Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 16Citation - Scopus: 18Connexin 32 Induces Pro-Tumorigenic Features in Mcf10a Normal Breast Cells and Mda-Mb Metastatic Breast Cancer Cells(Elsevier, 2020) Yalçın Özuysal, Özden; Adak, Aslı; Ünal, Yağmur Ceren; Yücel, Simge; Vural, Zehra; Turan, Fatma Başak; Meşe, GülistanConnexins (Cx), the basic subunit of gap junctions, play important roles in cell homeostasis, and their abnormal expression and function are associated with human hereditary diseases and cancers. In tumorigenesis, connexins were observed to have both anti-tumorigenic and pro-tumorigenic roles in a context- and stage-dependent manner. Initially, Cx26 and Cx43 were thought to be the only connexins involved in normal breast homeostasis and breast cancer. Later on, association of Cx32 expression with lymph node metastasis of breast cancer and subsequent demonstration of its expression in normal breast tissue suggested that Cx32 contributes to breast tissue homeostasis. Here, we aimed to determine the effects of Cx32 on normal breast cells, MCF10A, and on breast cancer cells, MDA-MB-231. Cx32 overexpression had profound effects on MCF10A cells, decreasing cell proliferation by increasing the doubling time of MCF10A. Furthermore, MCF10A cells acquired mesenchymal-like appearance upon Cx32 expression and had increased migration capacity and expression of both E-cadherin and vimentin. In contrast, Cx32 overexpression altered the EMT markers of MDA-MB-231 by increasing the expression of mesenchymal markers, such as slug and vimentin, and decreasing E-cadherin expression without affecting their proliferation and morphology. Our results indicate, for the first time in the literature, that Cx32 has tumor-promoting roles in MCF10A and MDA-MB-231 cells.Article Citation - WoS: 69Citation - Scopus: 77Morphosynthesis of Caco3 at Different Reaction Temperatures and the Effects of Pdda, Ctab, and Edta on the Particle Morphology and Polymorph Stability(Elsevier Ltd., 2007) Altay, E.; Shahwan, Talal; Tanoğlu, MetinFacile precipitation of CaCO3 was performed using aqueous solutions of CaCl2 with Na2CO3 over a wide range of mixing and aging temperatures. The precipitation process was then repeated in the presence of PDDA, CTAB, and EDTA at the mixing temperatures of 30 °C, 50 °C, 70 °C, and 90 °C. The presence of these additives was seen to greatly suppress the formation of aragonite. Among these additives, EDTA was the one that showed the most prominent effects on particle morphology of CaCO3. The sequence of pH adjustment appeared to be a critical factor for the additive functionality.