Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 1Synthesis of Pristine Chitosan Foams with Enhanced Pore Structure, Surface Area, and Mechanical Strength for Tissue Engineering Applications(Iop Publishing Ltd, 2025) Polat, M.; Cropper, Chelsea; Ozdamar, A. B.; Polat, H.With its excellent biocompatibility, biodegradability, and antimicrobial activity, chitosan is a promising scaffold material for hard-tissue engineering. Yet, pristine chitosan foams typically lack the strength and porosity required for such use. Here we present a simple emulsion-templating approach to fabricate pristine chitosan foams with optimized strength and porosity. Sodium dodecyl sulfate (SDS), a widely used biocompatible anionic surfactant, was employed at trace levels to aid polymerization. The foams display a dual-scale pore morphology. Cavities of 150-300 mu m are separated by around 50 mu m thick chitosan walls containing large interconnecting openings. The walls are further populated with meso- and macropores of 50-500 nm. This architecture should support cell attachment and growth, facilitate proliferation, and enhance nutrient transport and metabolic exchange. The structure yields high surface area (up to 10 m2 g-1). Mechanically, the thick-walled cavities impart both elastic recovery and high compressive resistance (255 kPa at 40% strain from foams polymerized with 4% chitosan). A preliminary drug-release study using vancomycin confirmed excellent loading and sustained release.Article Citation - WoS: 8Citation - Scopus: 8Pore Connectivity Effects on the Internal Surface Electric Charge of Mesoporous Silica(Springer, 2019) Şen, Tümcan; Barışık, MuratNano-scale confinements within mesoporous systems develop overlapping electric double layers (EDL) such that the existing theoretical models cannot predict the electric potential distributions and resulting surface charges. In addition, ionic conditions undergo local variation through connections between the pore voids and pore throats. For the first time in literature, we studied the charging behavior of mesoporous silica in terms of the pore to throat size ratio (R-pt) to characterize the pore connectivity effects, in addition to porosity (epsilon) and pore size (H). Both local and average surface charge densities inside mesoporous silica were examined by varying these parameters systematically. Results showed that the magnitude of surface charge density decreased with increasing EDL overlap and decreasing connectivity effects. We formulized this behavior and developed an extended model to predict mesoporous silica's internal charge as a function of porosity, pore size, and pore to throat size ratio.