Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Ten Questions Concerning Circularity in the Built Environment(Pergamon-Elsevier Science Ltd, 2026) Kayacetin, N. Cihan; Aslanoglu, Rengin; Piccardo, Chiara; Afacan, Yasemin; Masera, Gabriele; Li, Qiuxian; Van Hoof, JoostThe rapid urbanisation of our societies calls for an urban renewal movement, including developing new areas to accommodate housing facilities and services and regenerating existing urban areas. Yet, urban renewal projects pose trade-offs impacting both environmental and socio-economic aspects. The renovation and new construction of buildings can escalate the use of energy and material resources as well as increasing greenhouse gas emissions. The European Union plays a leading role in promoting the transition towards sustainable and inclusive cities, whereas other regions such as North America, Australia and Asia follow suit via Circular Economy Action Plans or Frameworks, highlighting the need to enhance resource efficiency in buildings through the use of durable and circular materials. Current research on resource efficiency in buildings follows the Circular Economy concept, which aims to reduce the use of raw materials and the waste of existing materials while retaining their value for as long as possible. However, the role of the circular economy in sustainable transition and the adoption of its principles in urban contexts remain unclear while its practical implementation still faces significant challenges, including the lack of analytical instruments and assessment methods as well as co-creative approaches. This 'Ten Questions contribution' provides an overview of the pressing issues concerning circularity in the built environment, the state-of-the-art and best practices, challenges and benefits, policies and regulations, as well as numerous strategies applied on the building and neighbourhood level, assessment methodologies and future trends.Article Citation - WoS: 28Citation - Scopus: 31Lysosomal Cathepsin a Plays a Significant Role in the Processing of Endogenous Bioactive Peptides(Frontiers Media S.A., 2016) Timur, Zehra Kevser; Akyıldız Demir, Seçil; Seyrantepe, VolkanLysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA present in the lysosomal multienzyme complex to facilitate the correct lysosomal routing, stability and activation of with beta-galactosidase and alpha-neuraminidase. Beside CTSA has role in inactivation of bioactive peptides including bradykinin, substances P, oxytocin, angiotensin I and endothelin-I by cleavage of 1 or 2 amino acid(s) from C-terminal ends. In this study, we aimed to elucidate the regulatory role of CTSA on bioactive peptides in knock-in mice model of CTSA(S190A). We investigated the level of bradykinin, substances P, oxytocin, angiotensin I and endothelin-I in the kidney, liver, lung, brain and serum from CTSA(S190A) mouse model at 3- and 6-months of age. Our results suggest CTSA selectively contributes to processing of bioactive peptides in different tissues from CTSA(S190A) mice compared to age matched WT mice.