Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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Conference Object Redundancy resolution options for the twin-it-romans robotic hybrid manufacturing system(Springer Science and Business Media B.V., 2025) Gündüz, G.M.; Dede, Mehmet İsmet Can; Kiper, Gökhan; Schmitz, M.; Corves, B.The Twinnig Iztech in Robotics Manufacturing System (TWIN-IT-ROMANS) project funded by EU Horizon -Widera-2023-Access-02-01 aims to develop a hybrid manufacturing system that can perform additive and subtractive manufacturing processes and inline quality control using a robotic system. The system will incorporate a 6-degree-of-freedom robot arm and a positioner with 2-degree-of-freedom, which will operate synchronously. This manipulation system is to be designed for performing different manufacturing operations with different degrees-of-freedom requirements. In order to reveal alternative trajectory planning scenarios for this system, this paper presents an initial review of redundancy resolution approaches for kinematically redundant robotic manipulators. First, the four main approaches for redundancy resolution techniques are introduced. Then main studies on energy minimization and stiffness maximization for kinematically redundant robotic manipulators are reviewed. Similar or new approaches are planned to be generated and implemented for the redundant system for hybrid manufacturing. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.Article Can Fish Kills in Izmir Bay Be Explained With Satellite Image Analysis(Osman Orhan, 2025) Elçi, Sebnem; Erdem, Ahmet Adnan; Şekerci, HalilMotivated by a significant environmental crisis that emerged, where large numbers of dead fish washed ashore in İzmir Bay in the summer of 2024, this study aims to analyze the spatial and temporal dynamics of water quality in the inner bay prior to this incidence. By calculating indices such as NDCI, SABI, and UWQV, and correlating them with climatic data (air temperature, wind speed and relative humidity), this research seeks to document the occurrence and drivers of algal blooms in the bay using Landsat 8 and Sentinel-2 satellite data from 2017 to 2025. This is the first comprehensive study conducted for İzmir Bay that investigates the relationships between water quality indices and climatic variables. It also incorporates aerial analysis of the inner bay to provide a broader spatial perspective. A customized code using Python is developed for this study to independently download and analyze raw satellite data with respect to defined corrections/masks. The results of eight years of analysis indicated that critical conditions arise every summer with air temperatures reaching 40 degrees in the study area. Estimated aerial averaged NDCI index and Chl-a concentration values show a strong positive correlation with air temperature, particularly in the Spearman’s rank correlation (rs = 0.67 and 0.62 respectively), indicating a significant relationship between these parameters. Aerial distribution of the indices for the selected critical dates also revealed a significant increase in estimated Chl-a levels during the summer months, specifically in the regions determined from the risk maps produced as a result of this study. The areas with the greatest vulnerability coincide where Poligon, Ilıca streams in the south and Bostanlı and Çiğli streams in the north discharging into the bay. It is recommended that any planned external intervention methods for managing algal blooms should start with these highly vulnerable areas as presented by this study.Article Effect of Marination on the Formation of Polycyclic Aromatic Hydrocarbons in Grilled Vegetables(Wiley, 2025) Kacmaz Ozcetin, Sibel; Artok, LeventThe effect of marination on the formation of polycyclic aromatic hydrocarbons (PAH) in charcoal-grilled vegetables was studied. Various marinade ingredients, including apple cider vinegar, red grape vinegar, lemon juice, garlic powder, black pepper, and the food additive tert-butylhydroquinone (TBHQ) were applied to vegetable samples before charcoal grilling. The total phenolic content (TPC) and total antioxidant capacity (TAC) of each marinade ingredient were assessed for their contribution to PAH inhibition. A substantial decrease in PAH4 formation was observed in marinated vegetables. Red grape vinegar exhibited the strongest average inhibitory effect on total PAH4 formation (75%), followed by apple vinegar (68%), lemon juice (52%), garlic powder (34%), and black pepper (30%). Additionally, the TBHQ (67%) demonstrated a strong inhibitory effect, reducing total PAH4 formation by 67%. These findings offer valuable insights for reducing PAH levels in grilled vegetables and preventing their formation.Article Citation - WoS: 15Search for Supersymmetry in pp Collisions at √s=7 TeV in Events With a Single Lepton, Jets, and Missing Transverse Momentum(Springer, 2013) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, obtained with the CMS detector at the LHC. Three separate background estimation methods, each relying primarily on control samples in the data, are applied to a range of signal regions, providing complementary approaches for estimating the background yields. The observed yields are consistent with the predicted standard model backgrounds. The results are interpreted in terms of limits on the parameter space for the constrained minimal supersymmetric extension of the standard model, as well as on cross sections for simplified models, which provide a generic description of the production and decay of new particles in specific, topology based final states.Article Role of Long Non-Coding RNA X-Inactive Transcript (XIST) in Neuroinflammation and Myelination: Insights From Cerebral Organoids and Implications for Multiple Sclerosis(MDPI, 2025) Pepe, Nihan Aktas; Acar, Busra; Zararsiz, Gozde Erturk; Guner, Serife Ayaz; Sen, AlaattinBackground/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses within cerebral organoids in the context of Multiple Sclerosis (MS) pathogenesis. Methods: Human cerebral organoids with oligodendrocytes were produced from XIST-silenced H9 cells, and the mature organoids were subsequently treated with either FTY720 or DMF. Gene expression related to inflammation and myelination was subsequently analyzed via qRT-PCR. Immunofluorescence staining was used to assess the expression of proteins related to inflammation, myelination, and neuronal differentiation. Alpha-synuclein protein levels were also checked via ELISA. Finally, transcriptome analysis was conducted on the organoid samples. Results: XIST-silenced organoids presented a 2-fold increase in the expression of neuronal stem cells, excitatory neurons, microglia, and mature oligodendrocyte markers. In addition, XIST silencing increased IL-10 mRNA expression by 2-fold and MBP and PLP1 expression by 2.3- and 0.6-fold, respectively. Although XIST silencing tripled IBA1 protein expression, it did not affect organoid MBP expression. FTY720, but not DMF, distinguished MBP and IBA1 expression in XIST-silenced organoids. Furthermore, XIST silencing reduced the concentration of alpha-synuclein from 300 to 100 pg/mL, confirming its anti-inflammatory role. Transcriptomic and gene enrichment analyses revealed that the differentially expressed genes are involved in neural development and immune processes, suggesting the role of XIST in neuroinflammation. The silencing of XIST modified the expression of genes associated with inflammation, myelination, and neuronal growth in cerebral organoids, indicating a potential involvement in the pathogenesis of MS. Conclusions: XIST may contribute to the MS pathogenesis as well as neuroinflammatory diseases such as and Alzheimer's and Parkinson's diseases and may be a promising therapeutic target.Article Decision-Support Approaches for Sustainable Water Resource Management in Northwest Algeria(Polish Society of Ecological Engineering – PTIE, 2025) Meskine, Ahmed; Cherif, El Amine; Zerouali, Bilel; Ouadja, Abid; Santos, Celso Augusto Guimaraes; Bailek, Nadjem; Baba, AlperThis study investigates water resource management in the Wilaya of Mostaganem, northwest Algeria, using the water evaluation and planning (WEAP) decision support tool in combination with the analytic hierarchy process (AHP). As water scarcity becomes increasingly critical due to population growth, agricultural demands, and climate variability, effective management strategies are essential. This research employs WEAP to simulate various water demand and supply scenarios, assessing the impacts of irrigation efficiency, industrial development, and climate conditions on water availability. Under the ASI scenario, unsatisfied water demand may reach 4.3 hm3 per year by 2027. However, improving irrigation efficiency could reduce this by up to 50% compared to the reference scenario. Seasonal variations reveal deficits reaching 3.2 hm3 per month during the summer months of July through October. Additionally, the study highlights that a significant increase in water demand, exceeding 80 hm3 by 2060, can be mitigated through improved water supply initiatives, such as constructing new dams. The integration of AHP enables the prioritization of management strategies based on stakeholder preferences, demonstrating that adapting to climate change can stabilize demand below 50 million cubic meters. This integrated approach provides valuable insights for policymakers and stakeholders in developing sustainable water resource strategies that address the challenges faced by the Mostaganem region.Article Plasma Proteomic Markers of Interleukin-1β Pathway Associated With Incident Age-Related Macular Degeneration in Persons With Aids(Elsevier, 2025) Hunt, Peter W.; Olshen, Adam B.; Murad, Natalia; Ambayec, Gabrielle C.; Sezgin, Efe; Schneider, Michael F.; Jabs, Douglas A.Objective To evaluate the associations of plasma inflammatory proteins with age-related macular degeneration (AMD) in persons with the AIDS, using a discovery-based proteomics approach. Design A nested case-control study (analysis 1) and nested cohort study (analysis 2). Participants Persons with AIDS enrolled in the Longitudinal Study of the Ocular Complications with AIDS (LSOCA). Methods Cryopreserved plasma specimens obtained at baseline were assayed for inflammatory proteins using the Olink Inflammation Explore Panel 1. In analysis 1, baseline proteomic profiles for 26 persons with AIDS and incident intermediate-stage AMD 5 to 10 years after baseline and 49 matched controls (matched for age, biologic sex, race/ethnicity, and follow-up) without AMD were compared. In analysis 2, 475 persons from LSOCA with baseline plasma inflammatory proteomic profile measurements were followed for incident cataract and mortality. Main Outcome Measures Incident intermediate-stage AMD; incident cataract; and mortality. Results Of 365 measurable plasma inflammatory proteins, 118 (32%) were associated with incident intermediate-stage AMD at the false discovery rate-adjusted Q < 0.05 level after adjustment for smoking, CD4+ T count, and plasma human immunodeficiency virus RNA level. Gene ontology pathway enrichment analysis identified the interleukin (IL)-1 beta pathway and wound healing pathways, including tissue inhibitor of metalloproteinase 3, as significantly associated with incident AMD. These associations were qualitatively different from those associated with incident cataracts, where elevated levels of inflammatory proteins were associated with a decreased risk of cataracts. A much broader number of inflammatory pathways, including those related to the adaptive immune system, were associated with mortality. Conclusions Upregulation of the IL-1 beta pathway appears to be associated with an increased risk of incident AMD in persons with AIDS. Given the availability of inhibitors of this pathway, inhibition of the IL-1 beta pathway may provide a therapeutic avenue for treatment of AMD. Financial Disclosure(s) Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Ophthalmology Science 2025;5:100794 (c) 2025 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Article Demystifying Power and Performance Variations in Gpu Systems Through Microarchitectural Analysis(Comsis Consortium, 2025) Topcu, Burak; Karabacak, Deniz; Oz, IsilGraphics Processing Units (GPUs) serve efficient parallel execution for general-purpose computations at high-performance computing and embedded systems. While performance concerns guide the main optimization efforts, power issues become significant for energy-efficient and sustainable GPU executions. Profilers and simulators report statistics about the target execution; however, they either present only performance metrics in a coarse kernel function level or lack visualization support that can enable microarchitectural performance analysis or performance-power consumption comparison. Evaluating runtime performance and power consumption dynamically across GPU components enables a comprehensive tradeoff analysis for GPU architects and software developers. In this work, we present a novel memory performance and power monitoring tool for GPU programs, GPPRMon, which performs a systematic metric collection and provides useful visualization views to guide power and performance analysis for target executions. Our simulation-based framework dynamically gathers SM and memory-related microarchitectural metrics by monitoring individual instructions and reports dynamic performance and power values. Our interface presents spatial and temporal views of the execution. While the first demonstrates the performance and power metrics across GPU memory components, the latter shows the corresponding information at the instruction granularity in a timeline. We demonstrate performance and power analysis for memory-bound graph applications and resource-critical embedded programs from GPU benchmark suites. Our case studies reveal potential usages of our tool in memory-bound kernel identification, performance bottleneck analysis of a memory-intensive workload, performance-power evaluation of an embedded application, and the impact of input size on the memory structures of an embedded system.Article 21st Century Urban Aesthetics in the Post Critical Age: Sanart Publication(Istanbul Teknik Universitesi, Faculty of Architecture, 2025) Kök, S.; Akpinar, İ.This research problematized the relationship between human and the built environment in the 21st century, which it describes as post-critical, and examined the relationship between them in a theoretical framework through aesthetics. Within this framework, it has analyzed selected articles from the proceedings book published by SANART (Association of Aesthetics and Visual Arts). This study has defined aesthetics as a way of relating human beings to their environment. It redefined holistic aesthetic thought through approaches that focus on uncertain, porous, relational boundaries and social processes. With new perspectives that reject the dualism of subject and object, the process associated with the concepts of movement and becoming have been conceptualized through the process of urban experience from the perspective of Manuel DeLanda. This study has analyzed the urban discourses presented in SANART publications with a focus on ’movement’. It has interpreted these movements as a feature of the built environment as it is shaped by the capacities of bodies and space. It has argued that a movementoriented evaluation of urban aesthetics would further the development of the critical field. © 2025, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.Article Citation - WoS: 8Citation - Scopus: 8A Review of the Experimental and Numerical Studies on the Compression Behavior of the Additively Produced Metallic Lattice Structures at High and Low Strain Rates(KeAi Communications Co., 2025) Bin Riaz, Muhammad Arslan; Guden, MustafaRecent advances in additive manufacturing have enabled the construction of metallic lattice structures with tailored mechanical and functional properties. One potential application of metallic lattice structures is in the impact load mitigation where an external kinetic energy is absorbed by the deformation/ crushing of lattice cells. This has motivated a growing number of experimental and numerical studies, recently, on the crushing behavior of additively produced lattice structures. The present study overviews the dynamic and quasi-static crushing behavior of additively produced Ti64, 316L, and AlSiMg alloy lattice structures. The first part of the study summarizes the main features of two most commonly used additive processing techniques for lattice structures, namely selective-laser-melt (SLM) and electrobeam-melt (EBM), along with a description of commonly observed process induced defects. In the second part, the deformation and strain rate sensitivities of the selected alloy lattices are outlined together with the most widely used dynamic test methods, followed by a part on the observed microstructures of the SLM and EBM-processed Ti64, 316L and AlSiMg alloys. Finally, the experimental and numerical studies on the quasi-static and dynamic compression behavior of the additively processed Ti6 4, 316L, and AlSiMg alloy lattices are reviewed. The results of the experimental and numerical studies of the dynamic properties of various types of lattices, including graded, non-uniform strut size, hollow, non-uniform cell size, and bio-inspired, were tabulated together with the used dynamic testing methods. The dynamic tests have been noted to be mostly conducted in compression Split Hopkinson Pressure Bar (SHPB) or Taylor-and direct-impact tests using the SHPB set-up, in all of which relatively small-size test specimens were tested. The test specimen size effect on the compression behavior of the lattices was further emphasized. It has also been shown that the lattices of Ti6 4 and AlSiMg alloys are relatively brittle as compared with the lattices of 316L alloy. Finally, the challenges associated with modelling lattice structures were explained and the micro tension tests and multi-scale modeling techniques combining microstructural characteristics with macroscopic lattice dynamics were recommended to improve the accuracy of the numerical simulations of the dynamic compression deformations of metallic lattice structures. (c) 2025 China Ordnance Society. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).