Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Editorial Citation - WoS: 8Citation - Scopus: 9Kras(g12c) Inhibitors on the Horizon(Future Science, 2019) Çağır, Ali; Azmi, Asfar S.RAS proteins (the four isoforms KRAS4A, KRAS4B, NRAS and HRAS encoded by three genes KRAS, NRAS and HRAS) act as molecular switches that when activated drive several key cellular processes such as cell growth, proliferation and survival [1]. In normal cells, RAS activity is under tight control by the precise activation (binding to GTP) and inactivation (GTP hydrolysis to GDP) [1]. As with other critical proteins, it is not at all surprising to note that the gene encoding the RAS protein isoforms is found mutated or altered in a significant proportion of tumors [2]. Mutant RAS loses its ability to hydrolyze GTP and remains in a permanently activated state (bound to GTP) leading to uncontrolled growth.Article Citation - WoS: 3Citation - Scopus: 3One-Pot Vinylogous Aldol Addition of Ss,?-Unsaturated Esters Under Mild Conditions(Royal Society of Chemistry, 2015) Akçok, İsmail; Çağır, AliWe described a one-pot vinylogous aldol addition of methyl 3-butenoate to aromatic aldehydes in the presence of silver salts and the TMSCl-TBAF mixture. The reaction can be done simply by sequentially mixing reagents in situ, and it does not require any catalyst or dienolate ether preparations prior to the reaction.Article Citation - WoS: 7Citation - Scopus: 7Cleavage of Ring a and Formation of an Unusual Nor-Triterpene Skeleton Via the Baeyer-Villiger Reaction(Elsevier Ltd., 2012) Tağ, Özgür; Çağır, Ali; Khan, Ikhlas A.; Bedir, ErdalWith the aim to generate a compound library for our biological screening studies, cycloastragenol was subjected to chemical transformation studies. The Baeyer-Villiger oxidation experiments provided an interesting 3,5-seco-4-nor-triterpene skeleton via ring opening followed by an unusual rearrangement. A new methodology is described for transforming triterpenoids into 3,5-seco-4-nor derivatives.