Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 7Citation - Scopus: 8Ascorbic Acid Enhances the Metabolic Activity, Growth and Collagen Production of Human Dermal Fibroblasts Growing in Three-Dimensional (3D) Culture(Gazi Üniversitesi, 2023) Dikici, SerkanTissue engineering (TE) enables the development of functional synthetic substitutes to be replaced with damaged tissues and organs instead of the use of auto or allografts. A wide range of biomaterials is currently in use as TE scaffolds. Among these materials, naturally sourced ones are favorable due to being highly biocompatible and supporting cell growth and function, whereas synthetic ones are advantageous because of the high tunability on mechanical and physical properties as well as being easy to process. Alongside the advantages of synthetic polymers, they mostly show hydrophobic behavior that limits biomaterial-cell interaction and, consequently, the functioning of the developed TE constructs. In this study, we assessed the impact of L-Ascorbic acid 2-phosphate (AA2P) on improving the culture conditions of human dermal fibroblasts (HDFs) growing on a three-dimensional (3D) scaffold made of polycaprolactone (PCL) using emulsion templating. Our results demonstrated that AA2P enhances the metabolic activity and growth of HDFs as well as collagen deposition by them when supplemented in their growth medium at 50 µg/mL concentration. It showed a great potential to be used as a growth medium supplement to circumvent the disadvantages of culturing human cells on a synthetic biomaterial that is not favored in default. AA2P's potential to improve cell growth and collagen deposition may prove an effective way to culture human cells on 3D PCL PolyHIPE scaffolds for various TE applications.Article Yüksek Derecede Kurum Üreten 2b Gazyağı/hava Difüzyon Alevleri Üzerinde Diferansiyel Yayılımın ve Basıncın Etkileri(Gazi Üniversitesi, 2024) Korucu, Ayşe; Miller, RichardBu çalısmada, dört farklı ortam basıncında kurum, oluşum ve yıkım süreçlerini incelemek amacıyla, yoğun kurum üreten Gazyağı/Hava alevleri, gerçek gaz (GG) ve ideal gaz (İG) hal denklemleri ve Lewis (Le) sayısının bir olarak kabul edildiği modeller ele alınmıştır. Yarı-genel kurum oluşum ve yıkım modelini içeren indirgenmiş Gazyağı/Hava mekanizması (29-adım, 10 çeşit gaz) 2 boyutlu (2B) Direk Sayısal Simülasyon (DNS) verilerini oluşturmak için MPI FORTRAN ile kodu yazılmış bir program kullanılmıştır. Le sayısının bire eşit kabul edildiği alev tahminlerinin, Le sayısının bire eşit olmadığı (genelleştirilmiş difüzyon) durumların sayısal sonuçlarından elde edilen alev yapısı ve kurum özelliklerinin istatiksel olarak benzerlik sağlayıp sağlamadığı araştırılmıştır. Bu bağlamda yapılan çalışmanın sonucunda, ortam basınçları 1, 5, 10 ve 35 atm olan Le sayısının bir olarak kabul edildiği GGLE ve İGLE modelleri ile üretilmiş 2B DNS alev tahminlerinin kurum özelliklerinin ve alev yapılarının yanlış hesaplanmasına yol açtığı belirlenmiştir.Article Eğitim yapılarında asansör trafik analizi yöntemlerinin karşılaştırılmasına yönelik bir araştırma(Gazi Üniversitesi, 2023) Deligöz, Dostcan; Harputlugil, TimuçinPurpose: Regarding elevator design in educational buildings; It is aimed to investigate the legal framework, to integrate dynamic simulation programs to design process, to compare traditional and dynamic simulation methods, to evaluate the adequacy of elevator features specified in the legislation and to determine the optimum scenarios according to the minimum requirements.Theory and Methods: Based on the findings of the literature review, which examines the issue of elevator traffic analysis together with the legislation and regulations, the carrying capacities of the elevators in the educational buildings designed by the Ministry of National Education (MNE) are tested. The stability of the system is tested by analyzing the conditions where only the disabled, disabled and building workers can be used together and all building users can use the elevators with the dynamic simulation method (with Elevate Software). The limits of the system are determined based on the waiting times during the peak usage periods. The findings of the study are evaluated according to the waiting times determined by CIBSE Guide D and the Chamber of Mechanical Engineers followed by the discussion of the outcomes.Results: The issue of elevator design has been overlooked in educational buildings, and a comprehensive elevator traffic analysis method has not been defined. For the effective use of all occupants, elevator design should be handled comprehensively with considering potentials of dynamic simulation method.Conclusion: According to the findings of the study, it is noted that the number and capacity of elevators in the legislation for educational buildings are determined only for minimum conditions and for disabled users. In addition, the legislation (considering calculation methodology) is not specific for educational buildings but related with buildings in general with public use. Considering the occupants, and their profiles of the educational buildings, a more comprehensive traffic analysis with the dynamic simulation method may enable the elevators to be designed and to be used more efficiently.Article Geleneksel Konutlarda Günışığı Aydınlığının Değerlendirilmesi: Kula Geleneksel Konutlarında Başoda(Gazi Üniversitesi, 2023) Battal, Cansu; Kazanasmaz, Zehra Tuğçe; İpekoğlu, BaşakDaylighting is one of the main factors among the features that determine the original space qualities in traditional houses. Illuminating the space with daylight also determines its ambience. Daylighting criteria should be considered among the features to be preserved in the usage decisions. In traditional dwellings in Anatolia, the main room is the most lavish room, which has projections and is surrounded by windows on three sides. Therefore, in the buildings which are conserved for reuse, the main room should maintain its original daylighting features. The aim of this study is to draw attention to the maintenance of daylighting features in the restoration decisions of traditional dwellings. Within the scope of the study, daylight performance of the main rooms of Kaçiklar and Zabunlar Houses selected in Kula, Manisa was evaluated. The daylight illuminance of the main rooms was measured during the four seasons; by calculating the ratio of the window area to the floor and wall areas, reflectance of surface materials and normal-normal transmittance of window glass were calculated. Results showed that daylight illuminance of the main room in Kaçiklar House was not sufficient for all four seasons, while it was in Zabunlar House. As a result, while the restoration decisions are developed, opening the closed window in the main room of Kaçiklar House, cleaning the paint on the top windows and and selecting a light-coloured wall finishing material will increase the reflectance value and will positively affect the daylight illuminance; in Zabunlar House, on the other hand, removing the existing wooden glazing in the sofa in order to increase the daylight provided through the sofa and increasing the reflectance value by choosing a light-coloured wall finishing material will increase the daylight illuminance of the main room.Article Citation - WoS: 1Citation - Scopus: 1Fragility Analysis of Wide-Beam Infill-Joist Block Rc Frames(Gazi Üniversitesi, 2022) Dönmez, Cemalettin; Karaarslan, Enes; Erberik, Murat AltuğPurpose: The purpose of the presented study is to develop fragility curves for the wide-beam infill-joist block reinforced concrete structures. Theory and Methods: Nonlinear time history analyses are performed for the set of selected ground motions. The performance levels are identified through pushover analysis and fragility curves are produced for ground motion parameters. Results: Fragility curves obtained for the wide-beam RC frames presents a different characteristic than the curves obtained for the conventional frames. Conclusion: Results show that wide-beam RC frame buildings are seismically more vulnerable than the conventional deep beam RC frame buildings based on structural models with similar properties. The possible reason seems to be low lateral stiffness of wide-beam frames that causes large lateral drift demands and therefore severe damage at the wide-beam column connections.Article İzmir’de Bir Osmanlı Dönemi Konağının Tavan ve Duvar Resimlerinin Yapım Tekniği ve Malzeme Özellikleri(Gazi Üniversitesi, 2021) Şerifaki, Kerem; İpekoğlu, BaşakKültür varlıklarımızın en hassas bileşenlerinden olan duvar resimlerinin korunmasında, resimlerin özgün malzeme özellikleri ve yapım tekniğinin belirlenmesi önemli aşamalardan biridir. Bu çalışma kapsamında İzmir Bayraklı’da yer alan Yahya Hayati Paşa Konağı’nın duvar ve tavan resimlerinin yapım tekniği ve malzeme özellikleri 2010 yılında yapıya ağır hasar veren yangın öncesinde alınan örnekler üzerinde gerçekleştirilen analizler ile belirlenmiştir. Duvar resimlerinin sıva ve astar tabakalarının, boyayı oluşturan bağlayıcı malzeme ile pigmentlerin mikro-yapısal özellikleri, mineralojik ve kimyasal kompozisyonları; optik mikroskop, kızılötesi spektroskopisi, X ışınları kırınım cihazı (XRD) ve EDS üniteli taramalı elektron mikroskobu kullanılarak tespit edilmiştir. Çalışma, resimlerin kireç sıva üzerinde yer alan organik bağlayıcı ve çeşitli beyaz pigmentlerden oluşan hazırlık tabakaları üzerinde yağlı boya tekniği ile uygulandığını göstermiştir. Resimlerin yapımında bitkisel yağın rengini beyazlatmak amacıyla çinko oksit (ZnO), kurşun beyazı $(PbCO_3)$ ve baryum beyazı $(BaSO_4)$ kullanıldığı belirlenmiştir. Resimlerin yapımında kırmızı için vermiyon (HgS), mavi için ultramarin $(N_{a6-10}Al_6Si_6O_{24}S_{2-4})$, yeşil için zümrüt yeşili $(3Cu(AsO_2)_2.Cu(CH_3COO)_2)$ ve kahverengi için kırmızı okra $(Fe2O_3$, kil mineralleri) kullanıldığı tespit edilmiştir. Bu ana pigmentler dışında, dolgu malzemesi olarak kullanılan baryum beyazı (BaSO4) ve kurşun kırmızısı pigmentinin $(Pb_3O_4)$bozulma ürünlerinden biri olan anglezit (PbSO4) tespit edilmiştir. Çalışma, yanarak yok olmuş bir kültür varlığının süslemelerinin yapım tekniği ve malzeme özelliklerinin belgelenmesi ile yapının onarımı aşamasına veri oluşturacaktır.Article Citation - WoS: 3Citation - Scopus: 5Helenistik Kulelerde Yanal Yüke İlişkin Düzlem İçi ve Düzlem Dışı Duvar Davranışının Duvar Profilleri ve Açıklık Düzenlerine Bağlı Olarak İncelenmesi(Gazi Üniversitesi, 2020) Gençer, Funda; Turan, Mine; Aktaş, EnginDry masonry wall profiles constructed without using bonding material between blocks are encountered in different building types dated to Greek, Hellenistic and Roman periods. Depending on development of earthquake experiences, dry masonry wall profiles vary in terms of wall thickness, number of layers, relationship of layers and size, form, organization and relationship of blocks. In this study, the construction details increasing the structural strength in watch towers constructed in Hellenistic Period are aimed to be determined. This study is limited with investigation of effect of wall profiles and opening organizations on in-plane and out-of-plane wall behaviors under lateral loading. Primarily, wall profiles and opening types of dry masonry towers in ancient Caria, Pamphylia and Cilicia regions, that have not lost authenticity and integrity or had information about their authentic form, were documented. By using gathered data, hypothetic towers with different wall profiles and opening types are designed. To determine in-plane and out-of-plane wall behavior of hypothetic towers, simulation of quasi-static tilt analysis based on equilibrium were carried out, and form changes at walls and collapse angles of towers were identified. Wall profile and opening properties effecting on structural strength under lateral loading were determinedd.Article Citation - WoS: 1Citation - Scopus: 2Oluklu alüminyum sandviç panellerde kor yüksekliğinin enerji sönümleme kapasitesine olan etkisi(Gazi Üniversitesi, 2020) Kılıçaslan, Cenk; Güden, MustafaIn this study, energy absorbing capacity of brazed and polyurethane adhesively bonded corrugated aluminum sandwich panels were investigated. In sandwich panels, Al 1050 H14 trapezoidal zig-zag corrugated cores and face and interlayer sheets were used. Each sandwich panel has core orientation of 0 degrees/0 degrees or 0 degrees/90 degrees. The cores used in these panels were smaller, core height is about 3 mm, in contrast to conventional sandwich cores. Impact tests were conducted at 3 and 6 m/s with spherical projectors. Adhesively bonded sandwich panels were also tested at 6 m/s with flat and conical projectors. Numerical models were prepared in LSDYNA to investigated the deformation behavior of cores. Panels tested with flat and conical projectors experienced complete perforation and absorbed more energy at configuration of 0 degrees/0 degrees core orientation. However, panels tested with spherical projectors were not perforated and they absorbed more energy at configuration of 0 degrees/90 degrees core orientation. Energy absorbing capacity of the panels were also compared to the panels having 9 mm height corrugated cores. The results showed that effective collapsing length was seen to increase due to increase in core height and impact energy distributed the whole panel surface more homogenous manner.Article Citation - WoS: 1Citation - Scopus: 1Potansiyel Doksorubisin Taşıyıcı Sistemi Olarak Peg-endozom Parçalayıcı Peptit Konjugatının Değerlendirilmesi(Gazi Üniversitesi, 2020) Şen, Selin; Top, AybenIn this study, it was aimed to develop a doxorubicin (DOX) carrier system based on a PEGylated TAT-derived cell penetrating peptide (G(2)RQR(3)QR(3)G(2)S) and to investigate drug release, self-assembly and stability properties of the carrier system. In the preparation of the drug delivery system, denoted as mPEG-peptide-oxime-DOX, methoxypolyethylene glycol (mPEG) with M-n=1900 Da was used. DOX was attached to the mPEG-peptide carrier system via acid cleavable oxime bond. Control drug delivery system, lack of the peptide (mPEG-oxime-DOX) was also synthesized to assess the effect of the peptide on the physicochemical and DOX release properties of the carrier system. mPEG-oxime-DOX exhibited a pH programmed DOX release with respective % DOX release values of similar to 68% and similar to 28% at pH 5.0 and at pH 7.4 at the end of 54 h. For the mPEG-peptide-oxime-DOX, on the other hand, quite low DOX release (similar to 10-15 %) was observed for both pH values suggesting possible interactions between DOX and the peptide. Initial median size value (D50) of the mPEG-oxime-DOX was measured as similar to 24 nm, independent of pH. However, for the mPEG-peptide-oxime-DOX, quite lower D50 values (similar to 3 nm and similar to 6 nm at pH 5.0 and pH 7.4, respectively) were obtained due to the repulsions between the arginines in the peptide sequence. Sizes of both drug delivery systems, tended to increase upon incubation at physiological conditions for 1 day suggesting that longer PEG chains should be used to enhance the stability of the mPEG-peptide-oxime-DOX and mPEG-oximeDOX systems.Article Citation - WoS: 8Citation - Scopus: 9Çelik Fiber Katkılı Etriyesiz Betonarme Kirişlerin Davranışı(Gazi Üniversitesi, 2017) Saatçi, Selçuk; Batarlar, BaturaySunulan çalışmada çelik fiber katkısının farklı boyuna donatı oranlarına sahip etriyesiz betonarme kirişlerineğilme davranışına olan etkileri deneysel ve analitik olarak incelenmiştir. Yapılan deneysel çalışmada düşükve yüksek boyuna donatı oranına sahip iki grup kiriş imal edilmiştir. Her bir gruptaki kirişlerhacimce %0, %0,5, %1,0 ve %1,5 çelik fiber oranına sahip olup toplam sekiz kiriş açıklık ortasına uygulananyük altında test edilmiştir. Düşük boyuna donatı oranına sahip kirişlerde çelik fiber katkısı eğilme kapasitesini %50'ye yakın oranlarda arttırmış, ancak deformasyonların tek bir çatlakta toplanması sebebiyleboyuna donatıda kopmaya yol açarak çelik fiber katkısız kirişe göre daha az yerdeğiştirme yapmasına sebepolmuştur. Yüksek boyuna donatı oranına sahip kirişlerde ise çelik fiber katkısı etriye görevi görerek çelikfiber katkısı olmaması durumunda gevrek eğik çekme göçmesi gösteren kirişlerin sünek eğilme göçmesigöstermelerini sağlamıştır. Her iki grupta çelik fiber oranının arttırılması çatlak dağılımını etkilemeklebirlikte davranışta önemli bir farklılığa yol açmamıştır. Kirişler analitik yöntemlerle modellendiğindeliteratürde yaygın kullanılan ve çatlakta çelik fiberlerin taşıdığı çekme gerilmesini sabit kabul edenyaklaşımın güvenli tarafta olmakla birlikte eğilme kapasitesinin olduğundan düşük hesaplanmasına yolaçtığı, çekme gerilmelerini çatlak genişliği ile ilişkilendiren daha hassas modellerin daha iyi sonuçverebilecekleri görülmüştür