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Computational Approaches for Antibody-Based Drug Design
(Institute of Physics Publishing, 2024) Gunes, S.; Arkca, I.; Atik, S.B.; Ulucan-Karnak, F.; Sezgin, H.T.; Uyar, A.
This chapter includes various aspects of antibodies with a major emphasis on computational tools in antibody design. In this scope, current antibody databases, computational tools, and approaches for modelling antibodies and nanobodies, the structure, and interface prediction are analyzed. On the other hand, various antibody design techniques such as grafting, the significance of antibody-drug conjugates, and how computational methods contribute to the development of therapeutic antibodies are discussed with relevant strategies in the literature. Lastly, the production cost and the rising market value of antibodies are emphasized. © IOP Publishing Ltd 2023. All rights reserved.

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