Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Projectivity and Quasi-Projectivity With Respect To Epimorphisms To Simple Modules
    (World Scientific Publ Co Pte Ltd, 2025) Alagoz, Yusuf; Alizade, Rafail; Buyukasik, Engin
    Using the notion of relative max-projectivity, max-projectivity domain of a module is investigated. Such a domain includes the class of all modules whose maximal submodules are direct summands (this class denoted as MDMod -R). We call a module max-p-poor if its max-projectivity domain is exactly the class MDMod -R. We establish the existence of max-p-poor modules over any ring. Furthermore, we study commutative rings whose simple modules are projective or max-p-poor. Additionally, we determine the right Noetherian rings for which all right modules are projective or p-poor. Max-p-poor abelian groups are fully characterized and shown to coincide precisely with p-poor abelian groups. We also further investigate modules that are max-projective relative to themselves, which are known as simple-quasi-projective modules. Several properties of these modules are provided, and the structure of certain classes of simple-quasi-projective modules is determined over specific commutative rings including the ring of integers and valuation domains.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 9
    A Holistic Overview of the Applications of Grace-Observed Terrestrial Water Storage in Hydrology and Climate Science
    (Springer, 2025) Khorrami, Behnam; Gunduz, Orhan
    Terrestrial Water Storage (TWS) represents a vital element of the hydrological cycle, with its fluctuations significantly impacting the climate of the Earth and its ecological balance. Since its launch in 2002, the Gravity Recovery and Climate Experiment (GRACE) satellite mission has revolutionized the ability to observe and analyze large-scale mass changes within Earth's system components. This paper offers a comprehensive and current overview of GRACE satellite gravimetry, highlighting its relevance to hydrological and climate-related studies. It outlines the fundamental measurement principles of the GRACE mission, provides an in-depth explanation of GRACE data products (including spherical harmonic and mascon solutions), examines emerging trends in GRACE-based research, and reviews key applications in hydrology and climate science. Additionally, it addresses the major challenges in utilizing GRACE data and explores promising avenues for future research and applications.
  • Article
    Biologically Informed Decision-Making for PMRT in PT3N0M0 Luminal Breast Cancers (Protocol MF22-02): International Multicenter Real-World Data
    (Cig Media Group, Lp, 2025) Soran, Atilla; Gultekin, Melis Bahadir; Venkatesulu, Bhanu Prasad; Barry, Parul Nafees; King, Caleb; Bhargava, Rohit; Vargo, John Austin
    Two hundred and 2 women from 16 centers with pT3N0M0 hormone receptor (HR) positive, HER2 negative BC who underwent mastectomy were retrospectively analyzed. Patients were divided into 2 groups: PMRT (n = 130) and no PMRT (n = 69). Groups were compared in terms of overall survival (OS), loco-regional recurrence (LRR) rate, and distant metastases (DM) in light of Magee Equations Score (MS). At a median follow-up of 51.3 months for the no PMRT group and 65.9 months for the PMRT group (P =.041), 9% (n = 6) of patients from the no PMRT group and 2% (n = 3) from the PMRT group developed LRR (P = 0.047). There was no difference in local recurrence (1% in no PMRT group vs. 2% in PMRT group; P =.7) and distant recurrence (7% in no PMRT group vs. 3% in PMRT group; P =.16) in patients who received PMRT and no PMRT. Further comparison of the LRR in the no PMRT and PMRT groups in patients with an MS < 18 did not show a significant difference (3% vs. 4%; P =.64). However, among patients with an MS >= 18, no PMRT group had a higher LRR rate compared to the PMRT group (11% vs. 2%; P =.01). In patients with an MS >= 18, the administration of PMRT correlates with statistically significantly better LRR-free survival (HR 0.19; 95% CI 0.05-0.79; P =.02). Patients with MS <18 experience a comparable rate of recurrence irrespective of PMRT, while those with MS >= 18 have higher rates of LRR and thus should not omit PMRT. Background: Current guidelines do not list definitive recommendations for postmastectomy radiation therapy (PMRT) in patients with luminal pT3N0M0 breast cancer (BC). Increased data suggests de-escalation of radiation therapy (RT) in genomically defined biologically favorable luminal BCs. The goal of this study is to determine whether PMRT can be safely omitted for this specific subgroup of patients. Methods and materials: Two hundred and 2 women from 16 centers with pT3N0M0 hormone receptor (HR) positive, HER2 negative BC who underwent mastectomy were retrospectively analyzed. No patients received neoadjuvant chemotherapy. Three patients were excluded because of positive surgical margins. Patients were divided into 2 groups: PMRT (n = 130) and no PMRT (n = 69). Groups were compared in terms of overall survival (OS), loco-regional recurrence (LRR) rate, and distant metastases (DM) in light of the Magee Equations Score (MS), menopausal status/age, axillary surgery, pathology, lymphovascular invasion (LVI), adjuvant chemotherapy, and adjuvant endocrine therapy. Results: The majority of the patients had invasive ductal carcinoma (49%, n = 98). There was no significant difference regarding tumor size, axillary surgery, and adjuvant endocrine therapy between the 2 groups (P =.82, P =.28, P =.12, respectively). LVI was 19% (n = 39), and it was greater in the PMRT group (25% vs. 10%; P =.01). Patients in the PMRT group received more chemotherapy (66% vs. 30%; P <.001), had more grade 3 tumors (28% vs. 9%, P =.005), and were more premenopausal (49% vs. 22%; P =.0001). At a median follow-up of 51.3 months for the no PMRT group and 65.9 months for the PMRT group (P =.041), 9% (n = 6) of patients from the no PMRT group and 2% (n = 3) from the PMRT group developed LRR (P =.047). There was no difference in local recurrence (1% in no PMRT group vs. 2% in PMRT group; P =.7) and distant recurrence (7% in no PMRT group vs. 3% in PMRT group; P =.16) in patients who received PMRT and no PMRT. Further comparison of the LRR in the no PMRT and PMRT groups in patients with an MS < 18 did not show a significant difference (3% vs. 4%; P =.64). However, among patients with an MS >= 18, no PMRT group had a higher LRR rate compared to the PMRT group (11% vs. 2%; P =.01). In patients with an MS >= 18, the administration of PMRT correlates with statistically significantly better LRR-free survival (HR 0.19; 95% CI 0.05-0.79; P =.02). Conclusions: Our findings imply that when considering PMRT for patients with pT3N0M0, HR-positive, and HER2-negative BC, clinicians can benefit from a combination of pathological risk factors and recurrence prediction models. Patients with MS < 18 experience a comparable rate of recurrence irrespective of PMRT, while those with MS >= 18 have higher rates of LRR and thus should not omit PMRT. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
  • Article
    Assessment of Cytotoxic Potentials of Isoindole-Derived Compounds With Epoxy Alcohol Functionalities on Different Cancer Cell Lines and Molecular Docking Analysis
    (Maik Nauka/Interperiodica/Springer, 2025) Yetiskin, Egehan; Gundogdu, Ozlem; Mete, Derya; Kishali, Nurhan H.; Kara, Yunus; Sanli-Mohamed, Gulsah
    Objective: Isoindoline and epoxycyclohexane derivatives are known to exert beneficial effects on various inflammatory pathologies, including cancer. This study uniquely evaluates the cytotoxic potential of four synthesized isoindoline derivatives against five different cancer cell lines. Methods: Cancer cell lines were treated with varying concentrations of each derivative and incubated for 24, 48, and 72 h. Cytotoxicity was assessed via cell growth inhibition assays and cell membrane damage tests. Additionally, molecular docking studies were conducted to examine the interaction of the compounds with key cancer-related proteins: human tankyrase 1, c-MET, estrogen receptor alpha, androgen receptor, and EGFR. Results and Discussion: The epoxy alcohol derivatives demonstrated a dose-dependent cytotoxic effect, inhibited cell proliferation, and induced membrane damage in adenocarcinoma cell lines. Apoptosis rates and in vitro wound healing assays further supported their antiproliferative potential. Conclusions: These findings suggest that epoxy isoindole derivatives may serve as promising anticancer agents for the treatment of cervical, lung, prostate, and breast cancers due to their cytotoxic and antiproliferative activities. Molecular docking results corroborated their potential mechanism of action.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 1
    Phase Transition Behavior in Ferroelectric BaTi0.8Zr0.2O3: Evidence of Polar Cluster Reorientation Above Curie Temperature
    (Aip Publishing, 2025) Aktas, Oktay; Romero, Francisco Javier; He, Zhengwang; Linyu, Gan; Ding, Xiangdong; Martin-Olalla, Jose-Maria; Lookman, Turab
    We study the phase transition behavior of the ferroelectric BaTi0.8Zr0.2O3 in the paraelectric region above the Curie temperature. The investigation of the phase transition using caloric, dielectric, and elastic measurements indicates that the ferroelectric transition at T-c = 292 K is continuous and displays weakly relaxor characteristics. The nonlinear scaling of entropy and polarization, as well as the temperature dependencies of dielectric and elastic properties, indicates the presence of local structures in the paraelectric phase. The non-zero remnant polarization is measured up to a characteristic temperature T* similar to 350 K. This temperature coincides with the temperature where the dielectric constant deviates from the Curie-Weiss law and is identified as the coherence temperature T*, associated with the formation of static polar nanostructures. Finally, direct current field cooling in the paraelectric phase using fields smaller than the coercive field leads to an elastic response and remnant piezoelectricity below T*, attributed to the re-orientation of polar nanostructures. The observed remnant effect, along with the temperature dependence of the piezoelectric effect and its time dependence below and above T*, is consistent with increased coherence and slower dynamics of these structures on cooling, leading to symmetry-disallowed remnant piezoelectricity due to glassy behavior below T*.
  • Article
    Citation - WoS: 2
    Vis-Assist: Computer Vision and Haptic Feedback-Based Wearable Assistive Device for Visually Impaired
    (Springer, 2025) Dede, Ibrahim; Gumus, Abdurrahman
    Visual impairment affects millions of people worldwide, posing significant challenges in their daily lives and personal safety. While assistive technologies, both wearable and non-wearable, can help mitigate these challenges, wearable devices offer the advantage of hands-free operation. In this context, we present Vis-Assist, a novel wearable visual assistive device capable of detecting and classifying objects, measuring their distances, and providing real-time haptic feedback through a vibration motor array, all using an integrated low-cost computational unit without the need for external servers. Our study distinguishes itself by utilizing haptic feedback to convey object information, allowing visually impaired individuals to discern between 19 different object classes following a brief training period. Haptic feedback offers an alternative to audio that doesn't block hearing and can be used alongside it, serving as a complementary solution. The performance of the developed wearable device was evaluated through two types of experiments with four participants. The results demonstrate that users can identify the location of objects and thereby prevent collisions with obstacles. The experiments conducted demonstrate that users, on average, can locate a predefined object, such as a chair, within a 40 m2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {m}<^>{2}$$\end{document} vacant space in under 94 seconds. Furthermore, users exhibit proficiency in finding objects while navigating around obstacles in the same environment, achieving this task in less than 121 seconds on average. The system developed here has high potential to help the self-navigation of visually impaired people and make their daily lives easier. To facilitate further research in this field, the complete source code for this study has been made publicly available on GitHub.
  • Article
    Influence of Soil Characteristics on the Phytochemistry of Evergreen Ivy (Hedera Helix L.) Leaves in Deciduous Forests
    (Wiley-v C H verlag Gmbh, 2025) Yildirim, Elif Begum; Ozer, Gulcin; Sen, Nisa Beril; Ozdemir, Emrah; Makineci, Ender; Ozdemir, Durmus; Guzelmeric, Etil
    The evergreen ivy (Hedera helix L.), traditionally used to treat respiratory conditions, contains triterpene saponins, primarily hederacoside C, and various phenolic compounds. This study investigated the relationships between the chemical composition of ivy leaves and their natural growing conditions (moisture, temperature, pH, and electrical conductivity of soil). Ivy leaves were collected monthly over 1 year from oak and beech forests. Hederacoside C, rutin, chlorogenic acid (ChA), neoChA, 4,5-dicaffeoylquinic acid (DCQA), and 3,5-DCQA were analyzed by high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC). Soil parameter data, along with the quantitative HPLC results of ivy leaves, were first subjected to bivariate analysis, which revealed significant correlations, particularly between soil moisture, soil temperature, and the chemical composition of ivy leaves. In addition, ivy samples were classified and clustered based on seasons by principal component analysis (PCA) and hierarchical cluster analysis (HCA), regardless of their collection sites. Digitized HPTLC chromatograms were evaluated by PCA and partial least squares discriminant analysis (PLS-DA) analyses; PCA enabled the grouping of ivy leaves based on their collection sites, and PLS-DA categorized the samples by seasons. The evaluation of the relationships between the phytochemistry of ivy leaves and their natural growing conditions has been reported for the first time.
  • Article
    Rings Whose Mininjective Modules Are Injective
    (Taylor & Francis inc, 2025) Alagoz, Yusuf; Benli-Goral, Sinem; Buyukasik, Engin; Garcia Rozas, Juan Ramon; Oyonarte, Luis
    The main goal of this paper is to characterize rings over which the mininjective modules are injective, so that the classes of mininjective modules and injective modules coincide. We show that these rings are precisely those Noetherian rings for which every min-flat module is projective and we study this characterization in the cases when the ring is Kasch, commutative and when it is quasi-Frobenius. We also treat the case of nxn upper triangular matrix rings, proving that their mininjective modules are injective if and only if n=2. We use the developed machinery to find a new type of examples of indigent modules (those whose subinjectivity domain contains only the injective modules), whose existence is known, so far, only in some rather restricted situations.
  • Article
    Fabrication of Flexible Nanoporous Platinum Films Via One-Pot Liquid Crystal Templated Synthesis
    (Amer Chemical Soc, 2025) Demir, Seren; Polat, Pelin; Tertemiz, Necip Ayhan; Vural, Beyza; Babahan, Elian Melissa; Orhan, Ozan Baran; Balci, Fadime Mert
    Nanoporous platinum (NPP) thin films are crucial for applications in electrocatalysis, fuel cells, nanophotonics, and gas sensing. Conventional fabrication methods, such as dealloying, often leave residual elements that degrade the performance of the NPP thin films in applications such as electrocatalysis. In this study, for the first time, we introduce a novel method to fabricate ultrapure, flexible, large-area NPP thin films through a one-pot, liquid crystal-templated synthesis. A hexagonal lyotropic liquid crystal (LLC) phase, composed of a strong acid, a nonionic surfactant, water, and hexachloroplatinic acid, serves as a template. The LLC films, prepared with hexachloroplatinic acid concentrations of 0.1-0.5 M, exhibit distinct optical textures under a polarizing optical microscope and display low-angle diffraction patterns when analyzed with an X-ray diffractometer. Calcination at 450 degrees C yields ultrapure, conductive, and black colored NPP films. Importantly, we fabricate freestanding NPP thin films and successfully transfer them onto both rigid and flexible substrates. Bending tests reveal that a four-layer flexible NPP film having a thickness of around similar to 174 nm maintains a stable sheet resistance (similar to 30 ohm/sq) after several hundred bend cycles (1000 cycles). These findings highlight the potential of ultrapure NPP films with high nanopore and ligament density for applications in electrocatalysis, fuel cells, gas sensors, broadband absorbers, bioelectronics, and flexible electronics.
  • Article
    Effect of Methionine and Lysine Supplementation on Performance and Intestinal Morphometrics of Finisher Broiler Chickens Fed Diets Containing Processed Cassava Peel Meal
    (CSIRO Publishing, 2025) Adebowale, T.O.; Arowolo, M.A.; Adekola, M.; Adeleye, T.; Oke, O.E.
    Context: The current high prices of conventional feedstuffs in developing countries seems to warrant intensified efforts to find sustainable alternatives to the major feed ingredients that would support performance without compromising gut health, reduce cost of production and promote a sustainable environment. Aims: The aim of the study is to evaluate the performance and health-related responses of finisher broiler chickens to the dietary replacement of corn with processed cassava peel meal (high- quality cassava peel meal) at 50% inclusion level, supplemented with methionine and lysine. Methods: Three hundred and twenty Cobb500 broiler chickens were allocated to four dietary treatments on a weight equalization basis. Each treatment was replicated eight times. A control diet based on corn and soybean meal was formulated to meet the recommended digestible methionine and lysine specification of 4.0 and 0.96 g kg−1respectively (VenCobb 500 Broiler Management Guide, Cobb-Vantress Inc., Siloam Spring, AR) for the finisher phase. The corn in the control diet was replaced with cassava peel meal at 50% replacement level in three other treatments (Diet 2–4). Diets 2–4 were then formulated to contain 100%, 112.5% and 125% of the recommended digestible methionine and 100%, 106.25% and 112.5% of the recommended digestible lysine, yielding 4.0, 4.4, and 4.8 g kg−1digestible methionine respectively, and 0.96, 1.02, and 1.08 g kg−1digestible lysine respectively, for the finisher phase. Key results: The highest bodyweight gain, improved feed conversion ratio and increased duodenal and jejunal villus height:crypt depth ratio was found in birds fed Diet 4. The lactobacillus count was highest in birds fed Diet 4 and total bacteria counts was highest in birds fed Diet 2. The feed cost per kilogram weight gain was least for the birds fed diets containing the processed cassava peel meal. However, morphological changes were observed in the liver and intestinal tissues of the birds. Conclusion: The study showed that the adequate supplementation of methionine and lysine to processed cassava peel meal can improve production performance of finisher broiler chickens but may not prevent morphological changes in the liver and intestine of the birds. Implication: The result implied that processed and fortified cassava peel meal can reduce high dependence on maize in the production of finisher broiler chickens, while mitigating the enviromental challenges associated with the disposal of the agrowaste. The morphological changes in the liver and intestine of the birds require further investigation. © 2025 Elsevier B.V., All rights reserved.