Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Department: search.filters.department.İzmir Institute of TechnologySubject: search.filters.subject.Lithium

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  • Article
    Sustainable Recovery of Critical Raw Materials From Geothermal Igneous Systems: Geochemical, Mineralogical, and Techno-Economic Insights from the Dikili-Bergama Field (Western Anatolia, Turkiye)
    (Elsevier, 2026) Ayzit, Tolga; Baba, Alper
    The sustainable co-extraction of critical raw materials (CRMs) with renewable geothermal energy offers a dual pathway to support the circular economy and low-carbon transition. In this study, an integrated geochemical and mineralogical approach is used to comprehensively assess the recoverable lithium (Li) boron (B), strontium (Sr) and other critical raw materials in the geothermal reservoirs of the Dikili-Bergama region Turkiye. A geochemical analysis was carried out by systematic sampling and multi-element testing of geothermal water and reservoir rock. Hydrogeochemical studies of the geothermal fluids indicated the presence of remarkable concentrations of B (4.6 ppm), Sr (2.8 ppm) and Li (1.2 ppm), suggesting the possibility of active leaching processes in the deposit. Mineralogical studies using X-ray diffraction (XRD) have revealed a number of secondary mineral phases, such as quartz and labradorite, indicating the interaction between water and rock. These interactions affect not only the permeability and porosity of the deposit, but also the mobilization and precipitation of CRMs. A techno-economic analysis will be used to identify potential synergies that could improve the economic feasibility of geothermal projects in the region. The Monte Carlo simulation has shown that the Dikili-Bergama geothermal reservoirs have a potential of similar to 712 tons of Li. In this study, the CRM potential that emerged during the geothermal energy exploitation process in the region was calculated. The temporality and the process of obtaining are completely related to the extraction technology. This offers the dual benefit of renewable energy and strategic mineral extraction, contributing to sustainable resource management in volcanic environments.
  • Article
    Mass Spectrometric Profiling Reveals Alterations in N-Glycans and O-Glycans in Tay-Sachs Disease Under Autophagy-Induced Conditions
    (Springer, 2025) Can, Melike; Basirli, Hande; Jin, Chunsheng; Karlsson, Niclas G.; Bojar, Daniel; Seyrantepe, Volkan
    Tay-Sachs disease is a rare neurodegenerative disorder caused by mutations in the HEXA gene. The HEXA gene encodes the alpha-subunit of the enzyme beta-hexosaminidase A, which degrades GM2 ganglioside. Previously, we identified impaired autophagy in the brains of a mouse model of Tay-Sachs disease, which exhibited neuropathological and clinical abnormalities. Moreover, we demonstrated autophagosome clearance in Tay-Sachs cells under lithium-induced conditions. Here, we further aimed to evaluate N- and O-glycan changes in these cells and examine whether glycan alterations are linked to ER stress. The profiles of N- and O-glycans were analyzed using LC-MS/MS in fibroblasts and neuroglial cells from 5-month-old Hexa-/-Neu3-/- mice and neuroglial cells from Tay-Sachs patients under lithium induction and nutrient deprivation. The expression levels of ER stress-related markers were assessed using qRT-PCR and Western blot analyses. We demonstrated higher levels of high mannose and lower levels of complex types of N-glycans, along with increased O-glycan levels in Tay-Sachs cells. Compared to control groups, we observed upregulated expression of endoplasmic reticulum (ER) stress-related markers, CHOP and ATF-6, in Tay-Sachs cells. Our study demonstrated that autophagy induction causes the degradation of accumulated high-mannose N-glycans and O-glycans, which is associated with the downregulation of ER stress-related genes in Tay-Sachs cells. Our study is the first to show this phenomenon in Tay-Sachs cells and suggests the presence of ER stress-mediated autophagy. Therefore, targeting glycans through autophagy induction could offer therapeutic benefits to patients with Tay-Sachs disease in future studies.