Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 3Citation - Scopus: 3Synthesis and Antifungal and Antibacterial Bioactivities of Diborolanes Containing Arylamines(Elsevier, 2023) Aygün, Muhittin; Sevinçek, Resul; Özgener, Hüseyin; Bıyık, Hacı Halil; Metin, Kubilay; Şahin, Yüksel; Poyrazoğlu Çoban, Esra; Gürbüz, BurçinA good yield of 1,2-diarylamino-1,2-diborolanes 2 was obtained from the reaction of 1,2-dichloro-1,2-diborolane 1 and ArNHLi (an anilide). The structures of these new derivatives were characterized by nuclear magnetic resonance spectroscopy. The molecular structures of 2a and 2b were also determined using single-crystal X-ray diffraction. Antimicrobial activities of synthesized compounds against some Gram-positive and -negative bacteria and yeasts were determined. Some compounds were found to have strong antibacterial and antifungal properties, especially against the bacterium, S. pneumonia, which is the causative agent of pneumonia, and the fungus, C. albicans, which is the causative agent of candidiasis. The compounds 2a and 3 had a powerful effect (compound 2a and 3 = 1 μgmL−1) against S. pneumoniae ATCC 27336 bacteria. In addition, compounds 2a, 3 and 2f were observed to have strong effects (compound 2a, 3, 2f = 2 μgmL−1) against C. albicans ATCC 10231 and C. utilis ATCC 9950. The results obtained were found to be more effective than the MIC values (128–64 μgmL−1) of Streptomycin and Flukanozol drugs used for bacteria and yeasts. The results of our study show that the synthesized substances can be used for new drug applications that are being developed against infectious diseases in the pharmaceutical industry. © 2023 Elsevier B.V.Article Citation - WoS: 5Citation - Scopus: 5Synthesis and Structures of 1,3,2,4,5-Diazatriborolidines(Elsevier, 2019) Fırıncı, Erkan; Sevinçek, Resul; Bursalı, Banu; Özgener, Hüseyin; Burgaz, Osman; Şen, Ceren; Şahin, YükselThe derivatives of diazatriborolidine are a class of 5-membered heterocyclic compounds containing a ring with two nitrogen atoms and three boron atoms. The 1,3,2,4,5-diazatriborolidine derivatives were synthesized from 1,2-bis(N-lithium-arylamino) diborane(4) and dichloro-dimethylaminoborane with high yield. The structures of these new derivatives were determined using nuclear magnetic resonance (NMR) spectroscopy. The molecular structures of 3a, 3b, 3d, 4b and 4c were determined using single-crystal X-ray diffraction. Their structural features were discussed and compared with similar diazatriborolidines. In addition, the enthalpy of formation of B and N atoms containing five membered heterocycles were calculated theoretically for the first time. Also, an easy and efficient synthesis route has been reported for preparation of 1,3,2,4,5-diazatriborolidine derivatives.