Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 3Citation - Scopus: 3Roadmap on Multifunctional Materials for Drug Delivery(IOP Publishing, 2024) Nottelet, Benjamin; Buwalda, Sytze; van Nostrum, Cornelus F.; Zhao, Xiaofei; Deng, Chao; Zhong, Zhiyuan; Cheah, Ernest; Kehr, Nermin SedaThis Roadmap on drug delivery aims to cover some of the most recent advances in the field of materials for drug delivery systems (DDSs) and emphasizes the role that multifunctional materials play in advancing the performance of modern DDSs in the context of the most current challenges presented. The Roadmap is comprised of multiple sections, each of which introduces the status of the field, the current and future challenges faced, and a perspective of the required advances necessary for biomaterial science to tackle these challenges. It is our hope that this collective vision will contribute to the initiation of conversation and collaboration across all areas of multifunctional materials for DDSs. We stress that this article is not meant to be a fully comprehensive review but rather an up-to-date snapshot of different areas of research, with a minimal number of references that focus upon the very latest research developments.Article Citation - WoS: 9Citation - Scopus: 8Development of a New Electrochemical Sensor Based on Molecularly Imprinted Biopolymer for Determination of 4,4'-methylene Diphenyl Diamine(MDPI, 2023) Ghaani, Masoud; Büyüktaş, Duygu; Carullo, Daniele; Farris, StefanoA new molecularly imprinted electrochemical sensor was proposed to determine 4,4' methylene diphenyl diamine (MDA) using molecularly imprinted polymer-multiwalled carbon nanotubes modified glassy carbon electrode (MIP/MWCNTs/GCE). GCE was coated by MWCNTs (MWCNTs/GCE) because of their antifouling qualities and in order to improve the sensor sensitivity. To make the whole sensor, a polymeric film made up of chitosan nanoparticles was electrodeposited by the cyclic voltammetry method on the surface of MWCNTs/GCE in the presence of MDA as a template. Different parameters such as scan cycles, elution time, incubation time, molar ratio of template molecules to functional monomers, and pH were optimized to increase the performance of the MIP sensor. With a detection limit of 15 nM, a linear response to MDA was seen in the concentration range of 0.5-100 mu M. The imprinting factor (IF) of the proposed sensor was also calculated at around 3.66, demonstrating the extremely high recognition performance of a MIP/MWCNT-modified electrode. Moreover, the sensor exhibited good reproducibility and selectivity. Finally, the proposed sensor was efficiently used to determine MDA in real samples with satisfactory recoveries ranging from 94.10% to 106.76%.Article Citation - WoS: 10Citation - Scopus: 12Transparent block copolymer thin films for protection of optical elements via chemical vapor deposition(Elsevier Ltd, 2018) Karabıyık, Merve; Ebil, ÖzgençIn this study, glycidyl methacrylate and 1H, 1H, 2H, 2H-perfluorodecyl acrylate copolymer p(GMA-co-PFDA) thin-films fabricated via Initiated Chemical Vapor Deposition (iCVD) were investigated as protective coatings on optical BK7 glass substrates and commercial optical filters. Durability tests based on military standards MIL-F-48616 and MIL-C-48497A were performed to evaluate performance of coatings for the protection of surfaces of optical elements. Cross-linked p(GMA-co-PFDA) copolymer coatings successfully passed all durability tests showing excellent mechanical properties and protection against humidity, salt water, swelling in water, and resistance to organic solvents while providing excellent adhesion to substrate. iCVD process enabled fine tuning of film morphology, mechanical properties and hydrophobicity by controlling the process parameters. Fabricated films were hydrophobic and highly transparent (>98%) in the wavelength range from 300 nm to 1000 nm. Optical transmittance measurements before and after coating process proved that while providing chemical and physical protection, p(GMA-co-PFDA) copolymer thin-films do not cause any detectable change in optical performance of commercial narrow band and wide band filters.Article Citation - WoS: 23Citation - Scopus: 27Novel Poss Reinforced Chitosan Composite Membranes for Guided Bone Tissue Regeneration(Springer Verlag, 2018) Tamburacı, Sedef; Tıhmınlıoğlu, FundaIn this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS® nanofiller to the chitosan matrix increased the surface roughness, protein adsorption and swelling capacity of membranes. The addition of POSS enhanced significantly the ultimate tensile strength and strain at break of the composite membranes up to 3 wt% POSS loaded samples. An increase of about 76% in tensile strength and of strain at break 1.28% was achieved for 3 wt% POSS loaded nanocomposite membranes compared with chitosan membranes. The presence of POSS filler into polymer matrix increased the plasma protein adsorption on the surface. Maximum protein capacity and swelling was obtained for 10 wt% loaded samples. High cell viability results were obtained with indirect extraction of chitosan/POSS composites. Besides, cell proliferation and ALP activity results showed that POSS incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. This novel composite membranes with tunable properties could be considered as a potential candidate for guided bone regeneration applicationsBook Part Citation - Scopus: 1Mass Spectroscopy in Polymer Research(John Wiley and Sons Inc., 2012) Hacaloğlu, Jale; Yalçın, TalatMass spectrometers are currently available in numerous confi gurations with various ionization techniques and mass analyzers. For a specifi c polymer sample, an optimal choice should be done depending on the information sought. In practice, no single mass spectrometric technique can provide all necessary information for structural, compositional, and thermal and oxidative degradation characteristics of polymeric samples. The analyzer used determines the limits of the sensitivity and resolution and the mass range, whereas the type of ionization source specifi es the information that can be gained.Article Analyzing the Surface Properties of Acrylic-Based Water-Soluble Polymers(Taylor and Francis Ltd., 2017) Topaloğlu Yazıcı, Demet; Çetinkaya, Hayrullah; Şölener, Musa; Albayrak, AdileThe surface properties of newly synthesized N-methoxy isopropyl acrylamide, N-methoxy isopropyl methacrylamide, cyclo propyl acrylamide, and cyclo propyl methacrylamide polymers were investigated using inverse gas chromatography. The highest dispersive component of the surface energy value was obtained for cyclo propyl methacrylamide at 30°C. The values obtained for all polymers were decreasing with the increasing temperature. The values obtained for the acidic and the basic parameters revealed strong basic characters for the surface of N-methoxy isopropyl methacrylamide and cyclo propyl methacrylamide polymers and weak basic characters for the surface of N-methoxy isopropyl acrylamide and cyclo propyl acrylamide polymers.Article Citation - WoS: 14Citation - Scopus: 20Design of Polymeric Antiscalants Based on Functional Vinyl Monomers for (fe, Mg) Silicates(American Chemical Society, 2017) Topçu, Gökhan; Çelik, Aslı; Baba, Alper; Demir, Mustafa MuammerSilica/silicate scaling is one of a few detrimental problems that cause high economical loss in the geothermal and petroleum fields. The prevention of silica/silicate has been attempted using antiscalants with functional groups, particularly -NH2; however, metal silicates are commonly found in the fields, and the antiscalants developed thus far are not effective against these compounds. In this work, polymeric antiscalants have been developed by merging two or more functional comonomers consisting of various chelating groups for metal cations. Homo- and copolymers of acrylamide (AM), the sodium salt of vinyl sulfonic acid (VSA), and vinyl phosphonic acid (VPA) were synthesized to examine their antiscaling performance against metal silicate scaling. Lab-scale metal silicates were obtained in a pressured autoclave reactor. The antiscalants were tested at various dosages (25, 50, and 100 ppm), and their effects were investigated from the leftover decantates after isolation of the solid precipitates. The polymeric antiscalants were found to be particularly effective against metal silicates and ineffective against simple silica precipitates. Acidic groups may be coordinating the metal cations, which prevents the formation of precipitates. Among these acidic comonomers, VSA-containing polymers, in particular, increased the solubility of metal silicates.Article Citation - WoS: 15Citation - Scopus: 21Triboluminescent Electrospun Mats With Blue-Green Emission Under Mechanical Force(American Chemical Society, 2017) İncel, Anıl; Varlıklı, Canan; McMillen, Colin D.; Demir, Mustafa MuammerFibrous mechanosensing elements can provide information about the direction of crack propagation and the mechanism of material failure when they are homogeneously dispersed into the bulk volume of materials. A fabrication strategy of fibrous systems showing triboluminescent (TL) responses is in high demand for such applications. In this work, micrometer-sized Cu(NCS)(py)2(PPh3) crystals were synthesized, and polymeric fibrous mats containing the TL crystals were obtained via electrospinning as a stress probe for the determination of mechanical impact. Four different polymeric systems have been employed (PMMA, PS, PU, and PVDF), and the mechano-optical sensing performance of electrospun mats of the polymer-crystal composites was measured. Photophysical properties (quantum yield, band gap, and broadness of the emission) of the TL crystal/electrospun mat composites were also studied. TL and PL emission maxima of the PU-based composite mat show identical behavior due to the chemical affinity between the two structures and the smallest fiber diameter. Moreover, the PU fiber mats exhibit long-lived bluish-green emission persisting over a large number of drops.Article Citation - WoS: 24Citation - Scopus: 30Solution Electrospinning of Polypropylene-Based Fibers and Their Application in Catalysis(Korean Fiber Society, 2016) Berber, Emine; Horzum, Nesrin; Hazer, Bakí; Demir, Mustafa MuammerSince the dissolution of polyolefins is a chronic problem, melt processing has been tacitly accepted as an obligation. In this work, polypropylene (PP) was modified on molecular level incorporating poly(ethylene glycol) (PEG) as graft segment (PP-g-PEG) in a range of 6 to 9 mol%. Gold nanoparticles were nucleated in the presence of the copolymer chains via redox reaction. The dissolution of the amphiphilic comb-type graft copolymers containing gold nanoparticles (80 nm in diameter) was achieved in toluene and successfully electrospun from its solution. The diameter of composite fibers was in the range from 0.3 to 2.5 μm. The design of the structurally organized copolymer fiber mats provided a support medium for the nanoparticles enhancing the active surface area for the catalytic applications. The resulting composite fibers exhibited rapid catalytic reduction of methylene blue (MB) dye in the presence of sodium borohydride (NaBH4) compared to corresponding composite cast film.Article Citation - WoS: 14Citation - Scopus: 14Polythiophene Derivative on Quartz Resonators for Mirna Capture and Assay(Royal Society of Chemistry, 2015) Palaniappan, Al.; Cheema, Jamal Ahmed; Rajwar, Deepa; Ammanath, Gopal; Xiaohu, Liu; Seng Koon, Lim; Yi, Wang; Yıldız, Ümit Hakan; Liedberg, BoA novel approach for miRNA assay using a cationic polythiophene derivative, poly[3-(3′-N,N,N-triethylamino-1′-propyloxy)-4-methyl-2,5-thiophene hydrobromide] (PT), immobilized on a quartz resonator is proposed. The cationic PT enables capturing of all RNA sequences in the sample matrix via electrostatic interactions, resulting in the formation of PT-RNA duplex structures on quartz resonators. Biotinylated peptide nucleic acid (b-PNA) sequences are subsequently utilized for the RNA assay, upon monitoring the PT-RNA-b-PNA triplex formation. Signal amplification is achieved by anchoring avidin coated nanoparticles to b-PNA in order to yield responses at clinically relevant concentration regimes. Unlike conventional nucleic acid assay methodologies that usually quantify a specific sequence of RNA, the proposed approach enables the assay of any RNA sequence in the sample matrix upon hybridization with a PNA sequence complementary to the RNA of interest. As an illustration, successful detection of mir21, (a miRNA sequence associated with lung cancer) is demonstrated with a limit of detection of 400 pM. Furthermore, precise quantification of mir21 in plasma samples is demonstrated without requiring PCR and sophisticated instrumentation.