Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 2A Molecularly Imprinted Polymer as Solid Phase Extraction Sorbent for Ketoprofen Determination in Water and Artificial Serum Prior To Hplc(TÜBİTAK - Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, 2022) Shahwan, Talal; Gürel Özyurt, Elif; Özyurt, Ömer; Ölçer, Yekta Arya; Eroğlu, Ahmet Emin; Boyacı, EzelKetoprofen (KET) is an active pharmaceutical compound that has pain relieving and antipyretic effects. Its determination in body fluids and environmental waters is important due to widespread use of the compound. In this study, a selective and reliable method has been developed for the determination of ketoprofen in water and artificial serum using molecularly imprinted polymers (MIPs) as a solid phase extraction sorbent prior to HPLC-DAD detection. The MIP was synthesized by copolymerization of methacrylic acid (MAA) and trimethylpropane trimethacrylate (TRIM) in the presence of ketoprofen as the template. For the sake of comparison, nonimprinted polymer (NIP) was also synthesized under the same experimental conditions without the addition of ketoprofen under the same experimental conditions. Critical extraction parameters such as sample pH, shaking time and sorbent amount were optimized and adjusted to 8.0, 24 h, and 10.0 mg, respectively, for a sample volume of 10.0 mL. MIP showed higher selectivity than NIP towards ketoprofen in an artificial matrix containing another pain relieving drug, ibuprofen, and a cardiovascular drug, metoprolol. The proposed method was successfully applied for the detection of ketoprofen in spiked drinking water, tap water, and artificial serum samples, and showed satisfactory results with respective recoveries of 96.8 % (± 0.8), 93.7% (± 0.6), 62.2% (± 0.6), and 69.9% (± 0.6).Article Citation - WoS: 14Citation - Scopus: 15Chitosan-Immobilized Pumice for the Removal of As(v) From Waters(Springer Verlag, 2014) Turan, Dilek; Kocahakimoğlu, Cemre; Boyacı, Ezel; Sofuoğlu, Sait Cemil; Eroğlu, Ahmet EminA novel sorbent, chitosan-immobilized pumice, has been prepared for the sorption of As(V) from waters prior to its determination by hydride generation atomic absorption spectrometry. The success of the immobilization has been checked with such characterization techniques as scanning electron microscopy, thermal gravimetric analysis, and elemental analysis. Points of zero charge of the sorbents were determined with potentiometric mass titration. Batch-type equilibration studies have shown that the novel sorbent can be employed at a wide pH range resulting in quantitative sorption (>90 %) at pH 3.0-7.0 and greater than 70 % sorption at pH >8.0. These results demonstrate the advantage of immobilizing chitosan onto pumice, because, under the same conditions, pumice displays <20 % sorption toward As(V), whereas chitosan gives approximately 90%sorption only at pH 3.0. The validity of the method was verified through the analysis of ultrapure, bottled drinking, and tap water samples spiked with arsenate; the respective sorption percentages of 93.2 (±0.7), 89.0 (±1.0), and 80.9 (±1.3) were obtained by batch-type equilibration. Arsenic sorption was also examined in the presence of common interfering ions resulting in competing effects of PO3- 4 and NO- 3on As(V) adsorption.