Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

Browse

Filters

2023 - 20243

Settings

Subject: search.filters.subject.BiomaterialsWoS Q: search.filters.wosQuartile.Q2

Search Results

Now showing 1 - 3 of 3
  • Article
    Citation - WoS: 8
    Citation - Scopus: 9
    Enhancing Wound Regeneration Potential of Fibroblasts Using Ascorbic Acid-Loaded Decellularized Baby Spinach Leaves
    (Springer, 2024) Dikici, Serkan
    Decellularization of plant tissues is an emerging route to fabricate scaffolds for tissue engineering and regenerative medicine. Although significant progress has been made in the field of plant tissue decellularization, functionalization of plant scaffolds is still an emerging field, and loading them with L-ascorbic acid to promote skin regeneration has not yet been reported. L-ascorbic acid is an antioxidant that plays a key role in collagen synthesis as a cofactor of lysyl hydroxylase and prolyl hydroxylase. It has been shown to have significant importance in physiological wound healing by stimulating fibroblasts to produce collagen at both the molecular and the genetic levels. In this work, we aimed to fabricate an ascorbic acid-releasing bioactive scaffold by introducing a stable form of ascorbic acid, L-ascorbic acid 2-phosphate (AA2P), into decellularized baby spinach leaves and investigated its biological activity in vitro. Our results demonstrated that AA2P could be easily introduced into decellularized baby spinach leaf scaffolds and subsequently released within the effective dose range. AA2P-releasing baby spinach leaves were found to increase metabolic activity and enhance collagen synthesis in L929 fibroblasts after 21 days. In conclusion, this study demonstrated the fabrication of a novel functionalized skin tissue engineering scaffold and made a significant contribution to the fields of plant decellularization and skin tissue engineering.
  • Review
    Citation - WoS: 17
    Citation - Scopus: 16
    Engineering Periodontal Tissue Interfaces Using Multiphasic Scaffolds and Membranes for Guided Bone and Tissue Regeneration
    (Elsevier, 2024) Özkendir, Özge; Karaca, İlayda; Çullu, Selin; Yaşar, Hüsniye Nur,; Erdoğan, Oğulcan; Dikici, Serkan; Dikici, Betul Aldemir
    Periodontal diseases are one of the greatest healthcare burdens worldwide. The periodontal tissue compartment is an anatomical tissue interface formed from the periodontal ligament, gingiva, cementum, and bone. This multifaceted composition makes tissue engineering strategies challenging to develop due to the interface of hard and soft tissues requiring multiphase scaffolds to recreate the native tissue architecture. Multilayer constructs can better mimic tissue interfaces due to the individually tuneable layers. They have different characteristics in each layer, with modulation of mechanical properties, material type, porosity, pore size, morphology, degradation properties, and drug-releasing profile all possible. The greatest challenge of multilayer constructs is to mechanically integrate consecutive layers to avoid delamination, especially when using multiple manufacturing processes. Here, we review the development of multilayer scaffolds that aim to recapitulate native periodontal tissue interfaces in terms of physical, chemical, and biological characteristics. Important properties of multiphasic biodegradable scaffolds are highlighted and summarised, with design requirements, biomaterials, and fabrication methods, as well as post-treatment and drug/growth factor incorporation discussed.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 6
    Investigation of the Influence of High-Pressure Torsion and Solution Treatment on Corrosion and Tribocorrosion Behavior of Cocrmo Alloys for Biomedical Applications
    (MDPI, 2023) Yılmazer, Hakan; Caha, İhsan; Dikici, Burak; Toptan, Fatih; Işık, Murat; Niinomi, Mitsuo; Nakai, Masaaki; Alves, Alexandra Cruz
    In this study, the influence of the high-pressure torsion (HPT) processing parameters and solution treatment (ST) on the corrosion and tribocorrosion behavior of CoCrMo (CCM) alloys was investigated for possible usage in biomedical applications. The corrosion behavior of the CCM alloys was investigated by using potentiodynamic scanning (PDS) and electrochemical impedance spectroscopy (EIS) tests. Tribocorrosion tests were carried out in a reciprocating ball-on-plate tribometer at 1 Hz, 1 N load, and 3 mm stroke length for 2 h. All electrochemical measurements were performed using a potentiostat in standard phosphate-buffered saline (PBS) solution at body temperature (37 +/- 2 degrees C). The samples were characterized by using a scanning electron microscope (SEM), transmission electron microscope (TEM), optical microscope (OM), and X-ray diffraction (XRD). The deepness and width of wear tracks were examined by using a profilometer. The results showed that HPT and ST processes did not affect significantly the corrosion resistance of samples. However, the ST-treated samples had a higher material loss during sliding in standard phosphate-buffered saline (PBS) at body temperature as compared to HPT-treated samples.