Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Citation - WoS: 65
    Citation - Scopus: 72
    Effect of Peg Grafting Density and Hydrodynamic Volume on Gold Nanoparticle-Cell Interactions: an Investigation on Cell Cycle, Apoptosis, and Dna Damage
    (American Chemical Society, 2016) Uz, Metin; Bulmuş, Volga; Alsoy Altınkaya, Sacide
    In this study, interactions of polyethylene glycol (PEG)-coated gold nanoparticles (AuNPs) with cells were investigated with particular focus on the relationship between the PEG layer properties (conformation, grafting density, and hydrodynamic volume) and cell cycle arrest, apoptosis, and DNA damage. Steric hindrance and PEG hydrodynamic volume controlled the protein adsorption, whereas the AuNP core size and PEG hydrodynamic volume were primary factors for cell uptake and viability. At all PEG grafting densities, the particles caused significant cell cycle arrest and DNA damage against CaCo2 and PC3 cells without apoptosis. However, at a particular PEG grafting density (∼0.65 chains/nm2), none of these severe damages were observed on 3T3 cells indicating discriminating behavior of the healthy (3T3) and cancer (PC3 and CaCo2) cells. It was concluded that the PEG grafting density and hydrodynamic volume, tuned with the PEG concentration and AuNP size, played an important role in particle-cell interactions.
  • Article
    Citation - WoS: 24
    Citation - Scopus: 24
    A Ratiometric Fluorescent Probe for Gold and Mercury Ions
    (John Wiley and Sons Inc., 2015) Üçüncü, Muhammed; Karakuş, Erman; Emrullahoğlu, Mustafa
    A fluorescent probe that displays a ratiometric fluorescence response towards gold and mercury ions has been devised. Emitting at a relatively longer wavelength, the conjugated form of the fluorescent dye transforms in the presence of the gold or mercury ions into a new dye, the molecular structure of which lacks the conjugation and consequently emits at a distinctly shorter wavelength. A fluorescent probe that displays a ratiometric fluorescence response towards gold and mercury ions has been devised. Emitting at a relatively longer wavelength, the conjugated form of the fluorescent dye transforms in the presence of the gold or mercury ions into a new dye (see figure).
  • Article
    Citation - WoS: 76
    Citation - Scopus: 79
    Near-Surface Viscosity Effects on Capillary Rise of Water in Nanotubes
    (American Physical Society, 2015) Vo, Truong Quoc; Barışık, Murat; Kim, BoHung
    In this paper, we present an approach for predicting nanoscale capillary imbibitions using the Lucas-Washburn (LW) theory. Molecular dynamics (MD) simulations were employed to investigate the effects of surface forces on the viscosity of liquid water. This provides an update to the modified LW equation that considered only a nanoscale slip length. An initial water nanodroplet study was performed to properly elucidate the wetting behavior of copper and gold surfaces. Intermolecular interaction strengths between water and corresponding solid surfaces were determined by matching the contact angle values obtained by experimental measurements. The migration of liquid water into copper and gold capillaries was measured by MD simulations and was found to differ from the modified LW equation. We found that the liquid layering in the vicinity of the solid surface induces a higher density and viscosity, leading to a slower MD uptake of fluid into the capillaries than was theoretically predicted. The near-surface viscosity for the nanoscale-confined water was defined and calculated for the thin film of water that was sheared between the two solid surfaces, as the ratio of water shear stress to the applied shear rate. Considering the effects of both the interface viscosity and slip length of the fluid, we successfully predicted the MD-measured fluid rise in the nanotubes.
  • Article
    Citation - WoS: 60
    Citation - Scopus: 62
    A Bodipy-Based Reactive Probe for the Detection of Au(iii) Species and Its Application To Cell Imaging
    (Royal Society of Chemistry, 2014) Üçüncü, Muhammed; Emrullahoğlu, Mustafa
    A BODIPY-based fluorescent probe bearing a pyridyl hydrazone motif responds selectively to Au(III) ions through an irreversible C[double bond, length as m-dash]N bond hydrolysis reaction. Gold species, besides their ability to catalyse chemical transformations in organic synthesis,1 have significant impacts on human health.2,3 Gold-based drugs have long been used in the treatment of rheumatoid arthritis and other autoimmune diseases.2 At the same time, when accumulated in the biological system at certain concentrations, gold species have the potential to disturb a series of cellular processes by irreversible interaction with biomolecules.3 In recent years, fluorescence-based sensing has become an indispensable tool for sensitive and accurate detection of trace levels of metal species in the solution.4 In addition, with the aid of fluorescence microscopy it has become possible to track metal species in living cells, which is of crucial importance for elucidating their roles in the biological system.