Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Review Citation - Scopus: 2Wnt/β-catenin Signaling in Central Nervous System Regeneration(2025) Nazli, D.; Bora, U.; Ozhan, G.The Wnt/β-catenin signaling pathway plays a pivotal role in the development, maintenance, and repair of the central nervous system (CNS). This chapter explores the diverse functions of Wnt/β-catenin signaling, from its critical involvement in embryonic CNS development to its reparative and plasticity-inducing roles in response to CNS injury. We discuss how Wnt/β-catenin signaling influences various CNS cell types-astrocytes, microglia, neurons, and oligodendrocytes-each contributing to repair and plasticity after injury. The chapter also addresses the pathway's involvement in CNS disorders such as Alzheimer's and Parkinson's diseases, psychiatric disorders, and traumatic brain injury (TBI), highlighting potential Wnt-based therapeutic approaches. Lastly, zebrafish are presented as a promising model organism for studying CNS regeneration and neurodegenerative diseases, offering insights into future research and therapeutic development. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.Article Citation - WoS: 7Citation - Scopus: 7Bond-Based Peridynamic Fatigue Analysis of Ductile Materials With Neuber's Plasticity Correction(Springer, 2024) Altay, Ugur; Dorduncu, Mehmet; Kadioglu, Suat; Madenci, ErdoganThis study introduces an approach for performing bond-based (BB) peridynamic (PD) fatigue analysis of ductile materials. Existing BB PD fatigue models do not account for the effect of plastic deformation. The current approach addresses this by incorporating Neuber's plasticity correction concept into the fatigue model. Neuber's correction adjusts the stress and strain predictions of the PD elastic solution to account for local plastic deformation around crack tips. The PD fatigue simulations demonstrate the effectiveness of this method and improvements in fatigue life predictions by considering local plasticity effects. The numerical results first examine the response of a ductile plate without a crack under quasi-static monotonic loading. Subsequently, specimens exhibiting Mode I and mixed-mode crack propagation paths due to cyclic loading are analyzed. The PD predictions accurately capture the test data. Additionally, the model specifically investigates the effect of a stop hole on fatigue life.Conference Object Citation - WoS: 1Citation - Scopus: 2Three Dimensional Grain Boundary Modeling in Polycrystalline Plasticity(American Institute of Physics, 2018) Yalçınkaya, Tuncay; Özdemir, İzzet; Fırat, Ali OsmanAt grain scale, polycrystalline materials develop heterogeneous plastic deformation fields, localizations and stress concentrations due to variation of grain orientations, geometries and defects. Development of inter-granular stresses due to misorientation are crucial for a range of grain boundary (GB) related failure mechanisms, such as stress corrosion cracking (SCC) and fatigue cracking. Local crystal plasticity finite element modelling of polycrystalline metals at micron scale results in stress jumps at the grain boundaries. Moreover, the concepts such as the transmission of dislocations between grains and strength of the grain boundaries are not included in the modelling. The higher order strain gradient crystal plasticity modelling approaches offer the possibility of defining grain boundary conditions. However, these conditions are mostly not dependent on misorientation of grains and can define only extreme cases. For a proper definition of grain boundary behavior in plasticity, a model for grain boundary behavior should be incorporated into the plasticity framework. In this context, a particular grain boundary model ([l]) is incorporated into a strain gradient crystal plasticity framework ([2]). In a 3-D setting, both bulk and grain boundary models are implemented as user-defined elements in Abaqus. The strain gradient crystal plasticity model works in the bulk elements and considers displacements and plastic slips as degree of freedoms. Interface elements model the plastic slip behavior, yet they do not possess any kind of mechanical cohesive behavior. The physical aspects of grain boundaries and the performance of the model are addressed through numerical examples.