Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
Browse
73 results
Search Results
Now showing 1 - 10 of 73
Review Citation - Scopus: 2Wnt/β-catenin Signaling in Central Nervous System Regeneration(2025) Nazli, D.; Bora, U.; Ozhan, G.The Wnt/β-catenin signaling pathway plays a pivotal role in the development, maintenance, and repair of the central nervous system (CNS). This chapter explores the diverse functions of Wnt/β-catenin signaling, from its critical involvement in embryonic CNS development to its reparative and plasticity-inducing roles in response to CNS injury. We discuss how Wnt/β-catenin signaling influences various CNS cell types-astrocytes, microglia, neurons, and oligodendrocytes-each contributing to repair and plasticity after injury. The chapter also addresses the pathway's involvement in CNS disorders such as Alzheimer's and Parkinson's diseases, psychiatric disorders, and traumatic brain injury (TBI), highlighting potential Wnt-based therapeutic approaches. Lastly, zebrafish are presented as a promising model organism for studying CNS regeneration and neurodegenerative diseases, offering insights into future research and therapeutic development. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.Review Citation - Scopus: 5A Comparative Evaluation of Dark Fermentative Bioreactor Configurations for Enhanced Hydrogen Production(Springer, 2025) Gören, Ayşegül Yağmur; Dincer, I.; Khalvati, A.Energy from renewable resources has been growing in popularity, which ultimately helps reduce emissions of greenhouse gases (GHGs) and contaminants. Since hydrogen (H2) has a higher combustion production of energy than hydrocarbon fuels, it has been identified as a clean, sustainable, and environmentally friendly energy source. There are several benefits to producing biohydrogen (bioH2) from renewable sources, including lower cost and increased sustainability. Among the bioH2 production processes, dark fermentation supports commercialization and scale-up for industrial applications. This paper considers the various bioreactors, such as anaerobic sequencing batch, continuous stirred, up-flow, fixed-bed, and membrane reactors, and their operational approaches for bioH2 production. This review paper also performs the bibliometric analysis method to identify historical and current developments in a particular field of reactor configuration studies. Furthermore, the main variables influencing reactor performance and methods for increasing process efficiency considering economic and environmental aspects are addressed. The results revealed that continuously stirred reactors are widely utilized for bioH2 production as a cost-effective reactor configuration. Moreover, the membrane bioreactors and fixed-bed reactors are yielded higher bioH2 performance than other configurations. Nevertheless, high energy consumption and costs have presented the need for further development of reactors. Consequently, future recommendations to solve the critical problems faced in reactor configurations, the gaps in the literature, and the points that need improvement were comprehensively reported. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.Review Mesenchymal Stem Cells in Cancer Therapy(2025) Baran, Z.; Çetinkaya, M.; Baran, Y.The mesenchymal stem/stromal cells (MSCs) are multipotent cells that were initially discovered in the bone marrow in the late 1960s but have so far been discovered in almost all tissues of the body. The multipotent property of MSCs enables them to differentiate into various cell types and lineages, such as adipocytes, chondrocytes, and osteocytes. The immunomodulation capacity and tumor-targeting features of MSCs made their use crucial for cell-based therapies in cancer treatment, yet limited advancement could be observed in translational medicine prospects due to the need for more information regarding the controversial roles of MSCs in crosstalk tumors. In this review, we discuss the therapeutic potential of MSCs, the controversial roles played by MSCs in cancer progression, and the anticancer therapeutic strategies that are in association with MSCs. Finally, the clinical trials designed for the direct use of MSCs for cancer therapy or for their use in decreasing the side effects of other cancer therapies are also mentioned in this review to evaluate the current status of MSC-based cancer therapies. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.Review Citation - WoS: 1Citation - Scopus: 2Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling(Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, ErdalOrgans-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.Review Citation - WoS: 4Citation - Scopus: 7Optimizing Lighting Design in Educational Settings for Enhanced Cognitive Performance: a Literature Review(Elsevier Science Sa, 2025) Celik, Meric; Didikoglu, Altug; Kazanasmaz, TugceLighting has more functions than simply illuminating spaces. For humans, light is the main signal that aligns our body's internal clock, regulating circadian rhythms. This process instructs our bodies to wake up in the morning, become alert during the day, and feel sleepy at night. Disruption of these rhythms can impact neurological and psychiatric health, including cognitive performance. We can utilize light for mood improvements and better cognitive performance to create a suitable learning environment for students in educational buildings. These non-visual effects of light need to be considered from the beginning of the design process, making an interdisciplinary effort necessary. Even with adequate light and dark, the human eye reacts differently under various conditions, influenced by light's photometric and colorimetric properties. While natural sunlight is ideal for aligning with our biological clock, it is not always sufficient, making artificial lighting essential indoors. LED technology offers promising solutions, catering to our non-visual needs in the absence of natural light and providing energy efficiency. This study reviews the literature that includes students' cognitive performance and well-being, energy efficiency, running costs, and environment-related issues such as light pollution. It aims to explore the impact of lighting design in learning environments.Review Citation - WoS: 26Citation - Scopus: 28Exploring Geothermal Energy Based Systems: Review From Basics To Smart Systems(Pergamon-elsevier Science Ltd, 2025) Anya, Belka; Mohammadpourfard, Mousa; Akkurt, Gulden Gokcen; Mohammadi-Ivatloo, BehnamMost of the energy demand is currently supplied from fossil fuels, which leads to the accumulation of greenhouse gases and air pollution. A sustainable future can be created globally through the efficient use of renewable energy sources. These sources include wind, solar, geothermal, biomass, and more. Geothermal energy can meet the energy needs of the future as a clean and reliable source and stands out due to certain distinctive features among renewable energy sources. Unlike other renewable energy sources, geothermal energy is not dependent on time or weather, making it a reliable and continuous energy supply. Additionally, it has a lower environmental impact. This review examines the development of geothermal energy systems and their integration into smart technologies, highlighting the potential of geothermal energy for smart energy systems. The focus is on integrating smart systems into geothermal-based setups to enhance efficiency and analyze the state-of-the-art technologies of such systems. Geothermal-based systems can be classified as single generation, co-generation, multigeneration, smart energy systems, and energy hubs. Consequent to examining systems, it has been concluded that geothermal systems have a huge potential, but unfortunately, not all of them are used due to some difficulties. Its development will occur faster, and its share in the renewable energy sector will grow with smart system integration.Review Citation - WoS: 1Citation - Scopus: 1Colloidal Quantum Dots as Solution-Based Nanomaterials for Infrared Technologies(Iop Publishing Ltd, 2024) Sevim Ünlütürk, S.; Taşcıoğlu, D.; Özçelik, S.This review focuses on recent progress of wet-chemistry-based synthesis methods for infrared (IR) colloidal quantum dots (CQD), semiconductor nanocrystals with a narrow energy bandgap that absorbs and/or emits IR photos covering from 0.7 to 25 micrometers. The sections of the review are colloidal synthesis, precursor reactivity, cation exchange, doping and de-doping, surface passivation and ligand exchange, intraband transitions, quenching and purification, and future directions. The colloidal synthesis section is organized based on precursors employed: toxic substances as mercury- and lead-based metals and non-toxic substances as indium- and silver-based metal precursors. CQDs are prepared by wet-chemical methods that offer advantages such as precise spectral tunability by adjusting particle size or particle composition, easy fabrication and integration of solution-based CQDs (as inks) with complementary metal-oxide-semiconductors, reduced cost of material manufacturing, and good performances of IR CQD-made optoelectronic devices for non-military applications. These advantages may allow facile and materials' cost-reduced device fabrications that make CQD based IR technologies accessible compared to optoelectronic devices utilizing epitaxially grown semiconductors. However, precursor libraries should be advanced to improve colloidal IR quantum dot synthesis, enabling CQD based IR technologies available to consumer electronics. As the attention of academia and industry to CQDs continue to proliferate, the progress of precursor chemistry for IR CQDs could be rapid. © 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.Review Citation - WoS: 13Citation - Scopus: 18Review of Cell Level Battery (calendar and Cycling) Aging Models: Electric Vehicles(Mdpi, 2024) Yarimca, Gulsah; Cetkin, ErdalElectrochemical battery cells have been a focus of attention due to their numerous advantages in distinct applications recently, such as electric vehicles. A limiting factor for adaptation by the industry is related to the aging of batteries over time. Characteristics of battery aging vary depending on many factors such as battery type, electrochemical reactions, and operation conditions. Aging could be considered in two sections according to its type: calendar and cycling. We examine the stress factors affecting these two types of aging in detail under subheadings and review the battery aging literature with a comprehensive approach. This article presents a review of empirical and semi-empirical modeling techniques and aging studies, focusing on the trends observed between different studies and highlighting the limitations and challenges of the various models.Review Citation - WoS: 41Citation - Scopus: 43Electrochemical Sensors in the Food Sector: a Review(American Chemical Society, 2024) Ghaani, Masoud; Azimzadeh, Mostafa; Büyüktaş, Duygu; Carullo, Daniele; Farris, StefanoIn a world that is becoming increasingly concerned with health, safety, and the sustainability of food supply chains, the control and assurance of food quality have become of utmost importance. This review examines the application and potential of electrochemical sensors in the dynamic field of food science to meet these expanding demands. The article introduces electrochemical sensors and describes their operational mechanics and the components contributing to their function. A summary of the most prevalent electrochemical methods outlines the diverse food analysis techniques available. The review shifts to discussing the food science applications of these sensors, highlighting their crucial role in detecting compounds in food samples like meat, fish, juice, and milk for contemporary quality control. This paper showcases electrochemical sensors' utility in food analysis, underscoring their significance as powerful, efficient tools for maintaining food safety and how they could transform our approach to global food quality control and assurance.Review Citation - WoS: 1Citation - Scopus: 2Bergamot (<i>citrus Bergamia</I>), a (poly)phenol-Rich Source for Improving Osteosarcopenic Obesity: a Systematic Review(Mdpi, 2024) Mazzola, Giuseppe; Rondanelli, Mariangela; Baron, Giovanna; Zupo, Roberta; Castellana, Fabio; Clodoveo, Maria Lisa; Perna, SimoneThis systematic review investigates the potential of bergamot, a polyphenol-rich citrus fruit, in improving osteosarcopenic obesity, a condition characterized by the simultaneous presence of osteoporosis, obesity, and sarcopenia. Bergamot extracts have been suggested to possess several pharmacological properties, including anti-inflammatory and antioxidant effects, which could be useful in the management of age-related diseases and neuromuscular health. The review highlights the promising effects of bergamot extracts on skeletal muscle mass and function, particularly in the context of obesity, metabolic syndrome, osteosarcopenic obesity, and osteoporosis. Furthermore, some studies have shown that bergamot extracts can improve the metabolic balance, endothelial function, and maximal oxygen uptake in athletes, highlighting their potential benefits for skeletal muscle health. Taken together, these results suggest that bergamot extracts, especially those rich in polyphenols, may be a valuable adjunct in the management of osteosarcopenic obesity and other associated clinical conditions involving pro-inflammatory effects on organs and tissues.