023) Dogan, E.; Borgaonkar, A.D.; Nafisi, N.; Miri, A.K.Microfluidics technology involves the regulation of flow in micron-sized channels for desired reactions, with applications in biological modeling, drug manufacturing, screening of biological agents, and various engineering fluid dynamics-related purposes. Despite its growth and development, microfluidics has not been widely included as a teaching topic in undergraduate engineering education. This manuscript presents a hands-on project-based learning approach that can be easily implemented into core engineering courses, such as fluid mechanics, transport, chemical reactions, and others. Project-based activities presented here have three main parts: material preparation based on synthetic polymers, light-assisted manufacturing of a microfluidic device, and mass transport experiments to observe the fluid behavior. The project leverages 3D printing and the potential to connect students with makerspaces and 3D printing and to get them started on the path to bringing their ideas to life. The paper includes a breakdown of how to access and evaluate these activities. As a result of this hands-on activity, students will understand how fluid mechanics concepts are applied to microfluidics. Students will also learn about a novel interdisciplinary field that is growing rapidly. Engineering technology students will benefit from exposure to the application side of this emerging field through these lab-style activities that they are accustomed to in the majority of their core courses. Finally, the authors hope that such successful integration will encourage faculty to introduce other novel science and engineering topics that are currently only accessible through research experiencebased courses. © 2023, American Society for Engineering Education. All rights reserved.