Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Reduced Phase Space Quantization and Quantum Corrected Entropy of Schwarzschild-De Sitter Horizons
    (Elsevier B.V., 2026) Jalalzadeh, S.; Moradpour, H.
    This paper investigates the quantization of the Schwarzschild–de Sitter (SdS) black hole (BH) using the Misner–Sharp–Hernandez (MSH) mass as the internal energy in a reduced phase space framework. After introducing the canonical variables of the reduced phase space, we derive a discrete spectrum for the surface areas of the BH event horizon (EH) as well as MSH masses. We utilized the MSH mass spectrum to obtain the entropy of the BH. The entropy of the BH and cosmic EHs reveals a logarithmic correction to the Bekenstein–Hawking term. Our results support the robustness of the logarithmic form of quantum corrections in SdS thermodynamics. © 2026 The Authors.
  • Article
    Ten Questions Concerning Circularity in the Built Environment
    (Pergamon-Elsevier Science Ltd, 2026) Kayacetin, N. Cihan; Aslanoglu, Rengin; Piccardo, Chiara; Afacan, Yasemin; Masera, Gabriele; Li, Qiuxian; Van Hoof, Joost
    The rapid urbanisation of our societies calls for an urban renewal movement, including developing new areas to accommodate housing facilities and services and regenerating existing urban areas. Yet, urban renewal projects pose trade-offs impacting both environmental and socio-economic aspects. The renovation and new construction of buildings can escalate the use of energy and material resources as well as increasing greenhouse gas emissions. The European Union plays a leading role in promoting the transition towards sustainable and inclusive cities, whereas other regions such as North America, Australia and Asia follow suit via Circular Economy Action Plans or Frameworks, highlighting the need to enhance resource efficiency in buildings through the use of durable and circular materials. Current research on resource efficiency in buildings follows the Circular Economy concept, which aims to reduce the use of raw materials and the waste of existing materials while retaining their value for as long as possible. However, the role of the circular economy in sustainable transition and the adoption of its principles in urban contexts remain unclear while its practical implementation still faces significant challenges, including the lack of analytical instruments and assessment methods as well as co-creative approaches. This 'Ten Questions contribution' provides an overview of the pressing issues concerning circularity in the built environment, the state-of-the-art and best practices, challenges and benefits, policies and regulations, as well as numerous strategies applied on the building and neighbourhood level, assessment methodologies and future trends.
  • Article
    AI-Supported Seismic Performance Evaluation of Structures: Challenges, Gaps, and Future Directions at Early Design Stages
    (Elsevier Sci Ltd, 2026) Ak, Fatma; Ekici, Berk; Demir, Ugur
    This study reviews 91 journal articles that intersect with earthquake-resistant building design and artificial intelligence (AI)- based modeling, utilizing machine learning, deep learning, and metaheuristic optimization algorithms. Previous reviews on AI applications have examined engineering problems without considering the impact of architectural design parameters and structural irregularities on seismic performance. This review discusses the role of AI in integrating architectural design variables and seismic performance objectives, highlighting challenges, gaps, and future directions in the early design phase. The reviewed articles demonstrate that AI is successful in addressing seismic performance objectives; however, a holistic framework for assessing architectural and structural variables has not been presented. The review highlights key findings, gaps, and future directions for those involved in earthquake-resistant building design utilizing AI.
  • Article
    Hydrogeochemical Assessment and Health Risks of Groundwater in Sahand Volcanic Foreland (NW Iran): Arsenic Speciation and Heavy Metal Risk Indicators
    (Academic Press Inc Elsevier Science, 2026) Ghayurdoost, Farhad; Zarghami, Mahdi; Sadeghfam, Sina; Jabraili-Andaryan, Nasser; Nikmaram, Sara; Baba, Alper; Mosaferi, Mohammad
    Due to the toxic nature of arsenic (As) and its elevated concentrations in many water resources, numerous studies have focused on understanding its origin, distribution, and impacts. This study aimed to identify the dominant As species in groundwater of the Sahand Volcanic Foothills, assess water quality indices, and examine heavy metal (HM) concentrations to address rising concerns about groundwater contamination. A total of 21 groundwater samples were collected and analyzed in accordance with world health organization (WHO) guidelines. Although most samples fell within acceptable ranges, several (notably S10, S20, and S21) exhibited elevated levels of total dissolved solids (TDS), electrical conductivity (EC), and HMs, particularly iron (Fe) and As. Hydrochemical assessments using Piper, Gibbs, Stiff, and Schoeller diagrams indicated that geochemical processes resulting from rock dissolution were the main factors controlling groundwater chemistry, with limited influence from anthropogenic pollution. According to the groundwater quality index (GWQI), most samples were categorized as "good" to "excellent," though some areas ranged from "moderate" to "very poor." HM pollution indices revealed that As concentrations exceeded permissible limits. Health risk assessments further showed that both oral and dermal exposure posed significant carcinogenic and non-carcinogenic risks, especially for children. Speciation analysis indicated that arsenate (As V) was the dominant form of As, consistent with oxidizing aquifer conditions, and is less biologically hazardous than arsenite (As III). The study highlights the necessity of continuous groundwater monitoring, effective pollution source management, and implementation of protective regulations to mitigate environmental and health risks in the region.
  • Article
    Notum1a Inhibition Promotes Neurogenesis in the Adult Zebrafish Brain
    (Nature Portfolio, 2025) Kocagoz, Yigit; Erdogan, Nuray Sogunmez; Ozdinc, Sevval; Ipekgil, Dogac; Katkat, Esra; Ozhan, Gunes
    Notum is a carboxylesterase enzyme that modulates extracellular signaling by hydrolyzing palmitoleoyl residues from proteins, thereby influencing key pathways involved in cell differentiation, survival, and proliferation. While notum1 expression has been identified in the brain, its role in adult neurogenesis remains poorly understood. Using the adult zebrafish brain as a model system, we demonstrate that the notum1a homolog is broadly expressed across various brain cell types but is absent in undifferentiated radial glial cells. Pharmacological inhibition of Notum activity with the small molecule inhibitor ABC99 stimulates activation of radial glial cells, leading to increased neurogenesis. A BrdU pulse-chase assay confirms that ABC99-induced proliferation enhances the production of mature neurons. Despite Notum's established role in Wnt signaling, transcriptional analysis following ABC99 treatment reveals no sustained impact on Wnt pathway targets, suggesting that Notum may regulate neurogenesis through alternative mechanisms. Our findings highlight notum1a as a potential modulator of neural progenitor cell dynamics in the adult brain and suggest that targeting Notum could represent a novel therapeutic strategy for neurodegenerative conditions characterized by impaired neurogenesis.
  • Article
    Temporal Coherence of Single Photons Emitted by Hexagonal Boron Nitride Defects at Room Temperature
    (Amer Chemical Soc, 2026) Martinez-Pons, Juan Vidal; Kim, Sang Kyu; Behrens, Max; Izquierdo-Molina, Alejandro; Menendez Rua, Adolfo; Pacal, Serkan; Anton-Solanas, Carlos
    Color centers in hexagonal boron nitride (hBN) emerge as promising quantum light sources at room temperature, with potential applications in quantum communications, among others. The temporal coherence of emitted photons (i.e., their capacity to interfere and distribute photonic entanglement) is essential for many of these applications. Hence, it is crucial to study and determine the temporal coherence of this emission under different experimental conditions. In this work, we report the coherence time of the single photons emitted by an hBN defect in a nanocrystal at room temperature, measured via Michelson interferometry. The visibility of this interference vanishes when the temporal delay between the interferometer arms is a few hundred femtoseconds, highlighting that the phonon dephasing processes are 4 orders of magnitude faster than the spontaneous decay time of the emitter. We also analyze the single photon characteristics of the emission via correlation measurements, defect blinking dynamics, and its Debye-Waller factor. Our room temperature results highlight the presence of a strong electron-phonon coupling, suggesting the need to work at cryogenic temperatures to enable quantum photonic applications based on photon interference.
  • Article
    The Effects of Lactobacillus and/or Bifidobacterium in Fermented Foods on Cognitive Health: A Systematic Review
    (Frontiers Media SA, 2025) Harsa, Hayriye Sebnem; Gonzalez Domenech, Carmen Maria; Prvulovic, Milica; Agirbasli, Zeynep; Bagherzadehsurbagh, Erfan; Simeunovic, Valentina; Pracer, Smilja
    Background: Psychobiotics are microorganisms that modulate brain function via the gut-brain axis and are increasingly studied for their cognitive benefits. Lactobacillus and Bifidobacterium species, widely present in fermented foods, are considered safe and may influence cognition by modulating neuroinflammation, neurotransmitters, and gut barrier integrity. This systematic review examined the effects of foods fermented with these species on cognitive performance in healthy adults and individuals with mild cognitive impairment. Methods: We conducted the systematic review following EFSA guidelines, Cochrane methodology, and a PROSPERO protocol, using CADIMA for study selection and data extraction. PubMed, Scopus, and Cochrane Library were searched (1 January 1970-31 August 2023) for human intervention and observational studies assessing cognitive outcomes after ingestion of foods fermented with Lactobacillus or Bifidobacterium. Eligible populations included healthy adults and individuals with mild cognitive impairment; studies involving disease were excluded. Screening, data extraction, and bias assessment followed Muka et al.'s 24-step guide using ROBINS and Cochrane/CADIMA frameworks. Evidence was synthesized narratively, while a non-systematic component examined food characteristics, potential mechanisms, and factors affecting bioavailability of bioactive constituents. Results: We included 21 studies (8 interventional, 13 observational). The majority of studies reported benefits, particularly in episodic memory, executive functions, and global cognition, but evidence was limited by inadequate controls, small sample sizes, short interventions, inconsistent domain assessment, and incomplete food characterization. Observational studies had larger populations and longer follow-ups but were limited by exposure assessment and depth of cognitive testing. Conclusion: Consumption of foods fermented with Lactobacillus and/or Bifidobacterium species may offer promising cognitive benefits. However, following EFSA's guidance on the substantiation of health claims, the current evidence is "neither convincing nor sufficient" to establish a causal relationship. Well-designed studies with thorough product characterization are needed to substantiate effects and support potential health claims.
  • Article
    On the Strengths and Weaknesses of Virtual Reality in Distance Estimation in AEC Domain: A Meta-Analysis of Literature 2014–2024
    (Springer Science and Business Media Deutschland GmbH, 2026) Kurpınar, G.; Doǧan, F.; Çevik, A.; Kasali, A.
    Virtual reality (VR) became the most used extended reality system in architecture, engineering, and construction domains. It offers advantages through its immersive and interactive interface. There is, however, a need to investigate both its strengths and weaknesses especially in relation to the claim that it is a close surrogate for real-world performances. This study reports the findings of a meta-analysis on distance estimation (DE) in VR. Distance estimation, essential for spatial perception, remains to be a problem in VR even with advanced head-mounted displays. The study questions whether VR can match the real-world performance in DE to highlight its shortcomings as well as its potentials. The meta-analysis includes 77 pieces of data from 29 studies and investigates whether DE accuracy has improved and how DE interacts with task type, task environment, and target range. The results indicate VR is still underperforming in DE, head-mounted display’s weight is the significant factor, and task type and task environment significantly interact with DE. We conclude VR needs to be specifically tailored regarding the needs of practitioners in architecture and engineering industry and that it is not yet a substitute for real-world performances. © The Author(s) 2025.
  • Article
    3D-Printed Soy Protein and Microalga Films: A Sustainable Approach with Antioxidant Functionality
    (Elsevier, 2026) Barekat, Sorour; Dogan, Buse; Uzuner, Sibel; Ubeyitogullari, Ali
    This study investigated the optimization and fabrication of soy protein isolate (SPI)-green microalga (MA) 3D-printed films. For optimizing 3D printing, the effects of MA concentration, nozzle size (0.52-0.81 mm), and speed (10-20 mm/s) were examined. The printed films were then dried, and color, mechanical properties, water vapor permeability, structure, and antioxidant activity were analyzed. All the formulations showed shear-thinning behavior and rapid recovery. The concentration of 3 % MA, nozzle size of 0.72 mm, and printing speed of 20 mm/s were selected as the optimized conditions for the best 3D printability. Compared with the control, their elongation at break decreased by more than 16 %, while puncture strength increased by over 12 %, and tensile strength rose by more than 40 %. Water vapor permeability decreased by more than 40 % with the addition of MA. The microstructure images and secondary structure confirmed the formation of a less porous and stronger gel network with an increase in MA concentration from 0 to 5 % (w/w). The antioxidant properties of SPI films also increased two-fold with the addition of MA. These findings highlight that the 3D-printed edible films with antioxidant properties could be used as an eco-friendly and nutritious alternative to petroleum-based films in food packaging.
  • Article
    Comparative Stability of Synthetic and Natural Polymeric Micelles in Physiological Environments: Implications for Drug Delivery
    (MDPI, 2025) Polat, Hurriyet; Eren, Merve Cevik; Polat, Mehmet; Koss, Kyle M.; Polat, Onur K.
    Polymeric micelles are widely studied as nanocarriers for hydrophobic drugs, yet their structural stability under physiological conditions remains a major limitation. This review provides a comparative evaluation of synthetic and natural polymeric micelles with a focus on their stability under dilution and in protein-rich environments. The discussion integrates thermodynamic and kinetic factors governing micelle integrity and examines how molecular composition, hydrophobic segment length, and core-shell modifications influence disintegration behavior. While synthetic micelles commonly collapse below their critical micelle concentration during intravenous administration, natural polymeric micelles, such as those derived from chitosan, alginate, or heparin, exhibit improved resistance to dilution but remain vulnerable to protein-induced destabilization. Strategies such as core or shell cross-linking, surface functionalization, and natural polymer coatings are reviewed as promising approaches to enhance circulation stability and controlled drug release. The work provides a framework for designing micellar systems with balanced biocompatibility, biodegradability, and robustness suitable for clinical drug-delivery applications.