Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - Scopus: 2Flavonoids as Chemosensitizers in Leukemias(2025) Huseynova, N.; Çetinkaya, M.; Baran, Z.; Khalilov, R.; Mammadova, A.; Baran, Y.Flavonoids, a diverse group of natural compounds abundant in plants, fruits, and seeds, are not only responsible for the vibrant colors, fragrances, and flavors found in nature but also possess significant health benefits. Representing a secondary metabolite, these phytonutrients contribute to overall well-being. They have garnered considerable interest due to their diverse biological roles, encompassing antioxidant, anti-inflammatory, and anticancer properties. Flavonoids exert anticancer properties by interfering with different signaling pathways and molecules. Also, they have been demonstrated to exert chemosensitization features, where flavonoids may enhance the effectiveness of chemotherapy, and hold promise for improving cancer treatment outcomes as they have been discovered to make cancer cells more responsive to treatment. Understanding their influence on the regulation of cellular signaling provides a foundation for exploring their potential in combination with different chemotherapy agents and their possible single use for cancer treatment. Besides, they are believed to present a cost-effective approach to cancer therapeutics with possible implications for reducing the side effects of the current chemotherapy regimens, which can be a great therapeutic strategy for treating cancer types, including leukemia. This chapter explores potential approaches for creating anticancer treatments, focusing on leukemia, through integrating flavonoid nutraceuticals with traditional chemotherapy agents. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.Book Part Citation - Scopus: 20Flavonoids in Cancer Therapy: Current and Future Trends(Elsevier, 2020) Gürler,S.B.; Kiraz,Y.; Baran,Y.Flavonoids are a family of polyphenolic photochemical that are naturally found in plants. Flavonoids have been widely studied due to the curiosity of scientists about the implementation of nature to human health. These experimental and epidemiological studies showed that flavonoids have beneficial effects such as antioxidation, antiinflammation, antiplatelet, antiallergic, antiaging, antidiabetic, and anticarcinogenic activity. They can also interact with and regulate cellular proteins, transcription factors, and signaling enzymes at the molecular level. Cancer is one of the most common problems in human health and millions of people die due to cancer every year. Due to the lack of completely efficient therapies for most cancer patients, new approaches should be discovered. Flavonoids have been investigated and many studies have confirmed their importance as a therapy option in many diseases. In this chapter we review the use of flavonoids as therapeutical agents and prevention for cancer, including the recent studies as well as future perspectives in the field. © 2020 Elsevier Inc. All rights reserved.Review Citation - WoS: 96Citation - Scopus: 112Therapeutic Potential of Luteolin on Cancer(MDPI, 2023) Çetinkaya, Melisa; Baran, YusufCancer is a global concern, as the rate of incidence is increasing each year. The challenges related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to cancer therapeutic research to discover alternative therapy strategies that are less toxic to normal cells. Among those studies, the use of flavonoids-natural compounds produced by plants as secondary metabolites for cancer therapy-has been a hot topic in cancer treatment. Luteolin, a flavonoid that has been present in many fruits, vegetables, and herbs, has been identified to exhibit numerous biological activities, including anti-inflammatory, antidiabetic, and anticancer properties. The anticancer property of Luteolin has been extensively researched in many cancer types and has been related to its ability to inhibit tumor growth by targeting cellular processes such as apoptosis, angiogenesis, migration, and cell cycle progression. It achieves this by interacting with various signaling pathways and proteins. In the current review, the molecular targets of Luteolin as it exerts its anticancer properties, the combination therapy that includes Luteolin with other flavonoids or chemotherapeutic drugs, and the nanodelivery strategies for Luteolin are described for several cancer types.Conference Object Citation - Scopus: 2Utilization of Near Ir Absorbing Gold Nanocolloids by Green Synthesis(Trans Tech Publications, 2018) Elveren, Beste; Yıldız, Ümit Hakan; Arslan Yıldız, AhuThe rapid developments in nanoscience, and its applications on biomedical areas have a large impact on drug delivery, tissue engineering, sensing, and diagnosis. Gold is widely investigated nanomaterial for the last couple of decades, since it has unique surface properties and very low toxicity to biological environment. In this work, we present a novel synthesis of gold nanoparticles (GNPs) exhibiting both visible and near-IR absorbance without agglomeration. The surface of GNPs were analyzed by routine methods and the binding kinetics were investigated by Surface Plasmon Resonance (SPR) Spectroscopy. The unique optical properties of near-IR asorbing GNP colloids hold promise for biological applications.Article Citation - WoS: 10Citation - Scopus: 10Clinoptilolite-Rich Mineral as a Novel Carrier for the Active Constituents Present in Ginkgo Biloba Leaf Extract(Elsevier Ltd., 2008) Göktaş, Selda; Ülkü, Semra; Bayraktar, OğuzThe possible use of clinoptilolite-rich mineral as a novel carrier for the active constituents present in Ginkgo biloba leaf extract solutions was investigated. The flavonoid aglycone constituents were found to be selectively adsorbed on the clinoptilolite surface. The antioxidant activity determinations of the extract solutions were performed by the Trolox Equivalent Antioxidant Capacity (TEAC) assay. The antioxidant activity measurements performed for the Ginkgo leaf extract solutions showed decreasing antioxidant activities due to adsorption. The decrease in antioxidant activity was attributed to the adsorption of phenolic constituents on the clinoptilolite surface.