Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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  • Article
    Valorization of Recycled Waste in Green/White Purification and LC-QTOF/MS Analysis of Beverages Adulterated with Incapacitating Drugs
    (Elsevier B.V., 2026) Anilanmert, Beril; Yonar, Fatma Cavus; Er, Elif Ozturk; Pekcaliskan, Elif Yılmaz; Cengiz, Salih
    Incapacitating drugs constitute a growing threat for the community, since victims may drink adulterated beverages without noticing. A validated eco-friendly/economical purification/analysis kit prototype, along with an LC-QToF/MS method has been developed in coke and mixed fruit-juice, for simultaneous determination of 10 drugs used for incapacitating victims (zaleplone, zolpidem, zopiclone, mephedrone, fentanyl, phenytoin, thiopental, sertraline, ketamine and GHB). A combination of two different waste nut-shells which yielded the highest recovery for these drugs were directly used as adsorbent after grinding and modification and a reusable separation apparatus recycled from waste were utilized for the first time in a toxicological analysis. In the method, after adding the adsorbent on to the sample, pH was adjusted. Following 25-min (min) automatic vortexing for adsorption, matrix was removed easily, using the separation apparatus. After 25-min desorption via cold ultrasonication using 500 μL methanol, a 9.5-min LC-QToF/MS analysis was performed. The validated method in fruit-juice and coke, extraordinarily gave successful results also in urine and saliva. Assessment tools for greenness/whiteness and pictograms confirmed the environmental friendliness of the method kit. © 2025 Elsevier B.V.
  • Article
    Reduced Phase Space Quantization and Quantum Corrected Entropy of Schwarzschild-De Sitter Horizons
    (Elsevier B.V., 2026) Jalalzadeh, S.; Moradpour, H.
    This paper investigates the quantization of the Schwarzschild–de Sitter (SdS) black hole (BH) using the Misner–Sharp–Hernandez (MSH) mass as the internal energy in a reduced phase space framework. After introducing the canonical variables of the reduced phase space, we derive a discrete spectrum for the surface areas of the BH event horizon (EH) as well as MSH masses. We utilized the MSH mass spectrum to obtain the entropy of the BH. The entropy of the BH and cosmic EHs reveals a logarithmic correction to the Bekenstein–Hawking term. Our results support the robustness of the logarithmic form of quantum corrections in SdS thermodynamics. © 2026 The Authors.
  • Article
    Polyaspartic Ester Polyurea-TiO2nanocomposite Coatings for UV Protection of Leading Edge of Wind Turbine Blades
    (Elsevier B.V., 2026) Olcer, Y.A.; Karabacak, B.D.; Demirkurt, M.; Yoldaş, İ.; Can y, Z.; Demir, M.
    Polyaspartic ester polyurea (PAEPU) supplies a promising matrix for high-durability coatings. However, its poor UV-A resistance make its usage limited. In this work, commercially available anatase TiO<inf>2</inf> particles (0.05–10 wt%) were dispersed in PAE matrix without any modification. PAEPU/TiO<inf>2</inf> composites were supplied by the reaction of PAE/TiO<inf>2</inf> matrix with an aliphatic isocyanate. UV–Visible spectra of spin coated PAEPU/TiO<inf>2</inf> composite thin films showed an exponential decrease in transmittance with increasing amount of TiO<inf>2.</inf> The optical response is dominated by UV blocking for TiO<inf>2</inf> amounts smaller than 0.3 wt%. For above 0.5 wt% TiO<inf>2</inf> amounts, transparency to translucency transition signifies the beginning of multiple scattering. The diameter of particles analyzed by AFM showed that particle diameter is 47 ± 11 nm taking into account of images of the PAEPU films containing 0.3 wt% of TiO<inf>2</inf> particles. Radial distribution function of the particle domains achieved from microscopy suggests that interparticle distance gets smaller than the wavelength of the incident light even at low the particle concentration. Accelerated weathering test were performed by applying 0.1, 0.5, 1.0, and 3.0 wt% TiO<inf>2</inf> containing PAEPU composite films on a white primer with Doctor Blade method. 0.1 wt% PAEPU/TiO<inf>2</inf> composites shows lower ΔE value compare to both neat and higher amounts of TiO<inf>2</inf> containing PAEPU composite films. The results suggest that without the complexity and cost of the surface modification, the low loading of commercial TiO<inf>2</inf> into PAE matrix may supply UV-stabilized PAEPU coatings relevant to the leading-edge protection of wind-turbine blades. © 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
  • Article
    A Simplified Molecular Imprinting Strategy Through Electrospinning of Polyacrylonitrile for Thin Film Microextraction of Selected Pesticides
    (Elsevier B.V., 2026) Şahin, A.; Akpinar, Y.; Yildirim, E.; Eroǧlu, A.E.; Boyaci, E.
    Molecularly imprinted polymers (MIPs) have been extensively used as selective extractive phases for sample preparation because of their analyte-selective binding sites. However, MIP preparation requires optimized monomer-template interactions and long polymerization reactions. In this study, a novel and simple method of MIP preparation was proposed based on electrospinning. Instead of preparing analyte-monomer complexes before polymerization, model analytes (trifluralin and carbaryl) were directly dissolved in a polyacrylonitrile (PAN) solution, then electrospun into nanofibrous mats. This allowed for a means of preparation of highly crystalline, template-imprinted nanostructures with minimal synthetic complexity. Following the characterization studies for the new material, the extraction properties of the imprinted and nonimprinted electrospun mats were investigated in thin film microextraction (TFME) studies by extracting trifluralin and carbaryl from water samples, followed by gas chromatography-mass spectrometry (GC–MS) analysis. The optimization results showed that samplers containing 10.0 mg of MIP sorbents made by electrospinning of a solution containing 5.0 mg of template in 1.0 mL of PAN solution resulted in approximately 4 and 7 times enhanced extraction recoveries for carbaryl and trifluralin compared to samplers made of non-imprinted bulk PAN. Moreover, the cross-reactivity testing performed with non-template analytes (malathion and diazinon) suggested a more specific extraction towards trifluralin compared to carbaryl. The proposed new technique was also validated using computational methodology, which supported the experimental finding about higher selectivity towards trifluralin. This may signify a probability for structural orientation of partially charged trifluralin under an electrical field in electrospun PAN creating favorable extraction sites. © 2025 Elsevier B.V.
  • Conference Object
    Microarc: Event Driven Analysis and Design Method for Microservices
    (Elsevier B.V., 2025) Yıldız, Ali; Demirors, Onur
    The rapid development of the Internet infrastructure has enabled software applications to leverage almost unlimited and scalable resources. Microservice-based architecture has emerged as a solution to harness the benefits of a distributed cloud-based infrastructure. Event-driven architecture is a powerful approach for addressing challenges in distributed systems, such as scalability, distributed data, and sharing of data at scale. In an event-driven microservice architecture, decoupled services interact by responding to events and event streams facilitate data sharing between them. Despite these advantages, there is no de facto method for the analysis and design of systems within microservice architecture. Organizations often face difficulties in developing microservice-based systems, owing to the lack of well-defined methodologies for analysis and design. In this study, we present an analysis and design method for microservice-based systems. MicroArc is a method for analyzing and designing microservice-based systems, and comprises modeling notations, guiding processes to articulate how the method is applied, and a supporting tool for modelling. The MicroArc approach enables the identification of events and microservice candidates by modeling the flow of processes in the early phase of development. © 2025 Elsevier B.V., All rights reserved.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 1
    Porous Polymer-Derived Ceramics for Environmental Applications: Sorption, Filtration, and Catalysis
    (Elsevier B.V., 2025) Icin, Oyku; Zeydanli, Damla; Biesuz, Mattia; Soraru, Gian Domenico; Vakifahmetoglu, Cekdar
    Polymer-derived ceramics (PDCs), obtained from preceramic polymers, have emerged as promising materials for environmental applications due to their high thermal and chemical stability, tunable nano-microstrucure and porosity, and versatile surface functionalities. This review focuses on the recent advances in porous PDCs and their use in key environmental fields such as sorption, filtration, and catalysis. A comparative analysis of precursor chemistry, synthesis strategies, and resulting structural properties is presented, emphasizing how these factors influence performance in environmental remediation tasks. By consolidating findings across specific application areas, the work aims to clarify the functional potential of PDCs and identify current research gaps and opportunities for future development in environmental material science.
  • Conference Object
    Dynamic Recognition of the Nucleosome Core Particle by Select Chromatin Factors
    (Elsevier B.V., 2025) Döseme, H.; Uluçay, T.; Kale, S.
    The intricate interactions between the nucleosome core particle and chromatin-binding proteins control essential biological functions templated by DNA. The nucleosome is a symmetrical and disc-shaped nucleoprotein which binds several chromatin factors in a 2:1 stoichiometry. We report computational evidence for a DNA-sequence-driven emergence of asymmetry whereby the nucleosome binding affinities of the chromatin factors are altered on each side even though the protein factors bind chemically equivalent proteinous interfaces of the nucleosome. Furthermore, none of these proteins interact directly with the nucleosomal DNA. Using atomistic molecular dynamics simulations, we surveyed five chromatin factors that are known to bind the nucleosome in a 2:1 stoichiometry. In four factors, we found that the nucleosomal gyre that binds DNA strongly is also more preferred. These factors are Sir3, PRC1, RCC1, and SAGA-DUB. However, a fifth chromatin factor, 53BP1, prefers the gyre with the weaker DNA binding with higher affinity. We argue that this tunability in nucleosome affinity could be related to the function of the chromatin interactors as 53BP1 could prefer loose DNA gyres to execute its DNA repair function. © 2025 The Authors. Published by Elsevier B.V.
  • Article
    Recent Developments in the Treatment of Leishmaniasis: Natural Compounds, Drug Targets, in Silico Molecular Docking Approaches, and Nanocarriers
    (Elsevier B.V., 2025) Gürbüz Çolak, N.
    Leishmaniasis is a common tropical disease caused by Leishmania protozoa. It affects 0.9 to 1.6 million people, causing 20,000–30,000 deaths annually. There are no effective vaccines, and current treatments have severe side effects. Drug resistance is a major obstacle in treating leishmaniasis. The necessity of drug discovery is indisputable. Natural compounds are promising candidates for drug discovery studies because of their diverse chemical structures and bioactivities. Experimental screening of compound libraries imposes high costs and is time-consuming. The molecular docking approach is beneficial for exploring new therapeutics in silico as it allows the screening of millions of drug candidates. Even if new drug candidates are discovered, delivery of the active ingredient to the target remains controversial. Nanocarriers are promising nanosystems that can address the drawbacks of drug delivery. This chapter focuses on natural compounds as drug candidates, targets, in silico drug discovery, and drug delivery for the treatment of leishmaniasis. © 2025 Elsevier Inc.
  • Conference Object
    Localizing Implicit Gradient Damage Based Modelling of Quasi-Brittle Failure With Non-Planar Crack
    (Elsevier B.V., 2024) Kaçmaz,B.; Ozdemir,I.
    Localizing implicit gradient damage (LIGD) is a gradient extended model which is equipped with a decreasing internal length scale with damage evolution, Poh and Sun (2017). The model is thermodynamically consistent and resolves the well-known problems of conventional implicit gradient damage (CIGD) model such as artificial diffusion of damage and erroneous predictions of failure initiation and propagation directions. So far, the effectiveness of the model has been demonstrated for two-dimensional quasi-brittle and three-dimensional ductile failure predictions with flat fracture surfaces. It is the aim of this contribution to assess the predictive capabilities of the model for three-dimensional quasi-brittle failures with non-planar cracks. To this end, localizing implicit gradient model is embedded within a tetrahedral element formulation and implemented in commercial finite element package Abaqus through user element (UEL) subroutine. Skew notched prismatic torsion test is modeled and capabilities of the model are assessed in terms of reaction force-displacement curves as well as the resulting crack surfaces, Brokenshire (1996), Jefferson et al. (2004). Comparison of LIGD and CIGD predictions suggest that LIGD is superior to CIGD. Furthermore, as far as capturing the experimental results is concerned, it performs as good as other alternative modeling frameworks, e.g., mixed finite element formulations. © 2024 The Author(s).
  • Conference Object
    Citation - Scopus: 3
    Localizing Implicit Gradient Damage Based Treatment of Softening in Elasto-Plasticity
    (Elsevier B.V., 2021) Yasayanlar,S.; Kaçmaz,B.; Özdemir,I.
    As opposed to brittle fracture, the failure of ductile materials is preceded by severe plastic deformations. Microscopic mechanisms i.e., void growth and coalescence result in macroscopic property degradation causing softening, localization, and finally macroscopic crack. This contribution focuses on softening in elasto-plasticity and its mesh-objective description using an implicit gradient type of non-local damage mechanics framework. As reported in several studies Geers et al. (1998), Poh and Sun (2017), artificial widening of localization zone is observed when conventional implicit gradient type regularization is used. To circumvent this non-physical artifact, localizing implicit gradient damage (LIGD) formulation that is motivated by higher order continuum arguments, is adopted, Poh and Sun (2017). As opposed to previous remedies to artificial widening of the localization zone, LIGD proposes an internal length scale that decreases with deformation. A two-field (displacement-non-local equivalent plastic strain) hexahedra and a three-field (displacement-pressure-non-local equivalent plastic strain) tetrahedra element are formulated and implemented in commercial finite element software Abaqus through user element (UEL) subroutine. The effectiveness of the approach is demonstrated by solving two numerical examples. © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of IWPDF 2021 Chair, Tuncay Yalçinkaya