Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article A Machine Learning Framework for Advanced Analytical Detection of CD36 Using Immunosensors Below Limit of Detection(Elsevier Ltd, 2026) Yeke, M.C.; Gelen, S.S.; Fil, H.; Yalcin, M.M.; Gumus, A.; Yazgan, I.; Odaci, D.We introduce a machine learning (ML)-based regression framework for quantitative electrochemical analysis, representing a paradigm shift from traditional univariate methods to a multivariate approach. Conventional analysis is constrained by reducing the entire signal to a single peak current feature to define a linear range and calculate a limit of detection (LOD). In contrast, our methodology treats the Differential Pulse Voltammetry (DPV) curve as time-series data, creating a high-dimensional fingerprint by systematically evaluating multiple data windows with varying widths around the main signal peak to identify the most informative segment. To validate this approach, a biosensor was developed by immobilizing Anti-CD36 antibodies on polydopamine-modified screen-printed carbon electrodes for the detection of CD36, a key protein in metabolism and immunity. Measurements were collected across 12 concentrations, including blank samples, spanning a range of 0 to 25 ng/mL. Following data augmentation, nine different regression models were evaluated, with the top-performing models achieving near-perfect prediction accuracy (R2>0.99) across this entire range. This high accuracy across the full concentration spectrum quantitatively demonstrates the method's ability to operate without relying on traditional concepts like linear range or LOD, enabling reliable detection at ultra-low levels. Furthermore, the immunosensor exhibited high selectivity against common interferents and excellent recovery in human serum. This methodology represents a significant advancement in analytical electrochemistry, providing a transferable approach for enhancing sensitivity in biomarker detection with potential applications in clinical diagnostics and biomedical research. The codes and dataset are made publicly available on GitHub to support further research: https://github.com/miralab-ai/biosensors-AI. © 2026 The Author(s)Article Predicting the Area Moment of Inertia of Beam and Column Using Machine Learning and Hypernetexplorer(Springer Science and Business Media Deutschland GmbH, 2025) Aydın, Y.; Nigdeli, S.M.; Roozbahan, M.; Bekdaş, G.; Işıkdağ, Ü.Beams and columns are the most important elements of steel frame structures. Damage to the beam or column can lead the structure to serious hazards and cause collapse. In the structural engineering literature, it has been observed that there is not much work for area moment of inertia estimation of beam and column. The aim of this study was to predict the area moment of inertia of beam and column using HyperNetExplorer developed by the authors. This method aims to bring innovation by optimizing artificial neural networks (ANNs). In this study, a prediction study is performed using 306 collected data on beam and column area moment of inertia. Classical ML models (linear regression (LR), decision tree regression (DTR), K neighbors regression (KNN), polynomial regression (PR), random forest regression (RFR), gradient boosting regression (GBR), histogram gradient boosting regression (HGBR)) and NAS and HyperNetExplorer were applied to predict beam and column area moment of inertia. The prediction performances were compared using different performance metrics (coefficient of determination (R2) and mean squared error (MSE)) and HyperNetExplorer developed by the authors showed the highest performance (R2 = 0.98, MSE = 246.88). Furthermore, SHapley additive explanations (SHAP) were used to explain the effects of features in the prediction models and it was observed that the most effective features for model predictions were loading on beam and length. The results show that the proposed NAS base approach and the developed tool, HyperNetExplorer, provides better performance when compared with classical ML methods. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2025.Article Regression Analysis of Material Properties and Hardness of Dense Boron Carbide(Wiley, 2025) Toksoy, M. Fatih; Haber, Richard A.Material properties directly affect the final performance of the produced articles. This study aims to establish a correlation between materials properties and hardness of boron carbide samples. Ten different boron carbide powders were sintered to high densities by spark plasma sintering, and material properties (grain size, density, stoichiometry, and free carbon) were analyzed. Hardness tests were conducted on these samples. All experimental procedures were completed by a single operator, and the same instruments were used for all the samples. Multiple linear regressions using the ordinary least squares method in SPSS were carried out to identify the relationship between hardness and material properties. Analyses showed density is the most dominant property, surpassing any other parameter. Grain size became more dominant at higher densities (>99%) and affected hardness results. Both grain size and density are the result of the starting powder and the densification procedure. This study showed that 80% of the hardness variation can be explained by this model.Article Citation - WoS: 3Citation - Scopus: 3Regression-Based Prediction for Task-Based Program Performance(World Scientific Publishing, 2019) Öz, Işıl; Bhatti, Muhammad Khurram; Popov, Konstantin; Brorsson, MatsAs multicore systems evolve by increasing the number of parallel execution units, parallel programming models have been released to exploit parallelism in the applications. Task-based programming model uses task abstractions to specify parallel tasks and schedules tasks onto processors at runtime. In order to increase the efficiency and get the highest performance, it is required to identify which runtime configuration is needed and how processor cores must be shared among tasks. Exploring design space for all possible scheduling and runtime options, especially for large input data, becomes infeasible and requires statistical modeling. Regression-based modeling determines the effects of multiple factors on a response variable, and makes predictions based on statistical analysis. In this work, we propose a regression-based modeling approach to predict the task-based program performance for different scheduling parameters with variable data size. We execute a set of task-based programs by varying the runtime parameters, and conduct a systematic measurement for influencing factors on execution time. Our approach uses executions with different configurations for a set of input data, and derives different regression models to predict execution time for larger input data. Our results show that regression models provide accurate predictions for validation inputs with mean error rate as low as 6.3%, and 14% on average among four task-based programs.Book Part Citation - WoS: 299Citation - Scopus: 406Introduction To Machine Learning(Humana Press, 2014) Baştanlar, Yalın; Özuysal, MustafaThe machine learning field, which can be briefly defined as enabling computers make successful predictions using past experiences, has exhibited an impressive development recently with the help of the rapid increase in the storage capacity and processing power of computers. Together with many other disciplines, machine learning methods have been widely employed in bioinformatics. The difficulties and cost of biological analyses have led to the development of sophisticated machine learning approaches for this application area. In this chapter, we first review the fundamental concepts of machine learning such as feature assessment, unsupervised versus supervised learning and types of classification. Then, we point out the main issues of designing machine learning experiments and their performance evaluation. Finally, we introduce some supervised learning methods.Article Citation - WoS: 28Citation - Scopus: 18Artificial Neural Network Prediction of Tropospheric Ozone Concentrations in Istanbul, Turkey(John Wiley and Sons Inc., 2010) İnal, FikretTropospheric (ground-level) ozone has adverse effects on human health and environment. In this study, next day's maximum 1-h average ozone concentrations in Istanbul were predicted using multi-layer perceptron (MLP) type artificial neural networks (ANNs). Nine meteorological parameters and nine air pollutant concentrations were utilized as inputs. The total 578 datasets were divided into three groups: training, cross-validation, and testing. When all the 18 inputs were used, the best performance was obtained with a network containing one hidden layer with 24 neurons. The transfer function was hyperbolic tangent. The correlation coefficient (R), mean absolute error (MAE), root mean squared error (RMSE), and index of agreement or Willmott's Index (d2) for the testing data were 0.90, 8.78 μg/m3, 11.15μg/m3, and 0.95, respectively. Sensitivity analysis has indicated that the persistence information (current day's maximum and average ozone concentrations), NO concentration, average temperature, PM10, maximum temperature, sunshine time, wind direction, and solar radiation were the most important input parameters. The values of R, MAE, RMSE, and d2 did not change considerably for the MLP model using only these nine inputs. The performances of the MLP models were compared with those of regression models (i.e., multiple linear regression and multiple non-linear regression). It has been found that there was no significant difference between the ANN and regression modeling techniques for the forecasting of ozone concentrations in Istanbul. Tropospheric ozone has adverse effects on human health and environment. Here, the next-day's maximum 1-h average ozone concentrations in Istanbul were predicted using multi-layer perceptron type artificial neural networks (MLP-ANNs). The MLP-ANNs were compared to multiple linear and multiple non-linear regression models. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.