Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Seismic Risk Prioritization of Stone Masonry Building Stock in Urla Peninsula Based on Rapid Assessment Techniques(Turkish Chamber of Civil Engineers, 2026) Karavin, Y.S.; Akdag, N.; Demir, U.This study aims to investigate seismic risk of stone masonry buildings in the Urla Peninsula, a region of historical and architectural significance within İzmir, Türkiye. A total of 100 stone masonry buildings were surveyed and documented with a focus on their architectural characteristics, including construction techniques, material types, structural configurations, and age. Data on the properties of all surveyed buildings are provided in an open-access database. Based on the survey, multiple rapid seismic performance assessment methods were applied to evaluate the vulnerability of these structures. These included: i) FEMA P-154 Rapid Visual Screening, ii) Provisions for the Seismic Risk Evaluation of Existing Buildings under Urban Renewal Law (RBTE-2019), iii) Seismic Vulnerability Index for Vernacular Architecture (SVIVA), and iv) the Masonry Quality Index (MQI). The comparative use of different methods is intended to investigate the relative influence of parameters shaping the seismic performance of the masonry building stock rather than to align their scores. The outcomes of this research are expected to contribute to the current risk mitigation efforts for stone masonry buildings in İzmir, thereby supporting regional seismic resilience planning. © 2026, Turkish Chamber of Civil Engineers. All rights reserved.Article Dissecting the Metabolic Landscape of Breast Cancer Subtypes via Elastic Net Modeling and Examining Its Immune Correlates(Walter de Gruyter GmbH, 2026) Kus, M.E.; Ekiz, H.A.Objectives: Breast cancer is a heterogeneous disease, and the estrogen receptor (ER) status is a key factor in disease classification and treatment planning. While metabolomic profiling has revealed subtype-specific differences, cross-study comparisons have been limited, posing challenges for data extrapolation. This study aims to investigate metabolites that differentiate ER-positive and ER-negative tumors via integrative analyses of multi-omics data. Methods: We jointly analyzed two untargeted metabolomics datasets via elastic net modeling using consistent analysis pipelines tuned for low sample sizes, namely multiple bootstrapping and stability selection. Significant metabolite predictors from two studies were cross-examined to reveal distinctions and commonalities. We also performed differential gene expression analysis using RNA sequencing data from matching samples to link metabolic patterns with transcriptomic signatures and intratumoral immune cell signatures. Results: This study identified unique metabolite signatures in distinct datasets and a limited overlap of discriminating metabolites that can be broadly generalizable for subtyping. Nevertheless, several glycolysis and fatty acid metabolism intermediates exhibited variation depending on the tumor ER status. Consistently, genes related to fatty acid metabolism and glycolysis were enriched in ER-positive and ER-negative tumors respectively. Furthermore, we used multiple immune cell deconvolution algorithms to correlate various immune cell types with the metabolite levels within the tumor microenvironment. Conclusions: Together, these findings highlight the metabolic and immunological diversity of breast cancer and establish a reproducible machine-learning framework for integrating multi-omics data to interrogate tumor complexity. © 2025 the author(s), published by De Gruyter, Berlin/Boston.Article Determining Area Affected by Corona in Lung Computed Tomography Images by Three-Phase Level Set and Shearlet Transform(Wolters Kluwer Medknow Publications, 2025) Aghazadeh, Nasser; Noras, Parisa; Moghaddasighamchi, SevdaBackground:The COVID-19 pandemic has created a critical global situation, causing widespread challenges and numerous fatalities due to severe respiratory complications. Since lung involvement is a key factor in COVID-19 diagnosis and treatment, accurate identification of infected regions in lung images is essential.Methods:We propose a multiphase segmentation method based on the level set framework to determine lunginvolved areas. The shearlet transform, a high-precision directional multiresolution transform, is employed to guide the gradient flow in the level set formulation. Additionally, the phase stretch transform (PST) is applied to enhance the contrast between infected and healthy regions, improving convergence speed during segmentation.Results:The proposed algorithm was tested on 500 lung images. The method accurately identified infected areas, enabling precise calculation of the percentage of lung involvement. The use of the shearlet transform also allowed clear delineation of ground-glass opacity boundaries.Conclusion:The proposed multiphase level set method, enhanced with shearlet and phase stretch transforms, effectively segments COVID-19-infected lung regions. This approach improves segmentation accuracy and computational efficiency, offering a reliable tool for quantitative lung involvement assessment.Article Citation - WoS: 1Citation - Scopus: 1Two Key Substitutions in the Chromophore Environment of mKate2 Produce an Enhanced FusionRed-Like Red Fluorescent Protein(Russian Federation Agency Science & innovation, 2025) Ruchkin, D. A.; Gavrikov, A. S.; Kolesov, D., V; Gorokhovatsky, A. Yu.; Chepurnykh, T., V; Mishin, A. S.; Bogdanov, A. M.Red fluorescent proteins (RFPs) are often probes of choice for living tissue microscopy and whole-body imaging. When choosing a specific RFP variant, the priority may be given to the fluorescence brightness, maturation rate, monomericity, excitation/emission wavelengths, and low toxicity, which are rarely combined in an optimal way in a single protein. If additional requirements such as prolonged fluorescence lifetime and/or blinking ability are applied, the available repertoire of probes could dramatically narrow. Since the entire diversity of conventional single-component RFPs belongs to just a few phylogenetic lines (DsRed-, eqFP578-and eqFP611-derived being the major ones), it is not unexpected that their advantageous properties are split between close homologs. In such cases, a systematic mutagenetic analysis focusing on variant-specific amino acid residues can shed light on the origins of the distinctness between related RFPs and may aid in consolidating their strengths in new RFP variants. For instance, the protein FusionRed, despite being efficient in fluorescence labeling thanks to its good monomericity and low cytotoxicity, has undergone considerable loss in fluorescence brightness/lifetime compared to the parental mKate2. In this contribution, we describe a fast-maturing monomeric RFP designed semi-rationally based on the mKate2 and FusionRed templates that outperforms both its parents in terms of molecular brightness, has extended fluorescence lifetime, and displays a spontaneous blinking pattern that is promising for nanoscopy use.Article Decision-Support Approaches for Sustainable Water Resource Management in Northwest Algeria(Polish Society of Ecological Engineering – PTIE, 2025) Meskine, Ahmed; Cherif, El Amine; Zerouali, Bilel; Ouadja, Abid; Santos, Celso Augusto Guimaraes; Bailek, Nadjem; Baba, AlperThis study investigates water resource management in the Wilaya of Mostaganem, northwest Algeria, using the water evaluation and planning (WEAP) decision support tool in combination with the analytic hierarchy process (AHP). As water scarcity becomes increasingly critical due to population growth, agricultural demands, and climate variability, effective management strategies are essential. This research employs WEAP to simulate various water demand and supply scenarios, assessing the impacts of irrigation efficiency, industrial development, and climate conditions on water availability. Under the ASI scenario, unsatisfied water demand may reach 4.3 hm3 per year by 2027. However, improving irrigation efficiency could reduce this by up to 50% compared to the reference scenario. Seasonal variations reveal deficits reaching 3.2 hm3 per month during the summer months of July through October. Additionally, the study highlights that a significant increase in water demand, exceeding 80 hm3 by 2060, can be mitigated through improved water supply initiatives, such as constructing new dams. The integration of AHP enables the prioritization of management strategies based on stakeholder preferences, demonstrating that adapting to climate change can stabilize demand below 50 million cubic meters. This integrated approach provides valuable insights for policymakers and stakeholders in developing sustainable water resource strategies that address the challenges faced by the Mostaganem region.Article Investigation of the Effect of the Cutting Parameters on Cutting Forces and Tool Wear in the Stack Drilling of a Carbon Fibre-Reinforced Thermoplastic Matrix Composite and Aa7075(Univ Zagreb Fac Mechanical Engineering & Naval Architecture, 2025) Coskun, Ali; Etyemez, Ayhan; Ay, Mustafa; Kurt, Mustafa; Katmer, Sukran; Seker, Ulvi; Nohuz, MineThis study investigate the stack drillability of unidirectional (UD) carbon fibre reinforced thermoplastic matrix PAEK/CF composite and AA7075 plate utilised in aerospace. The effects of the cutting parameters on cutting forces during the drilling process of thermoplastic matrix composites and aluminium materials were experimentally analysed. Drilling operations were carried out on a CNC Vertical Machining Centre under dry-cutting conditions. For three different drill types, three different cutting speeds, and feed rate combinations, a total of 810 holes were drilled in a full factorial experimental design with 30 replicates for each combination. The damage on the hole surfaces on the drilled composite was identified with an optical microscope. The numerical data were obtained in the composite testing laboratory and analysed using Minitab (R) 21.1 statistical software and transformed into graphs. The most suitable drill type and cutting parameters were determined for the drillability of composite with thermoplastic matrix and aluminium (AA7075) plates when stacked.Article Comparative Analysis of Ahp and Swara Methods for Prioritizing Conservation Projects Supported by Heritage Funds: a Case Study From Turkey(Inst Advanced Science Extension, 2025) Avsar, Oncu Basoglan; Ekinci, Kerem; Soker, Ali IkramEffective budget allocation and financial management are vital for preserving cultural heritage, particularly in countries with limited resources. This study focuses on Turkey's Contribution to the Conservation of Built Heritage (CCBH) fund, which supports heritage preservation through government funding. Despite the fund's importance, a structured method for prioritizing project applications is lacking. This research proposes a decision-making framework for assessing and ranking conservation funding requests using Multiple-Criteria Decision-Making (MCDM) methods. The study applies and compares the Analytic Hierarchy Process (AHP) and the Step-Wise Weight Assessment Ratio Analysis (SWARA) to assign weights to assessment criteria. The findings demonstrate that SWARA provides a more efficient and practical approach to prioritizing conservation projects. The proposed framework aims to assist decision-makers and conservation practitioners in optimizing the allocation of funds to safeguard cultural heritage effectively. (c) 2025 The Authors. Published by IASE. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Article Homogeneity Enhancement of Oxide Additives in Boron Carbide by Precipitation Method(University of Novi Sad, Faculty of Technology, 2025) Toksoy, M.F.; Elçi, C.This study elucidates the use of the precipitation method to enhance the uniformity of oxide additives in boron carbide ceramics. Achieving a homogeneous distribution of additives is critical, as higher additive content tends to degrade the mechanical properties of boron carbide. In this research, yttrium and aluminium hydroxide salts were dispersed and incorporated into boron carbide slurry under highly alkaline conditions. The mixture was aged and subsequently calcined to produce metal oxide layers around the boron carbide particles. The additive-to-boron carbide ratio and calcination conditions were systematically varied and the resulting powders were characterized using SEM, EDX and zeta potential analyses. The precipitation method effectively improved additive dispersion, achieving a uniform distribution. Furthermore, samples processed through precipitation exhibited higher densities compared to conventional benchmark samples. © 2025 University of Novi Sad, Faculty of Technology. All rights reserved.Article Experimental Study of Evolution of Breach Resulting From Piping at Upper Part of Earth-Fill Dam(Turkish Chamber Civil Engineers, 2025) Guney, Mehmet Sukru; Tayfur, Gokmen; Bor, Asli; Okan, Merve; Dumlu, Emre; Aklık, PelinPiping and overtopping are the most important causes of earth-fill dam failure. Such dams may erode under seepage, causing a reduction in the structural strength. The aim of this study was to investigate the temporal evolution of the breach and flow rate from the breach resulting from the piping in earth-fill dams. The experiments were carried out at Hydraulics Laboratory of Civil Engineering Department of İzmir University of Economics. The dam was constructed by using a mixture consisting of 85 % sand and 15 % fine (low plasticity clay). In the first scenario a circular tunnel with a diameter of 2 cm was created along the centreline at 6 cm below the dam crest whereas in the second one it was located at the upper edge. Six cameras at different locations recorded the evolution of the progress of the breach formation. The pump flow rate was measured by magnetic flow meter, and the continuity equation was used to calculate the flow rate values from the breach. The time-varied values of the total breach areas were determined using the Gauss Area formula. The image processing method was also applied in the determination of the breach areas. The time-dependent changes of water depth in the channel were also recorded. The obtained experimental findings are presented and commented, together with the universal dimensionless curves. The failure of the dams occurred mainly because of the head cut erosion developed from downstream to upstream. When breaching started, the orifice flow was converted to open channel flow where breach bottom behaved like a broad crested weir. In the second scenario, the rigid lateral side considerably influenced the flow rate and the development of the breach. The peak flow rate corresponding to the first scenario was found approximately 2.3 times greater than that of the second one. The maximum values of all the breach parameters were reached earlier in the case of the seepage along the centerline. The ratios between the values corresponding to the first and the second scenarios were found as 3.25 and 1.75 for maximum breach areas at downstream and at upstream sides, respectively. These ratios were 2.44 and 1.37 for the average breach widths at downstream and upstream sides, respectively. A very good agreement was found between the area values obtained from Gauss area method and image processing technique, in both scenarios. This fact demonstrated that either of these two approaches can be used to determine the time-dependent breach areas. These experimental findings provide the opportunities for the calibration and validation of the numerical models used in the relevant numerical investigations. This study also offers guidance for the strategies concerning emergency action plans related to the failure of homogeneous earth-fill dams when the piping starts at upper part of the homogeneous earth-fill dams.Article Citation - WoS: 1Citation - Scopus: 1Numerical and Experimental Investigation of Aspect Ratio Effect on Aerodynamic Performance of Naca 4415 Airfoil Section at Low Reynolds Number(Assoc Mechanical Engineers Technicians Slovenia, 2025) Uemuetlue, Hatice Cansu Ayaz; Kiral, Zeki; Karadeniz, Ziya HaktanIn this study, the effect of aspect ratio on the aerodynamic coefficients is investigated for a NACA 4415 airfoil profile. Four different aspect ratios which are 3, 5, 7, and 9 are evaluated with the computational fluid dynamics (CFD) simulations and the experiments. The CFD studies are performed using a threedimensional (3D) computational domain and by using the k-omega shear stress transport (SST) turbulence model for turbulence calculations. The measurements of the aerodynamic forces are carried out in open jet type wind tunnel using a three-component balance. CFD and experimental studies are performed at angles of attack from 0 degrees to 25 degrees and Reynolds number 85<middle dot>103. The results show that as the aspect ratio increases, separation points move towards the leading edge of the airfoil and the stall angle reduces. Furthermore, it is observed that the lift coefficients increase with the increasing aspect ratio. The results obtained indicate that there is a harmony between the experimental data and the CFD solutions.