Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Conference Object Citation - Scopus: 2Controlled Release of Doxorubicin From Electrospun Gelatin Nanofibers(Avestia Publishing, 2016) Mete,D.; Horzum,N.; Mohamed,G.Ş.Electrospinning has been recognized as an effective and inexpensive technique for fabrication of long fibers from various materials including polymers, composites and biomacromolecules with diameters ranging from a few nanometers to few micrometers [1]. The electrospun fibers form a unique structure which have a very large surface area-to-volume ratio and high porosity with very small pore size. Therefore, electrospun fibers could be a very promising material for many biomedical applications such as drug delivery, wound dressing, artificial organ and medical prosthesis [2, 3]. Polymer-based drug delivery systems are used to improve the therapeutic properties of drugs in a safer, effective and reliable manner [4]. The variety of biodegradable polymers can be electrospinnable [5]. At present, researches on biodegradable nanofibers focus on development for delivering drugs and releasing them continuously over a period of time. Drug delivery with polymeric nanofibers with higher drug encapsulation efficiency and better stability than other drug formulations possess high surface-to-volume ratio which would accelerate the solubility of drug in the aqueous solution and enhance the efficiency of the drug [6, 7]. Gelatin is a natural biopolymer derived from animal collagen, having a long history of safe use in pharmaceuticals, cosmetics as well as food products [8]. Because of its great biocompatibility and biodegradability properties, gelatin has a broad applications in biomedical fields, especially as a drug delivery carrier [9]. In the current work electrospun fibers were developed as a new system for the delivery and release of an anticancer agent doxorubicin via electrospinning technique. The morphology of the fibers was analyzed by scanning electron microscopy(SEM), fourier transform infrared spectroscopy (FTIR). The fibers were made from gelatin as a biodegradable polymer and the release of doxorubicin was followed by UV-vis spectroscopy in phosphate buffer of pH 7.4 at 25 °C and 37 °C. The release profiles from gelatin electrospun fiber mats were compared with casting films with the same composition. © 2016, Avestia Publishing. All rights reserved.Conference Object Citation - Scopus: 2Experimental Study of the Evolution of the Breach and the Discharge Through the Breach Resulting From Piping Due To Seepage at the Earth-Fill Dam Bottom(Avestia Publishing, 2022) Güney, Mehmet Şükrü; Dumlu, Emre; Okan, Merve; Bor, Aslı; Aklık, Pelin; Tayfur, GökmenPiping is one of the main causes of the earth-fill dam failures. Most of the researchers realizing numerical analyses make some simplified assumptions concerning the shape of the breach and the discharge of water flowing through the breach. The aim of this study is to realize experiments to provide data needed to perform numerical analyses by making more realistic assumptions. The dam having a height of 0.6 m, a bottom width of 2 m and a crest width of 0.20 m is built in a channel 1 m wide, 0.81 m high and 6.14 m long. The evolution of the breach and the discharge through the breach resulting from piping due to seepage at the earth-fill dam bottom was investigated experimentally. The evolution of the dam failure is recorded by six cameras located at different locations. The time-varied of the breach areas at upstream and downstream sides are determined by applying the Gauss Area functions. The discharge of water through the breach and average outflow velocity are determined by using the continuity equation.Conference Object Effect of Electric Field on Interfacial Thermal Resistance Between Silicon and Water at Nanoscales(Avestia Publishing, 2019) Yenigün, Onur; Barışık, MuratIn this study, heat transfer rate of a nano-confined liquid is controlled by applying an electric field parallel to the heat transfer direction. Molecular Dynamics simulations are performed for deionized water confined between silicon slabs, where their surfaces oppositely charged to create an electric field perpendicular to the silicon wall to promote the electrowetting. Electric field strengths used in this study are 0, 0.18 and 0.35 V/nm. To investigate the effect of electric field on heat transfer, first water density profiles near the silicon walls are examined. Results shows that by applying electric field, water molecules near the silicon walls develop layering, which indicates the increased solid/liquid coupling. With the increasing electric field strength, an increase in the peak of the density layering is observed. Furthermore, heat transfer at the solid/liquid interface is characterized with the Kapitza length values. The results show that applying electric field reduces the interfacial thermal resistance between water and silicon due to the increased solid/liquid coupling and doubles the total heat flux. © 2019, Avestia Publishing.Conference Object Molecular Dynamics Study of the Thermal Conductivity of Graphene Coated Copper(Avestia Publishing, 2019) Toprak, Kasım; Ersavaş, GizemIn this study, the thermal conductivity of various size of pure copper, pure graphene and, different number of layer graphene coated copper models are studied using non-equilibrium molecular dynamics (NEMD) simulations. Our findings show that the thermal conductivity of graphene coated copper is higher than the uncoated ones. Furthermore, results also indicate that single layer graphene (SLG) model has the highest thermal conductivity as compared to the other model. Even though multiple layer graphene (MLG) has lower thermal conductivity value compare to SLG, this study shows that the thermal conductivity of MLG coated copper has higher thermal conductivity than SLG coated one. The most important finding in this study suggests that the thermal conductivity of copper can be improved using high thermal conductivity materials like graphene. © 2019, Avestia Publishing.