Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 8Citation - Scopus: 8The Effect of Single-Walled Carbon Nanotube (swcnt) Concentration on the Mechanical and Rheological Behavior of Epoxy Matrix(Springer Verlag, 2020) Ay, Z.; Tanoğlu, MetinThe improvement of Mode I fracture toughness of epoxy by the addition of single-walled carbon nanotubes (SWCNTs) is considered. To prepare nanocomposites, chemical-vapor-deposition-grown SWCNTs noncovalently functionalized with an ethoxylated alcohol was used as the additive and a diglycidyl ether of bisphenol-A-based epoxy as the matrix material. The SWCNTs were dispersed in the epoxy matrix via a mechanical stirrer and a 3-roll mill. The effect of their concentration (0.0125, 0.025, 0.05, 0.1, 0.3, and 0.5 wt.%) on the mechanical properties of the nanocomposites was investigated, and the optimum concentration was determined. Mode I fracture toughness (single-edge-notch 3-point bending) and tensile tests were carried out on neat epoxy and SWCNT-reinforced epoxy nanocomposites. The fractured surfaces of fracture toughness and tensile test specimens were examined by the SEM to reveal the effect of SWCNTs on their failure modes.Conference Object Measure on Time Scales With Mathematica(Springer Verlag, 2006) Ufuktepe, Ünal; Yantır, AhmetIn this paper we study the Lebesgue Delta-measure on time scales. We refer to [3, 4] for the main notions and facts from the general measure and Lebesgue Delta integral theory. The objective of this paper is to show how the main concepts of Mathematica can be applied to fundamentals of Lebesgue Delta- and Lebesgue Delta- measure on an arbitrary time scale and also on a discrete time scale whose rule is given by the reader. As the time scale theory is investigated in two parts, by means of alpha and rho operators, we named the measures on time scales by the set function DMeasure and NMeasure respectively for arbitrary time scales.Article Citation - WoS: 3Citation - Scopus: 5A Novel Thermophilic Hemoprotein Scaffold for Rational Design of Biocatalysts(Springer Verlag, 2018) Efua Aggrey Fynn, Joana; Sürmeli, Nur BaşakHemoproteins are commonly found in nature, and involved in many important cellular processes such as oxygen transport, electron transfer, and catalysis. Rational design of hemoproteins can not only inspire novel biocatalysts but will also lead to a better understanding of structure-function relationships in native hemoproteins. Here, the heme nitric oxide/oxygen-binding protein from Caldanaerobacter subterraneus subsp. tengcongensis (TtH-NOX) is used as a novel scaffold for oxidation biocatalyst design. We show that signaling protein TtH-NOX can be reengineered to catalyze H2O2 decomposition and oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) by H2O2. In addition, the role of the distal tyrosine (Tyr140) in catalysis is investigated. The mutation of Tyr140 to alanine hinders the catalysis of the oxidation reactions. On the other hand, the mutation of Tyr140 to histidine, which is commonly observed in peroxidases, leads to a significant increase of the catalytic activity. Taken together, these results show that, while the distal histidine plays an important role in hemoprotein reactions with H2O2, it is not always essential for oxidation activity. We show that TtH-NOX protein can be used as an alternative scaffold for the design of novel biocatalysts with desired reactivity or functionality. H-NOX proteins are homologous to the nitric oxide sensor soluble guanylate cyclase. Here, we show that the gas sensor protein TtH-NOX shows limited capacity for catalysis of redox reactions and it can be used as a novel scaffold in biocatalysis design. [GRAPHICS] .Article Effective Synthesis of Cetyl Palmitate Over Co-Precipitated Wo3-Zro2 Catalysts(Springer Verlag, 2018) Mutlu, Vahide N.; Yılmaz, SelahattinThis study is focused on the development of solid acid catalysts for the synthesis of long chain fatty acids. A series of WO3-ZrO2 catalysts were prepared by co-precipitation method and tested in the synthesis of cetyl palmitate. The effect of WO3 loading (10, 15, and 20 wt% WO3) and calcination temperature (700 and 800 degrees C) on the catalyst properties and activity was investigated. XRD and Raman analysis confirmed that WO3 loading stabilized the tetragonal zirconia phase. Higher calcination temperature enhanced the acidities of the catalysts. WO3-ZrO2 catalysts were found to be very efficient for the synthesis of cetyl palmitate with high selectivity. These catalysts were tested for different reaction temperatures (135 and 162 degrees C), feed composition and catalyst amounts. The highest cetyl palmitate yield (98.4%) was obtained over the catalyst calcined at 800 degrees C with 15 wt% WO3, which had the highest total acidity. The catalysts preserved their activities up to three reuse.Article Citation - WoS: 10Citation - Scopus: 13Analysis of European Hazelnut (corylus Avellana) Reveals Loci for Cultivar Improvement and the Effects of Domestication and Selection on Nut and Kernel Traits(Springer Verlag, 2019) Frary, Amy; Öztürk, Süleyman Can; Balık, Hüseyin İrfan; Kayalak Balık, Selda; Kızılcı, Gökhan; Doğanlar, Sami; Frary, AnneTurkey is a rich source of European hazelnut (Corylus avellana) germplasm with nearly 400 accessions in the national collection. This genetic material encompasses cultivars, landraces and wild genotypes which were characterized for 12 nut and 13 kernel traits over 2years in the 1990s. Analysis of these attributes revealed both the positive and negative impacts that human selection and breeding have had on hazelnut. Thus, while selection has resulted in larger nuts and kernels, cultivars have fewer nuts per cluster and kernels with larger internal cavities. Breeding has also resulted in a propensity for cultivars to have higher proportions of double kernels and empty nuts, two traits which reduce quality and yield. In addition, it is clear that while selection has successfully increased hazelnut fat content it has not impacted overall flavor, a much more complex trait. The nut and kernel phenotypic data were combined with genotypic data from 406 simple sequence repeat marker alleles for association mapping of the quantitative trait loci (QTL) for the traits. A total of 78 loci were detected in the population with the highest proportions for nut (24%) and kernel (26%) appearance parameters followed by quality (19%), shell thickness (16%) and yield-related (15%) traits. It is hoped that some of the identified QTL will be useful for future breeding of hazelnut for improved nut and kernel yield and quality.Article Citation - WoS: 15Citation - Scopus: 19Genome-Wide Association Mapping of Yield Components and Drought Tolerance-Related Traits in Cotton(Springer Verlag, 2018) Akköse Baytar, Asena; Peynircioğlu, Ceng; Sezener, Volkan; Başal, Hüseyin; Frary, Anne; Frary, Amy; Doğanlar, SamiDrought causes serious yield losses in cotton production throughout the world. Association mapping allows identification and localization of the genes controlling drought-related traits which will be helpful in cotton breeding. In the present study, genetic diversity analysis and association mapping of yield and drought traits were performed on a panel of 99 upland cotton genotypes using 177 SSR (simple sequence repeat) markers. Yield parameters and drought tolerance-related traits were evaluated for two seasons under two watering regimes: water-stressed and well-watered. The traits included seed cotton yield (SCY), lint yield (LY), lint percentage (LP), water-use efficiency (WUE), yield potential (YP), yield reduction (YR), yield index (YI), drought sensitivity index (DSI), stress tolerance index (STI), harmonic mean (HM), and geometric mean productivity (GMP). The genotypes with the least change in seed cotton yield under drought stress were Zeta 2, Delcerro, Nazilli 87, and DAK 66/3 which were also the most water-use efficient cultivars. The average genetic diversity of the panel was 0.38. The linkage disequilibrium decayed relatively rapidly at 20–30 cM (r 2 ≥ 0.5). We identified 30 different SSR markers associated with the traits. Fifteen and 23 SSR markers were linked to the traits under well-watered and water-stress conditions, respectively. To our knowledge, most of these quantitative yield and drought tolerance-associated loci were newly identified. The genetic diversity and association mapping results should facilitate the development of drought-tolerant cotton lines with high yield in molecular breeding programs.Conference Object Low-Power and Low-Cost Stiffness-Variable Oesophageal Tissue Phantom(Springer Verlag, 2017) Thorn, Alexander; Afacan, Dorukhan; Ingham, Emily; Kavak, Can; Miyashita, Shuhei; Damian, Dana D.Biological tissues are complex structures with changing mechanical properties depending on physiological or pathological factors. Thus they are extendible under normal conditions or stiff if they are subject to an inflammatory reaction. We design and fabricate a low-power and low-cost stiffness-variable tissue phantom (SVTP) that can extend up to 250% and contract up to 5.4% at 5 V (1.4 W), mimicking properties of biological tissues. We investigated the mechanical characteristics of SVTP in simulation and experiment. We also demonstrate its potential by building an oesophagus phantom for testing appropriate force controls in a robotic implant that is meant to manipulate biological oesophageal tissues with changing stiffness in vivo. The entire platform permits efficient testing of robotic implants in the context of anomalies such as long gap esophageal atresia, and could potentially serve as a replacement for live animal tissues.Conference Object Citation - Scopus: 3Ontology Supported Policy Modeling in Opinion Mining Process(Springer Verlag, 2012) Husaini, Mus'ab; Ko, Andrea; Tapucu, Dilek; Saygın, YücelIn e-Society the spreading services offered by Social Web has changed the way of communication and cooperation among citizens, policy-makers, governance bodies and civil society actors. One of the main goals of policymakers is to motivate citizens for participation in policy-making processes. UbiPOL ((Ubiquitous Participation Platform for Policy-making, ICT-2009.7.3(ICT for Governance and Policy Modelling), 2009-2011) aimed to develop a ubiquitous solution, which emphasizes citizens' participation in policy-making processes (PMPs) regardless of their current location and time. Ontology-based opinion mining component of Ubipol system has a crucial role in citizens' commitment, because it empowers them to contribute in policy making. This paper presents the ontology-based semi-automatic approach and tool for sentiment analysis in Ubipol system, which include lexicon extraction from a large corpus of documents. Aspect-based opinion summarization of user reviews and its combination with domain ontology development are discussed as well.Article Citation - Scopus: 8The Second Case of Saposin a Deficiency and Altered Autophagy(Springer Verlag, 2018) Köse, Melis; Akyıldız Demir, Seçil; Akıncı, Gülçin; Eraslan, Cenk; Yılmaz, Ünsal; Ceylaner, Serdar; Sözmen Yıldırım, Eser; Seyrantepe, VolkanKrabbe disease is a lysosomal storage disease caused by galactosylceramidase deficiency, resulting in neurodegeneration with a rapid clinical downhill course within the first months of life in the classic infantile form. This process may be triggered by the accumulation of galactosylceramide (GalCer) in nervous tissues. Both the enzyme galactosylceramidase and its in vivo activator molecule, saposin A, are essential during GalCer degradation. A clinical manifestation almost identical to Krabbe disease is observed when, instead of the galactosylceramidase protein, the saposin A molecule is defective. Saposin A results from posttranslational processing of the precursor molecule, prosaposin, encoded by the PSAP gene. Clinical and neuroimaging findings in a 7-month-old child strongly suggested Krabbe disease, but this condition was excluded by enzymatic and genetic testing. However, at whole exome sequencing, the previously undescribed homozygous, obviously pathogenic PSAP gene NM_002778.3: c.209T>G(p.Val70Gly) variant was determined in the saposin A domain of the PSAP gene. Fibroblast studies showed GalCer accumulation and the activation of autophagy for the first time in a case of human saposin A deficiency. Our patient represents the second known case in the literature and provides new information concerning the pathophysiology of saposin A deficiency and its intralysosomal effects.Conference Object Citation - WoS: 11Citation - Scopus: 20Learning Styles Diagnosis Based on Learner Behaviors in Web Based Learning(Springer Verlag, 2009) Atman, Nilüfer; İnceoğlu, Mustafa Murat; Aslan, Burak GalipIndividuals have different backgrounds, motivation and preferences in their own learning processes. Web-based systems that ignore these differences have difficulty in meeting learners' needs effectively. One of these individual differences is the learning style. For providing adaptively incorporated learning styles, firstly learning styles of learners have to be identified. There are many different learning models in literature. This study is based on Felder and Silverman's Learning Styles Model and investigates only active/reflective and visual/verbal dimensions of this model. Instead of filling out a questionnaire, learner behaviors are analyzed with the help of literature-based approaches so that learning styles of learners can be detected.