Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 61Citation - Scopus: 64Electrospun Gelma Fibers and P(hema) Matrix Composite for Corneal Tissue Engineering(Elsevier Ltd., 2021) Arıca, Tuğçe A.; Güzelgülgen, Meltem; Yıldız, Ahu Arslan; Demir, Mustafa MuammerThe development of biocompatible and transparent three-dimensional materials is desirable for corneal tissue engineering. Inspired from the cornea structure, gelatin methacryloyl-poly(2-hydroxymethyl methacrylate) (GelMA-p(HEMA)) composite hydrogel was fabricated. GelMA fibers were produced via electrospinning and covered with a thin layer of p(HEMA) in the presence of N,N?-methylenebisacrylamide (MBA) as cross-linker by drop-casting. The structure of resulting GelMA-p(HEMA) composite was characterized by spectrophotometry, microscopy, and swelling studies. Biocompatibility and biological properties of the both p(HEMA) and GelMA-p(HEMA) composite have been investigated by 3D cell culture, red blood cell hemolysis, and protein adsorption studies (i.e., human serum albumin, human immunoglobulin and egg white lysozyme). The optical transmittance of the GelMA-p(HEMA) composite was found to be approximately 70% at 550 nm. The GelMA-p(HEMA) composite was biocompatible with tear fluid proteins and convenient for cell adhesion and growth. Thus, as prepared hydrogel composite may find extensive applications in future for the development of corneal tissue engineering as well as preparation of stroma of the corneal material. © 2020 Elsevier B.V.Article Citation - WoS: 8Citation - Scopus: 7Engineered Silica Nanoparticles Are Biologically Safe Vehicles To Deliver Drugs or Genes To Liver Cells(Elsevier Ltd., 2021) Tüncel, Özge; Kahraman, Erkan; Bağcı, Gülsün; Atabey, Neşe; Özçelik, SerdarEngineered silica nanoparticles (SiNP) are emerging materials for medical applications. Evaluating biological responses of specific cells treated with engineered silica nanoparticles is however essential. We synthesized and characterized the physicochemical properties of silica nanoparticles with two different sizes of 10 and 100 nm (10SiNP and 100SiNP) dispersed in cell culture medium. HuH-7, an epithelial-like human hepatoblastoma cell line and SK-HEP-1, a liver sinusoidal endothelial cell line (LSEC) are employed to evaluate their biological responses for the SiNP treatment. Primary human lymphocytes are used to assess genotoxicity recommended by OECD guidelines while erythrocytes are used to assess hemolytic activity. The engineered silica nanoparticles are not able to produce radical species, to alter the mitochondrial membrane potential, and induce any adverse effects on cell proliferation. The colony formation ability of HuH-7 hepatoblastoma cells was not affected following the SiNP treatment. Furthermore, SiNPs do not induce hemolysis of red blood cells and are not genotoxic. These findings suggest that SiNPs regardless of the size, amount, and incubation time are biologically safe vehicles to deliver drugs or genes to the liver. © 2020 Elsevier B.V.Book Part Citation - WoS: 30Citation - Scopus: 41Nanocarriers for Plant-Derived Natural Compounds(Elsevier Ltd., 2017) Bayraktar, Oğuz; Erdoğan, İpek; Köse, Merve D.; Kalmaz, GülcanNatural products constitute a large fraction in drug discovery processes. The term includes compounds from plants, microorganisms, and animals. Most of the natural products are secondary metabolites derived from plants, which are low in amounts and difficult to isolate. Another issue is the preservation of their bioactivity during process and storage as well as degradation in the gastrointestinal system before reaching circulation. Advances in nanotechnology offer nanoparticles, nanocapsules, and conjugates, which are devoted to site-specific, time-controlled delivery of bioactive agents. Nanoencapsulated systems have the advantage of high drug encapsulation efficiency because of optimized drug solubility in the core, low polymer content compared to other nanoparticulated systems such as nanospheres, drug polymeric shell protection against degradation factors, and the reduction of tissue irritation caused by the polymeric shell. This chapter will discuss nanoencapsulation methods and advances in carrier systems for plant-derived natural compounds.Article Citation - WoS: 1Citation - Scopus: 1The Rhythm in the Corridors of Virginia Woolf's Mind(Elsevier Ltd., 2009) Bezircilioğlu, SinemVirginia Woolf was one of the most distinctive writers of the English Literature using the stream of consciousness technique masterfully. The stream of consciousness technique is one of the most challenging narrative techniques in writing. In both reading and teaching, this technique requires a lot of study. This study focuses on the teaching of the stream of consciousness technique taking Virginia Woolf's technical artistry in her use of sentence structure and vocabulary. Putting special emphasis on Virginia Woolf's technical artistry while dealing with this challenging technique, we hope that it will be easier to understand Woolf's style better. The thematic analysis of her works is not enough. In this study, we dealt with Virginia Woolf's three novels; Mrs Dalloway, To the Lighthouse, and The Waves. These are Virginia Woolf's well-known novels, which are considered to show her mastery in the use of stream of consciousness technique in an effective way. First, it is possible to say that in each of the books mentioned above; a different way of the stream of consciousness technique is used, which makes it peculiar to Virginia Woolf. Despite the fact that she deals with each work differently, there are some specific points common in all three of these books. Although the works are in the form of a prose, they are closer to poetry, especially To the Lighthouse and The Waves. Her vocabulary choice and the sentence structure causes the reader to feel that he is reading a poem in the form of prose. This is related to Woolf's passion to find a new narration style. She combines poetry and prose so successfully that her works are both tempting and hard to read. This study is an examination of some of the techniques Virginia Woolf used in order to create poetry in the form of prose. The structures of balance and sound as well as the use of parenthesis are analyzed in this study. This work increases our understanding of Woolf's stream of consciousness technique while we are walking along the corridors of her mind.Book Part Citation - WoS: 12Citation - Scopus: 16Zein and Its Composites and Blends With Natural Active Compounds: Development of Antimicrobial Films for Food Packaging(Elsevier Ltd., 2016) Yemenicioğlu, AhmetIn this chapter the current developments in using biopolymer zein for active edible film-making are discussed with particular emphasis on antimicrobial packaging. Recent studies have showed the possibility of developing effective antimicrobial edible packaging materials through the incorporation of different natural antimicrobial compounds, including antimicrobial enzymes, peptides, and phenolic compounds, into zein films. The zein-based films that contain antimicrobial enzyme lysozyme and bacteriocin nisin have great potential as antilisterial edible packaging materials. Additionally, zein-based films that contain natural phenolic compounds might be suitable for antimicrobial, antioxidant, and/or bioactive packaging. The use of composites of zein with waxes and blends of zein with fatty acids enables researchers to obtain antimicrobial zein-based films with controlled release properties.Book Part Citation - WoS: 10Citation - Scopus: 16Plant-Microbe Interactions in Phytoremediation(Elsevier Ltd., 2014) Özyiğit, İbrahim İlker; Doğan, İlhanOur atmosphere, water resources and soil are becoming increasingly contaminated with inorganic and organic compounds as a result of anthropogenic-driven inputs, mainly from industry, mining, motorized traffic, agriculture, logging and military actions. Alleviation and prevention of environmental pollution can be achieved by utilization of plants and their associated microbes. Recent advances in plant-microbe interaction research revealed that plants are able to shape their rhizosphere microbiome through active secretion of substrates that are known to vary between plant species. Soil-borne microorganisms such as actinobacteria, algae, protozoa and different types of bacteria having different capabilities of functional activities can vary extensively in soils and occur in associations in the rhizosphere of plants. Microbial associations are known to affect mobility and availability of substances to the plant through the release of chelating agents, acidification, phosphate solubilization and redox changes and exudates derived from the plant can help to stimulate the survival and action of these microorganisms. A broad knowledge about the mechanisms in plants for the uptake, translocation, storage, and detoxification of contaminants, and interactions between plants and microorganisms are critical in developing technologies and best management practices for environmental clean-up. A comprehensive understanding of interactions between plants and rhizospheric microorganisms in the rhizosphere and plant-based processes will provide new opportunities to develop more efficient plants and better management practices for removal of contaminants. This chapter reviews plant-microbe interactions in phytoremediation with particular reference to the microbial dynamics in the rhizosphere of plants growing on contaminated soils.Book Part Citation - WoS: 7Citation - Scopus: 14Olive Oil Adulteration With Sunflower and Corn Oil Using Molecular Fluorescence Spectroscopy(Elsevier Ltd., 2010) Öztürk, Betül; Arıkan, Aysun; Özdemir, DurmuşAdulteration of olive oil with cheaper substitutes such as sunflower and corn oil is a major concern for the public. Rapid analysis methods are required for a quick and easy screening of possible adulteration attempts. Fluorescence spectroscopy coupled with a genetic algorithm-based multivariate calibration method allows the determination of olive oil adulteration with sunflower and corn oil. Because the standard error of prediction values are all below 1.30% (w/w) for the ternary set, fluorescence spectroscopy can be used as a fast screening method for possible olive oil adulteration with cheaper vegetable oils. In addition, the genetic algorithm used in the genetic inverse least squares (GILS) method is able to select and extract the most relevant information to build successful calibration models that have high predictive ability for the independent test samples.Conference Object Citation - WoS: 6Citation - Scopus: 8The Effect of Spatial Interventions on Historic Buildings' Indoor Climate (case Study: Tire Necip Paşa Library, Izmir-Turkey)(Elsevier Ltd., 2017) Coşkun, Turgay; Gülhan, Özcan; Şahin, Cem Doğan; Durmuş Arsan, Zeynep; Gökçen Akkurt, GüldenThe indoor climate of historic libraries should meet rigorous requirements related to human thermal comfort and conservation of books, manuscripts and cultural proper-ties. Paper based collections in historic libraries can be deteriorated chemically, mechanically and biologically because of inadequate indoor climate conditions. In this paper, Necip Paşa Library, the historic library located in Tire-Izmir, Turkey, was selected as a case study. The chemical, mechanical and biological degradation risks on the manuscripts were evaluated based on the indoor climate parameters measured for one year period. The Library, consisting of a main hall, a manuscript zone and an entrance hall, was modelled via the dynamic simulation software, Design Builder. Calibration of the model was conducted with respect to the measured indoor temperature and relative humidity values. The portico/Revak at the south facade of Library was converted into the entrance hall by wooden framed windows in 1930. To be able to see the effect of that intervention on the indoor climate (correspondingly on degradation risk of the manuscripts), a new model, namely semi-open model, was created and simulated. A remarkable change has not been observed on chemical degradation risk when the results of semi-open and existing library models were compared, while mechanical and biological degradation risks were less in semi-open model.Conference Object Citation - WoS: 21Citation - Scopus: 27Applying Underfloor Heating System for Improvement of Thermal Comfort in Historic Mosques: the Case Study of Salepçioglu Mosque, Izmir, Turkey(Elsevier Ltd., 2017) Bughrara, Khaled S. M.; Durmuş Arsan, Zeynep; Gökçen Akkurt, GüldenMosques differ from other types of buildings by having an intermittent operation schedule. Due to five prayer times per day throughout the year, mosques are fully or partially, yet periodically, occupied. This paper examines the potential of using an underfloor heating system for improvement of indoor thermal comfort in a historic mosque, which is naturally ventilated, heated and cooled, based on adaptive thermal comfort method. The selected Salepçioǧlu Mosque, housing valuable wall paintings, was built in 1905 in KemeraltI, Izmir, Turkey. It requires specific attention with its cultural heritage value. Firstly, indoor microclimate of the Mosque was monitored for one-year period of 2014-15. Then, dynamic simulation modelling tool, DesignBuilder v.4.2 was used to create the physical model of the Mosque. The ASHRAE Guideline 14 indices were utilized to calibrate the model, by comparing simulated and measured indoor air temperature to achieve hourly errors within defined ranges. The results of calibrated baseline model indicate that the Mosque does not satisfy acceptable thermal comfort levels for winter months that provided by the adaptive method. Then, the effect of underfloor heating was examined in the second model by the.Conference Object Citation - WoS: 4Citation - Scopus: 5Micromechanical Modelling of Size Effects in Microforming(Elsevier Ltd., 2017) Yalçınkaya, Tuncay; Demirci, Aytekin; Simonovski, Igor; Özdemir, İzzetThis paper deals with the micromechanical modelling of the size dependent mechanical response of polycrystalline metallic materials at micron scale through a strain gradient crystal plasticity framework. The model is implemented into a Finite Element software as a coupled implicit user element subroutine where the plastic slip and displacement fields are taken as global variables. Uniaxial tensile tests are conducted for microstructures having different number of grains with random orientations in plane strain setting. The influence of the grain size and number on both local and macroscopic behavior of the material is investigated. The model is capable of capturing both size effect due to statistical distribution of the grains and their size taking into account the grain boundary conditions.