Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 3Citation - Scopus: 3Roadmap on Multifunctional Materials for Drug Delivery(IOP Publishing, 2024) Nottelet, Benjamin; Buwalda, Sytze; van Nostrum, Cornelus F.; Zhao, Xiaofei; Deng, Chao; Zhong, Zhiyuan; Cheah, Ernest; Kehr, Nermin SedaThis Roadmap on drug delivery aims to cover some of the most recent advances in the field of materials for drug delivery systems (DDSs) and emphasizes the role that multifunctional materials play in advancing the performance of modern DDSs in the context of the most current challenges presented. The Roadmap is comprised of multiple sections, each of which introduces the status of the field, the current and future challenges faced, and a perspective of the required advances necessary for biomaterial science to tackle these challenges. It is our hope that this collective vision will contribute to the initiation of conversation and collaboration across all areas of multifunctional materials for DDSs. We stress that this article is not meant to be a fully comprehensive review but rather an up-to-date snapshot of different areas of research, with a minimal number of references that focus upon the very latest research developments.Review Citation - Scopus: 121Natural and Synthetic Nanovectors for Cancer Therapy(Ivyspring International Publisher, 2023) Eftekhari, Aziz; Kryschi, Carola; Pamies, David; Ahmadian, Elham; Janas, Dawid; Davaran, Soodabeh; Khalilov, Rovshan; Güleç, ŞükrüNanomaterials have been extensively studied in cancer therapy as vectors that may improve drug delivery. Such vectors not only bring numerous advantages such as stability, biocompatibility, and cellular uptake but have also been shown to overcome some cancer-related resistances. Nanocarrier can deliver the drug more precisely to the specific organ while improving its pharmacokinetics, thereby avoiding secondary adverse effects on the not target tissue. Between these nanovectors, diverse material types can be discerned, such as liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, etc., each of which offers different opportunities for cancer therapy. In this review, a broad spectrum of nanovectors is analyzed for application in multimodal cancer therapy and diagnostics in terms of mode of action and pharmacokinetics. Advantages and inconveniences of promising nanovectors, including gold nanostructures, SPIONs, semiconducting quantum dots, various nanostructures, phospholipid-based liposomes, dendrimers, polymeric micelles, extracellular and exome vesicles are summarized. The article is concluded with a future outlook on this promising field. © The author(s).Review Citation - WoS: 52Citation - Scopus: 56Spheroid engineering in microfluidic devices(American Chemical Society, 2023) Tevlek, Atakan; Keçili, Seren; Özçelik, Özge Solmaz; Kulah, Haluk; Tekin, H. CumhurTwo-dimensional (2D) cell culture techniques are commonly employed to investigate biophysical and biochemical cellular responses. However, these culture methods, having monolayer cells, lack cell-cell and cell-extracellular matrix interactions, mimicking the cell microenvironment and multicellular organization. Three-dimensional (3D) cell culture methods enable equal transportation of nutrients, gas, and growth factors among cells and their microenvironment. Therefore, 3D cultures show similar cell proliferation, apoptosis, and differentiation properties to in vivo. A spheroid is defined as self-assembled 3D cell aggregates, and it closely mimics a cell microenvironment in vitro thanks to cell-cell/matrix interactions, which enables its use in several important applications in medical and clinical research. To fabricate a spheroid, conventional methods such as liquid overlay, hanging drop, and so forth are available. However, these labor-intensive methods result in low-throughput fabrication and uncontrollable spheroid sizes. On the other hand, microfluidic methods enable inexpensive and rapid fabrication of spheroids with high precision. Furthermore, fabricated spheroids can also be cultured in microfluidic devices for controllable cell perfusion, simulation of fluid shear effects, and mimicking of the microenvironment-like in vivo conditions. This review focuses on recent microfluidic spheroid fabrication techniques and also organ-on-a-chip applications of spheroids, which are used in different disease modeling and drug development studies.Article Citation - WoS: 50Citation - Scopus: 50Hierarchically Porous Polymer Derived Ceramics: a Promising Platform for Multidrug Delivery Systems(Elsevier Ltd., 2018) Vakıfahmetoğlu, Çekdar; Zeydanlı, Damla; Özalp, Veli Cengiz; Borsa, Barış Ata; Soraru, Gian DomenicoMesoporous silicon oxycarbide (SiOC) components were formed with the use of “molecular spacer” (a sacrificial vinyl-terminated linear siloxane which while decomposing during pyrolysis generates pores with size proportional to the molecular weight), followed by a post-pyrolysis etching treatment by hydrofluoric acid (HF) to obtain C-rich SiOC samples having additional micro-/mesoporosity and specific surface area reaching to 774 m2/g. The biocompatibility of the samples was validated by hemolysis test, and their cargo/drug loading capacities were studied by two different sized polypeptides as model molecules. SiOC particles showed less hemolysis compared to the reference material MCM-41. Similarly, the loading capacity and the release kinetics of bovine serum albumin (BSA) and vancomycin-loaded SiOC particles were improved compared to that of MCM-41. In the multi cargo loading/release capacity tests, done by using different sized molecules, Bio2-HF and MCM-41 were loaded both with fluorescein and BSA. While a lagging time in fluorescein release was observed for MCM-41, the release kinetics of fluorescein and BSA was not affected when they are loaded together in the hierarchical pores of Bio2-HF, allowing the release of both large and small cargo molecules. The antimicrobial activity tests showed that Bio2-HF performed better than MCM-41 particles in improving bactericidal activity.