Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Conference Object Citation - Scopus: 14Mechanical Investigation for the Use of Polylactic Acid in Total Hip Arthroplasty Using Fem Analysis(Springer, 2022) Çelik, Emre; Alemdar, Furkan; Batı, Murat; Daşdemir, Muhammed Furkan; Büyükbayraktar, Onur Alp; Chethan, K.N.; Mihçin, ŞenayPolylactic acid (PLA) is a biodegradable non-toxic, biocompatible polymer used as a popular filament material in biomedical applications with the advance of 3D printing technologies. PLA is considered a suitable implant material due to its contribution to bone regeneration. In this study, the use of PLA in Total Hip Arthroplasty (THA) as a liner material was assessed. In this regard, the PLA liner with different material combinations in THA was examined to provide evidence for its potential. The hip implant prototypewas drawn using a computer-aided design tool then transferred into a commercial finite element analysis (FEA) software. The prototypesconsisted of assemblies of PLA with titanium, chrome cobalt, stainless steels, dense NiTi shape-alloys, and Alumina-Zirconia. Simulations were run under static loading conditions. To evaluate and compare the results for the optimum design; factor of safety, total deformation and von Mises stress analysis were used. The results show that Co-Cr implemented implants produce the highest factor of safety. When Al-Zi combined with PLA, it produced least deformation and reasonable von- Mises stress values. PLA might perform best when used with Al-Zi. As a next step, experimental pre-clinical tests are planned to assess the clinical potential. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.Article Citation - WoS: 61Citation - Scopus: 64Electrospun Gelma Fibers and P(hema) Matrix Composite for Corneal Tissue Engineering(Elsevier Ltd., 2021) Arıca, Tuğçe A.; Güzelgülgen, Meltem; Yıldız, Ahu Arslan; Demir, Mustafa MuammerThe development of biocompatible and transparent three-dimensional materials is desirable for corneal tissue engineering. Inspired from the cornea structure, gelatin methacryloyl-poly(2-hydroxymethyl methacrylate) (GelMA-p(HEMA)) composite hydrogel was fabricated. GelMA fibers were produced via electrospinning and covered with a thin layer of p(HEMA) in the presence of N,N?-methylenebisacrylamide (MBA) as cross-linker by drop-casting. The structure of resulting GelMA-p(HEMA) composite was characterized by spectrophotometry, microscopy, and swelling studies. Biocompatibility and biological properties of the both p(HEMA) and GelMA-p(HEMA) composite have been investigated by 3D cell culture, red blood cell hemolysis, and protein adsorption studies (i.e., human serum albumin, human immunoglobulin and egg white lysozyme). The optical transmittance of the GelMA-p(HEMA) composite was found to be approximately 70% at 550 nm. The GelMA-p(HEMA) composite was biocompatible with tear fluid proteins and convenient for cell adhesion and growth. Thus, as prepared hydrogel composite may find extensive applications in future for the development of corneal tissue engineering as well as preparation of stroma of the corneal material. © 2020 Elsevier B.V.