Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Sahin, HasanDepartment: search.filters.department.Izmir Institute of Technology

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  • Article
    Citation - WoS: 2
    Citation - Scopus: 3
    Development of Mg-Alginate Based Self Disassociative Bio-Ink for Magnetic Bio-Patterning of 3d Tumor Models
    (Wiley-v C H verlag Gmbh, 2024) Coban, Basak; Baskurt, Mehmet; Sahin, Hasan; Arslan-Yildiz, Ahu
    Alginate forms a hydrogel via physical cross-linking with divalent cations. In literature, Ca2+ is mostly utilized due to strong interactions but additional procedures are required to disassociate Ca-alginate hydrogels. On the other hand, Mg-alginate hydrogels disassociate spontaneously, which might benefit certain applications. This study introduces Mg-alginate as the main component of a bio-ink for the first time to obtain 3D tumor models by magnetic bio-patterning technique. The bio-ink contains magnetic nanoparticles (MNPs) for magnetic manipulation, Mg-alginate hydrogel as a sacrificial material, and cells. The applicability of the methodology is tested for the formation of 3D tumor models using HeLa, SaOS-2, and SH-SY5Y cells. Long-term cultures are examined by Live/dead and MTT analysis and revealed high cell viability. Subsequently, Collagen and F-actin expressions are observed successfully in 3D tumor models. Finally, the anti-cancer drug Doxorubicin (DOX) effect is investigated on 3D tumor models, and IC50 values is calculated to assess the drug response. As a result, significantly higher drug resistance is observed for bio-patterned 3D tumor models up to tenfold compared to 2D control. Overall, Mg-alginate hydrogel is successfully used to form bio-patterned 3D tumor models, and the applicability of the model is shown effectively, especially as a drug screening platform.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Thickness-Dependent Characteristics and Oxidation of 2d-Cadmium
    (Royal Soc Chemistry, 2024) Gulucu, Arda; Sahin, Hasan
    In this study, the structural, electronic, and vibrational properties of the thinnest crystal structure that can be obtained by thinning bulk Cd down to a monolayer are investigated by performing first-principles calculations. Total energy optimization and dynamic stability calculations reveal that the single layer crystal structure has a hexagonal unitcell with a two-atomic basis where alternating layers are formed by trigonal arrangements of Cd atoms. Softening occurs with decreasing zone center optical phonon frequencies as a result of structural relaxation when going from a bulk to a single layer (SL) structure. It is also shown that the thinnest structure obtained from bulk Cd crystals maintains its metallic features despite the dimensional crossover. In addition, it is predicted through calculations that the SL Cd crystal strongly interacts with oxygen and that the oxidized regions even undergo chemical transformation to form a CdO crystal. In the double-layer CdO crystal resulting from the oxidation of individual Cd layers, the layers are connected to each other with partially covalent bonds, and this structure is a semiconductor with a band gap of 2.10 eV. On the one hand, the robust metallic structure of the thinnest possible Cd crystal provides flexibility for its use in nanoscale applications, on the other hand, the fact that its electronic properties can be changed by oxidation is important for optoelectronic device applications. In this study, the structural, electronic, and vibrational properties of the thinnest crystal structure that can be obtained by thinning bulk Cd down to a monolayer are investigated by performing first-principles calculations.