Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Development and Evaluation of 177Lu-Imatinib: Radiolabeling and Cell Culture Studies(Walter de Gruyter GmbH, 2025) Ozgenc, E.; Karpuz, M.; Guler, G.; Burak, Z.; Başpainar, Y.; Gundogdu, E.A.Targeted radiopharmaceuticals offer promising approaches for cancer diagnosis and therapy. This study developed freeze-dried kit formulations of 177Lu-Imatinib (IMT) and evaluated their potential efficacy through in vitro studies. Four formulations (F1-F4) containing IMT and chelating agents were prepared and characterized via Fourier transform infrared (FTIR), ultraviolet spectrum (UV), and thermogravimetric analysis (TGA) to confirm complex formation. Biocompatibility was assessed in NIH-3T3 cells using the MTT assay. Radiolabeling with 177Lu was optimized by varying pH, incubation time, and reactant ratios. Radiochemical purity and stability were analyzed over 7 days using HPLC. Binding affinity and cytotoxicity were evaluated in MCF-7 and NIH-3T3 cells. Spectroscopic analyses confirm successful complex formation. All formulations exhibited >90% viability in NIH-3T3 cells. Optimal radiolabeling conditions (45mg IMT-chelator, pH 5, 60min incubation) yielded >90% efficiency, with stable radiolabeling for 7 days. The 177Lu-IMT-DOTA (F3) formulation showed significantly higher binding and cytotoxic effects in MCF-7 cells compared to controls. The 177Lu-IMT-DOTA (F3) kit demonstrates high radiolabeling efficiency, stability, and selective in vitro cytotoxicity toward breast cancer cells, supporting its potential as a targeted radiopharmaceutical. © 2025 Walter de Gruyter GmbH, Berlin/Boston 2025.Article Citation - WoS: 1Citation - Scopus: 1Assessment of the Validity and Reliability of Edinburgh Postpartum Depression Scale in Turkish Men(Walter de Gruyter GmbH, 2024) Alkan, C.; Didikoǧlu, A.; Çöme, O.; Yllmaz, B.; Mevsim, V.Objectives: Perinatal depression (PD) affects individuals during pregnancy and early parenthood, resembling major depression. Recent research highlights paternal perinatal depression (PPD) in fathers. PPD has adverse effects on fathers and their children. This study assesses the Turkish version of the Edinburgh Postnatal Depression Scale (EPDS) for Turkish fathers, aiming to provide a tool for PPD identification. Methods: This methodological study validates the EPDS for Turkish fathers and explores associations with demographic and psychosocial factors. The study involved 295 fathers with infants aged 2 weeks to 12 months. The EPDS, originally designed for perinatal depression and validated in Turkish women, was used. Fathers completed a participant information questionnaire, the EPDS, and the Beck Depression Inventory (BDI) during clinic visits. Data on sociodemographic factors, paternal roles, and pregnancy and postpartum support were collected. Mothers also completed the EPDS. Descriptive statistics, exploratory factor analysis, confirmatory factor analysis, and correlation tests were used. Results: The study included fathers with an average age of 30.5 years, mostly with a high school education or higher. The EPDS had a mean total score of 3.1. Factor analysis suggested a three-factor structure for the EPDS in Turkish fathers, including anhedonia, anxiety, and depression. Confirmatory factor analysis validated the three-factor structure, with acceptable model fit indices. Positive correlations were found between fathers' EPDS scores, maternal EPDS scores, and paternal BDI scores. The EPDS effectively discriminated between different levels of depression severity. Various factors, such as education level and lack of support during pregnancy and after childbirth, were associated with higher EPDS scores. Conclusions: These findings emphasize the significance of assessing and addressing PPD in fathers, supporting the use of the EPDS as a valid tool in the Turkish context. The three-factor structure aligns with international research, highlighting the importance of a multi-dimensional approach to PPD assessment. Early intervention can mitigate PPD's impact on fathers, mothers, and children, benefiting mental health and well-being. © 2024 Walter de Gruyter GmbH, Berlin/Boston.Book Part Citation - Scopus: 1A Recycling Route of Plastics Via Electrospinning: From Daily Wastes To Functional Fibers(Walter de Gruyter GmbH, 2019) Isık, Tuğba; Horzum,N.; Demir, Mustafa MuammerSince large-scale plastic production has begun in the 1940s, plastics have been produced and used globally, bringing many advantages to modern life. The consumption of plastics has increased exponentially due to their low cost, chemical resistance, lightness, durability and ability to combine with other materials. However, plastic materials represent high tonnage in urban wastes, and it is known that these plastics discarded at the end of their useful life by filling the landfill sites. Electrospinning is a well-established and versatile technique for the fabrication of submicron fibers. In addition, it is a promising approach for the recycling of waste polymers without using complex methodologies. In this chapter, utilization of electrospinning approach for the recycling of daily wastes will be discussed. The literature about the daily wastes of both synthetic materials and natural/agricultural materials will be analyzed, and the applications of these materials will be given in detail. © 2019 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.Article Citation - WoS: 5Citation - Scopus: 4Influence of Partitioning Treatment on Microstructure and Mechanical Properties of an Alloyed Ductile Iron Austempered at Different Temperatures(Walter de Gruyter GmbH, 2023) Neite, Maximilian; Münstermann, Sebastian; Nalçacı, Burak; Davut, Kemal; Erdoğan, MehmetThe present study was conducted to uncover effects of partitioning treatment on Cu-Ni-Mo alloyed ductile iron (DI) austempered at different temperatures. For this purpose, the DI samples, produced via sand casting, were austenitized at 900 °C for 60 min, followed by austempering at the temperatures of 275-325-375 °C for 120 min and afterwards a partitioning treatment was applied at 200 °C for 15 min. In the characterization studies, dilatometer, image analysis, JMat-Pro, mechanical tests, XRD, optical microscope, and scanning electron microscope (SEM) equipped with EBSD detector were utilized. Characterization studies showed that the effects of partitioning treatment were directly correlated with austempering temperature and high carbon austenite volume fraction changed in the range of 19.48-35.45%. That redistribution of carbon (C) between bainitic ferrite and high carbon austenite occurred, in turn, the carbon content of high carbon austenite increased with the partitioning treatment irrespective of austempering temperature were uncovered. Furthermore, the partitioning treatment considerably changed the grain morphologies of both high carbon austenite and banitic ferrite. As a consequence of these microstructural differences, the highest tensile strength of 1489.2 MPa was established in the sample austempered at 275 °C and partitioned at 200 °C, whereas the highest ductility of 5.61% acquired at the austempering temperature of 375 °C. © 2023 Walter de Gruyter GmbH, Berlin/Boston.Article Citation - WoS: 3Citation - Scopus: 3Nondestructive Microstructural Characterization of Austempered Ductile Iron(Walter de Gruyter GmbH, 2023) Tüzün, Mert Yağız; Yalçın, Mustafa Alp; Davut, Kemal; Kılıçlı, VolkanAustempered ductile iron (ADI) has been preferred in a wide range of applications due its unique combination of high strength, good ductility, wear resistance and fracture toughness together with lower cost and lower density compared to steels. Magnetic Barkhausen noise (MBN) measurement offers a better alternative to traditional characterization techniques by being fast and non-destructive. A simple linear regression using only one single independent variable cannot correlate the MBN with the microstructure of ADI, since its microstructure is multi component. Multiple linear regression analysis (MLRA) was used to build a model that uses the characteristic features of microstructural constituents as input parameters to predict the MBN. For that purpose, Cu-Ni-Mo alloyed ductile iron samples austempered between 325 and 400 degrees C and for 45-180 min duration were used. The results show that MBN is most sensitive to the size and shape of acicular ferrite and retained austenite. Moreover, MBN is almost insensitive to the size, morphology and volume fraction of graphite particles. This indicates that retained austenite pins the domain walls more effectively than the graphite particles. Considering the results MLRA, MBN technique can be used to characterize the ausferritic microstructure of ADI.Article Citation - WoS: 4Citation - Scopus: 5Effects of Tib2 Nanoparticle Content on the Microstructure and Mechanical Properties of Aluminum Matrix Nanocomposites(Walter de Gruyter GmbH, 2017) Kandemir, SinanThe present work reports the fabrication of A357 alloy matrix nanocomposites reinforced with 0.5, 1.0 and 2.0 wt.-% TiB2 nanoparticles (20-30 nm) by a novel method which is the combination of semi-solid mechanical mixing and ultrasonic dispersion of nanoparticles in liquid state. The microstructural and mechanical properties of the fabricated nanocomposites were investigated. The microstructural studies conducted with optical and advanced electron microscopes indicated that reasonably effective deagglomeration and uniform distribution of TiB2 nanoparticles into the matrix were achieved. Transmission electron microscopy studies also confirmed that the nanoparticles were embedded into the matrix and a good bonding was obtained between the matrix and the reinforcement. Increasing nanoparticle content led to grain refinement and significant enhancement in the mechanical properties of nanocomposites. The addition of 0.5, 1.0, and 2.0 wt.-% TiB2 nanoparticles increased the 0.2 % proof stress of matrix alloy by approximately 31, 48 and 61 %, respectively. The contribution of different mechanisms to the strength enhancement is discussed. It is proposed that the strengthening is mainly due to Orowan mechanism and dislocation generation effect by the coefficient of thermal expansion mismatch between the TiB2 nanoparticles and the matrix.Article Citation - WoS: 1Citation - Scopus: 2Off-Design Analysis of Transonic Bypass Fan Systems Using Streamline Curvature Through-Flow Method(Walter de Gruyter GmbH, 2019) Acarer, Sercan; Özkol, ÜnverThe two-dimensional streamline curvature through-flow modeling of turbomachinery is still a key element for turbomachinery preliminary analysis. Basically, axisymmetric swirling flow field is solved numerically. The effects of blades are imposed as sources of swirl, work input/output and entropy generation. Although the topic is studied vastly in the literature for compressors and turbines, combined modeling of the transonic fan and the downstream splitter of turbofan engine configuration, to the authors' best knowledge, is limited. In a prior study, the authors presented a new method for bypass fan modeling for inverse design calculations. Moreover, new set of practical empirical correlations are calibrated and validated. This paper is an extension of this study to rapid off-design analysis of transonic by-pass fan systems. The methodology is validated by two test cases: NASA 2-stage fan and GE-NASA bypass fan case. The proposed methodology is a simple extension for streamline curvature method and can be applied to existing compressor methodologies with minimum numerical effort.