Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

Browse

Filters

2015 - 201912020 - 20231

Settings

Subject: search.filters.subject.Glycoalkaloids

Search Results

Now showing 1 - 2 of 2
  • Book Part
    Citation - Scopus: 3
    Tomato: Genetics, Genomics, and Breeding of Health-Related Traits
    (Springer Nature, 2023) Çelik,I.; Gürbüz Çolak,N.; Doğanlar,S.; Frary,A.
    Tomato (Solanum lycopersicum) is a popular crop due to its versatility and nutritional quality. In addition to its nutritional content, tomato is rich in various phytochemicals that are known to have beneficial effects on human health. These bioactive components include pigments like lycopene and Β-carotene, ascorbic acid (vitamin C), phenolic compounds, polyamines, and glycoalkaloids. Tomato metabolites have various bioactivities such as antihypertensive, antioxidant, anticancer, anti-inflammatory, antidiabetic, antiallergenic, antiatherogenic, antithrombotic, and antimicrobial effects. Research aimed at improving tomato for many of these specific activities is still in its infancy; however, a foundation of knowledge has been established for health-related (HR) traits in the crop. In this chapter, previous works surveying tomato germplasm for HR traits, conventional breeding, and genetic investigation of these characteristics are described. We also discuss research aimed at HR gene mapping and isolation as well as efforts to improve these traits via genetic engineering and genome editing. © Springer Nature Singapore Pte Ltd. 2023.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Glycoalkaloid Isolation From Solanum Linnaeanum Berries
    (EDP Sciences, 2015) Gürbüz, Nergiz; Karabey, Fatih; Öztürk, Taylan Kurtuluş; Kılınç, Ali; Frary, Anne; Doğanlar, Sami
    Glycoalkaloids are plant secondary metabolites that can be both harmful and beneficial to human health. They cause gastroenteric symptoms, coma and even death at high concentrations. It is thought that glycoalkaloids are toxic to human health as a result of their effects on the nervous system and destruction of cell membranes. On the other hand, glycoalkaloids can be effective drugs. For example, solasodine is used to treat skin cancer and tomatidine is used in cancer chemotherapy. Solasodine is also used as a precursor of steroidal drugs. The goal of the work was to isolate and separate efficiently these similar compounds. Materials and methods. Glycoalkaloids from Solanum linnaeanum berries were isolated using column chromatography and confirmed via NMR spectroscopy and MS/MS spectrometry. Results and discussion. The chemical structures of glycoalkaloids are nearly identical. For example, solamargine differs from solasonine in having a methyl group instead of a hydroxyl group bound to the sugar residue of the compound. Thus, their molecular weight and polarity are quite similar. In this work, the process yielded 37.1 mg solasonine, 92.3 mg solasonine and solamargine mix and 56.2 mg solamargine from 81.67 g dried S. linnaeanum berries. Conclusion. Solanum linnaeanum berries are a good source of these glycoalkaloids and the developed protocol proved efficient for purification of solasonine and solamargine.