Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Kazemi, SamanWoS Q: search.filters.wosQuartile.Q2

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  • Article
    Citation - WoS: 4
    Citation - Scopus: 3
    Exploration of Electrostatics Effect on Dispersion and Coating Mechanisms in Dry Powder Inhalers by Discrete Element Method
    (Elsevier, 2025) Saeid, Pooya; Kazemi, Saman; Zarghami, Reza; Sotudeh-Gharebagh, Rahmat; Mostoufi, Navid
    Improving drug delivery in the respiratory system relies on the effective coating and dispersion of active pharmaceutical ingredients (APIs) in dry powder inhalers (DPIs) and the respiratory system's airways. This study aims to explore the impact of different factors on coating APIs on carrier particles, considering electrostatic and van der Waals forces using the discrete element method (DEM). This study focuses on the critical elements of API dispersion, specifically collisions between API-coated carrier particles with each other and DPI walls. The factors influencing the dispersion ratio in these collisions, such as impact velocity, contact angle, and particle charge, are examined. Additionally, a reduced-scale shaking DPI with three frequencies is used to investigate the API coating mechanism on carriers, which was not explored in previous studies. The difference in work function between carrier particles and APIs generates charge in the shaking DPI due to collisions. This causes electrostatic force to dominate over van der Waals force, breaking agglomerates and attaching APIs to carrier particles. This study shows that the amount of generated charge increases with particle collisions and that charge distribution becomes more balanced over time through charge exchange between particles. By elucidating the relationships among impact velocity, dispersion ratio, shaking frequency, and contact angles, this study paves the way for future research on more efficient DPI designs.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 6
    Effect of external electric field on fluidization of rodlike particles using CFD-DEM
    (American Chemical Society, 2024) Kazemi, Saman; Aali, Hamed; Larijani, Roxana Saghafian; Zarghami, Reza; Liu, Helei; Mostoufi, Navid
    Given the significant impact of an external electric field on fluidized bed hydrodynamics and the practical importance of rodlike particles, this study examines the behavior of a fluidized bed containing rodlike particles under various external electric fields. Simulations were performed using a coupled computational fluid dynamics-discrete element method, and rodlike particles were generated using a multisphere approach aided by quaternions. The effect of different vertical and horizontal external electric fields on the orientation of particles was investigated. Also, the effect of particle size on their orientation in the presence of constant vertical and horizontal external electric fields was explored in this work. The results showed that increasing the electric field strength and reducing the size of rodlike particles lead to an increment in the tendency of particles to become oriented along the direction of the electric field. Moreover, the effect of the external electric field at various inlet gas velocities on the probability distribution of the porosity in the bed was studied. Finally, the effect of vertical and horizontal electric fields on the bubble diameter was examined. This study offers a deeper understanding of the fluidization of rodlike particles in the presence of an electric field, and its findings can be applied to design and optimize related processes.