Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Book Part Citation - Scopus: 3Tissue Engineering Applications of Marine-Based Materials(Springer, 2022) Polat, Hürriyet; Zeybek, Nuket; Polat, MehmetTissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.Conference Object Solution of the Non-Linear Poisson Boltzmann Theory for the General Case of Dissimilar Double Layers(2006) Polat, MehmetCalculation of the surface potentials, surface charges or electrostatic pressure for interacting colloidal particles is exceedingly important in mineral processing, environmental engineering, ceramic sciences, etc. Such calculations require solving the non-linear Poisson-Boltzmann theory at each plate separation. Though approximate analytical solutions of this theory are available for simplified cases, a general, but compact analytical solution is yet to be developed. A solution with no restrictions on surface potentials or charges is developed in this paper. The expressions developed are straightforward and require as input only the surface potentials at infinite separations.Book Part Citation - Scopus: 6Recent Advances in Chitosan-Based Systems for Delivery of Anticancer Drugs(Springer, 2020) Polat, Mehmet; Polat, HürriyetProblems in transporting drug molecules to tumor sites in required dose or constitution lead to low efficacy and significant side effects. Shielding the drug molecules in micelles, liposomes, or nanoparticles is a major line of investigation to improve chemotherapeutic treatment. Though compatibility for proper envelopment of the drug and timely release at the tumor site are required of such a carrier, protecting its own physicochemical and morphological integrity during transport is another precondition. Because of its superior polymerization capability, biocompatibility, pH dependence, and charging characteristics, chitosan has been in the forefront of potential drug carriers. Numerous synthesis routes for chitosan-based nanocarriers have been suggested to the extent that a search of the literature published since 2000 with the keywords “novel + nano + chitosan” in the title results in 527 articles, indicating the bewildering quality and quantity of the new information. This review was carried out not only to peruse this large amount of work on chitosan-based anticancer drug delivery but also to extract manageable patterns from numerous synthesis routes. The main conclusion is that the synthesis methods suggested in literature can be combined into two main routes, and the degree of hydrophobicity of the drug determines which route should be followed. © Springer Nature Singapore Pte Ltd. 2019.Conference Object Citation - Scopus: 3Characterization of Polysulfone Based Hemodialysis Membranes by Afm(Elsevier Ltd., 2012) Uz, Metin; Yaşar Mahlıçlı, Filiz; Polat, Mehmet; Alsoy Altınkaya, SacideMost of the hemodialysis membrane materials are hydrophobic in nature and allow protein adsorption on the surface easily due to hydrophobic interaction between membrane surface and protein molecules when in contact with blood. Adsorbed proteins can affect platelet and leukocyte adhesion, and modulate the response of plasmatic reactions followed by the activation of different defense systems in blood (Sun et al. 2003).