Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

Browse

Filters

2020 - 20212

Settings

Access Right: Closed AccessAuthor: search.filters.author.Yılmaz, Selahattin

Search Results

Now showing 1 - 2 of 2
  • Article
    Citation - WoS: 34
    Citation - Scopus: 39
    Aptamer-Based Electrochemical Biosensing Strategy Toward Human Non-Small Cell Lung Cancer Using Polyacrylonitrile/Polypyrrole Nanofibers
    (Springer, 2020) Kıvrak, Ezgi; İnce Yardımcı, Atike; İlhan, Recep; Ballar Kırmızıbayrak, Petek; Yılmaz, Selahattin; Kara, Pınar
    In the present study, a sensitive electrochemical aptamer-based biosensing strategy for human non-small cell lung cancer (NSCLC) detection was proposed using nanofiber-modified disposable pencil graphite electrodes (PGEs). The composite nanofiber was comprised of polyacrylonitrile (PAN) and polypyrrole (PPy) polymers, and fabrication of the nanofibers was accomplished using electrospinning process onto PGEs. Development of the nanofibers was confirmed using scanning electron microscopy (SEM). The high-affinity 5 '-aminohexyl-linked aptamer was immobilized onto a PAN/PPy composite nanofiber-modified sensor surface via covalent bonding strategy. After incubation with NSCLC living cells (A549 cell line) at 37.5 degrees C, the recognition between aptamer and target cells was monitored by electrochemical impedance spectroscopy (EIS). The selectivity of the aptasensor was evaluated using nonspecific human cervical cancer cells (HeLa) and a nonspecific aptamer sequence. The proposed electrochemical aptasensor showed high sensitivity toward A549 cells with a detection limit of 1.2 x 10(3)cells/mL. The results indicate that our label-free electrochemical aptasensor has great potential in the design of aptasensors for the diagnostics of other types of cancer cells with broad detection capability in clinical analysis.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    Synthesis of Butyl Glucoside Over Sulphated Zr-Sba and Tungstophosphoric Acid Incorporated Sba-15 Catalysts
    (Elsevier Ltd., 2021) Mutlu, Nahide Nuran; Yılmaz, Selahattin
    Glycosidation of glucose with n-butanol was studied over sulphated Zr incorporated SBA-15 and tungstophosphoric acid (TPA) incorporated SBA-15 catalysts. The catalysts were prepared with different Zr, TPA and SO4 amounts via hydrothermal synthesis. SBA-15 structure was preserved and Zr and TPA were successfully incorporated. Sulphation improved the acidity of Zr-SBA-15 and the ratio of Brønsted to Lewis acid sites (B/L) increased. Thus, much higher butyl glucoside yields (about 70 %) were obtained over SO4/Zr-SBA-15 catalysts. However, 15 % activity loss was observed after 2 re-use due to sulphate leaching. TPA-SBA-15 catalysts had the highest B/L and provided very high catalytic activity with butyl glucoside yields above 95 %. The initial rate of butyl glucoside formation over TPA-SBA-15 catalysts were close to that of H2SO4. These catalysts were found stable and reusable. Reaction temperature and catalysts amount was studied as the reaction parameters over the most active and selective catalyst. © 2020 Elsevier B.V.