Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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Author: search.filters.author.Diker, HalideDepartment: search.filters.department.İzmir Institute of Technology

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  • Article
    Synthesis, Characterization, Crystal Structure, Electrochemical and Photoluminescence Properties, Dft and Molecular Docking Studies, and Antimicrobial Activities of Two Mononuclear Nickel (II) Complexes With Pyrazole-Derived Ligands
    (Elsevier, 2025) Amin, Mina A.; Diker, Halide; Sahin, Onur; Varlikli, Canan; Soliman, Ahmed A.
    Two octahedral nickel complexes; [Ni(fdtp)2(DMF)2] (1) and [Ni(dcdtp)2(DMF)2] (2), based on 4-((3-fluorophenyl)diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol (fdtp) and 4-((2,4-dichlorophenyl)diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol (dcdtp) were synthesized. The complexes were characterized spectroscopically (FTIR, UV-Vis, Photoluminescence), Mass spectrometry, elemental analyses, electrochemically, thermally, and through Single-crystal X-ray investigations. The formation of the complexes was confirmed by the existence of Ni-O and Ni-N vibrations at bonds were observed as weak bands at 526-497 and 470-438 cm-1. According to the thermogravimetric analyses, the complexes were thermally stable and had relatively high activation energies (585.81 and 730.07 kJ mol-1 for 1, and 2, respectively). Cyclic voltammograms showed that the anodic potential region of 1 and 2 exhibited two irreversible oxidation peaks at 1.34 V &1.55 V and 1.41 V & 1.63 V, respectively, attributed to metal-localized oxidation. The complexes showed enhanced antibacterial activities compared to free ligands and comparable to the standard. The inhibition zones exhibited via 1 were about 21.7, 19.3, and 26.7 mm versus Escherichia coli (E. coli), Staphylococcus aureus (S. Aureus), and Bacillus Subtits (B. Subtits), respectively. Docking studies supported the antibacterial investigations; the binding energies of the complexes were -8.81 and -9.69 kcal/mol for 1 and 2 respectively, against E. coli (PDB ID: 6F86).
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    New Copper and Cobalt Complexes Based on a Fluorinated Pyrazole Derivative, Synthesis, Characterization and Antibacterial Activity
    (Wiley, 2025) Amin, Mina A.; Diker, Halide; Sahin, Onur; Varlikli, Canan; Soliman, Ahmed A.
    Two copper and cobalt complexes based on 3-(trifluoromethyl)-4-((3-(trifluoromethyl)phenyl)diazenyl)-1H-pyrazol-5-ol (Httdp) have been prepared and characterized using different physicochemical techniques. The crystal structure of the copper complex has been proven to be a square pyramidal, and the cobalt complex has an octahedral structure. DFT calculations of the complexes were performed, and the energy gaps between the HOMO-LUMO of the complexes (-3.38676 to -3.18138 eV) and the Cu (II) complex reflect a higher relative stability compared with Httdp and the Co (II) complex. The antibacterial activities of the two complexes were evaluated. The Co (II) complex demonstrated the highest antibacterial activity against various bacteria compared with Httdp and the Cu (II) complex. The mean inhibition zones exhibited by the Co (II) complex showed the highest activities toward the Gram-negative bacterial strains with mean inhibition zones of 30.3 +/- 0.6 (Staphylococcus aureus) and 25.7 +/- 0.6 (Bacillus subtilis) mm. Docking studies were carried out using S. aureus tyrosyl-tRNA synthetase (PDB ID: 1JIJ) to assess the antimicrobial activities, proving that the complexes were efficient for the protein.