Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Bauer, Kaylyn M.Department: search.filters.department.İzmir Institute of Technology

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  • Article
    Characterization and Energetic Property Evaluation of Novel Energetic Salts and Co-Crystals Formed with Nitropyrazoles and Pyridines
    (Amer Chemical Soc, 2025) Atceken, Nurunnisa; Bauer, Kaylyn M.; Nichol, Gary S.; Morrison, Carole A.; Pulham, Colin R.
    Nitropyrazoles are promising candidates to replace conventional explosives as they generally have positive heats of formation, good thermal stabilities, low friction and impact sensitivities and high energetic performance. In this study, 3,5-dinitropyrazole (DNP) and 3,4,5-trinitropyrazole (TNP) were combined with a series of pyridine derivatives to create nine new multicomponent crystals. Single-crystal X-ray diffraction shows that the herringbone-type packing observed in both DNP and TNP can be significantly altered to form puckered, wave-like and layered packing motifs. Differential scanning calorimetry and thermogravimetric analysis measurements show significant alteration in the thermal properties of the new materials, suggesting that the processing and energetic properties of DNP and TNP can be efficiently tuned through multicomponent crystallization. Preliminary impact sensitivity measurements performed on some of the materials also suggest that the mechanochemical responses of DNP and TNP can be altered through changing the crystal packing motifs. Overall, this study highlights the important role that multicomponent crystallization can play in tuning the structure/materials property relationships in energetic materials research.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    A Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+t Cells That Respond To Immunotherapy
    (Cell Press, 2025) Tang, William W.; Battistone, Ben; Bauer, Kaylyn M.; Weis, Allison M.; Barba, Cindy; Fadlullah, Muhammad Zaki Hidayatullah; O'Connell, Ryan M.
    The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8+ T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8+ T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based on an underlying miR-155-dependent CD8+ T cell transcriptional profile, we identify a gene signature that predicts ICI responses across 12 diverse cancers. Together, our findings support a model whereby miR155 serves as a central regulator of CD8+ T cell-dependent cancer immunity and ICI responses that may be leveraged for future therapeutics.