Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Influence of Innovative Thawing Approaches on the Thermal and Chemical Structure Changes of Frozen Beef Liver(Springer, 2026) Avsar, Nazlican; Uzuner, SibelFreezing effectively preserves meat quality, but the formation of ice crystals during the process can impact tenderness and functionality. Thawing is a critical step, as it can lead to physicochemical changes-such as protein oxidation and further ice crystal growth-that may reduce product quality and consumer appeal. Therefore, the thawing method plays a key role in determining the final quality of frozen meat. This study evaluated the physicochemical and structural characteristics of beef liver frozen at - 18 +/- 2 degrees C for 20 h and thawed using three methods: water immersion thawing (WIT), ultrasonic bath thawing (UBT), and air fryer thawing (AFT). No significant differences in drip loss were observed among the UBT, AFT, and WIT samples (p > 0.05). Color measurements (L*, a*, b*) were significantly higher in raw liver than in AFT and UBT samples (p < 0.05). Compared to raw liver and the WIT method, AF and UB thawing lowered the denaturation temperature, indicating reduced thermal stability. The lowest metmyoglobin (MetMb) content was found in the UBT sample (36.57 +/- 0.87%), followed by the AFT sample (41.71 +/- 1.29%), suggesting better pigment preservation with UB thawing. Highlights circle AF and UB thawing methods resulted in a lower denaturation temperature. circle UBT showed the lowest MetMb content, helping to minimize oxidation. circle UBT caused less damage to protein chains and better preserved structural stability. circle UBT preserved desirable aroma characteristics more effectively.Article A Phenomenological Kinetic Flotation Model: Intrinsic Floatability Profiling for Batch and Continuous Flotation Systems(Springer Heidelberg, 2026) Polat, Mehmet; Guzel, Veli; Kobas, Muammer; Polat, HurriyetThis study presents a mechanistic flotation kinetics model that unifies the description of mineral particle floatability in both batch and continuous systems. Building on a physically explicit interpretation of bubble-particle interactions, the model introduces the concept of intrinsic floatability, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\upphi }_{\text{P},\text{ij}}<^>{\text{s}}$$\end{document}, defined as the size-and composition-dependent probability that a particle within a bubble's sweep volume reports to the froth. A central feature of the framework is that \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\upphi }_{\text{P},\text{ij}}<^>{\text{s}}$$\end{document} is decoupled from system-level rate-determining factors, such as bubble-particle encounter frequency, transport limits, and bubble surface crowding-that otherwise confound attempts to extract floatability distributions from kinetic data. This separation is achieved through three explicit, time-dependent parameters: the encounter rate kappa(t), the limiting flotation rate mu(t), and the bubble saturation factor chi(t). Together, these parameters isolate intrinsic particle behavior from external constraints. The model naturally reduces to the classical first-order rate law in dilute pulps, while in concentrated suspensions it predicts systematic deviations, approaching zero-order kinetics as bubble surfaces saturate. Importantly, the same formulation applies seamlessly to batch tests and multi-stage continuous circuits, enabling a consistent theoretical framework across scales and ore types. Requiring only standard flotation data and known system parameters, the model is practical for both laboratory coal flotation studies and industrial non-coal applications. Validation using batch coal data and continuous plant-scale copper flotation results demonstrates its robustness and broad relevance.Article Comparative Optimization of Hot Water and Citric Acid Extraction Methods for Sericin Recovery From Silk Cocoons: In Vitro Antioxidant and Antidiabetic Activities(Springer, 2026) Sincar, Bahar; Ozdemir, Feyza; Bicakci, Beyza Tutku; Erdem, Cansu; Yalcin, Dilek; Alamri, Abdulhakeem S.; Bayraktar, OguzSilk sericin, a hydrophilic protein derived from Bombyx mori cocoons, has attracted increasing interest due to its antioxidant, moisturizing, and enzyme-inhibitory properties. Efficient extraction is essential to preserve its biofunctional potential. In this study, sericin was extracted using hot water and 1.25% (w/v) citric acid using autoclave-based heating to achieve pressurized conditions above 100 degrees C. A Box-Behnken Response Surface Methodology (RSM) was applied to systematically evaluate the effects of extraction parameters (temperature and time) and to optimize five key response variables: yield, purity, molecular weight and polydispersity index (PDI), total antioxidant capacity (ABTS), and alpha-glucosidase inhibition activity. The results revealed that higher temperatures (125 degrees C) produced the maximum sericin yield, while moderate conditions (115 degrees C for 45 min) ensured better preservation of antioxidant and antidiabetic activities. Hot acid extraction resulted in significantly enhanced purity and enzymatic inhibition compared to hot water extraction. Sericin fractions above 7 kDa exhibited the strongest bioactivity, as reflected by lower IC50 values in both ABTS and alpha-glucosidase inhibition assays. The optimized hot water citric acid-based method yielded 24.00% sericin with 100.00% purity and an IC50 of 0.67 mg/mL for alpha-glucosidase inhibition. This study compares hot water and hot acid autoclave extractions using Box-Behnken design and evaluates their effects on sericin yield, purity, and bioactivities. Citric acid-based extraction produced higher purity and stronger alpha-glucosidase inhibition, while hot water extraction preserved antioxidant potential more effectively. These findings support the use of citric acid as an eco-friendly and scalable extraction agent and highlight the potential of sericin in biomedical and nutraceutical applications.Article Effect of TiO2 and ZrO2 Additions on Sintering and Mechanical Properties of Dental Porcelain Material(Springer, 2025) Aouadja, Faycal; Toprak, Seyra; Demir, Mustafa M.; Boudchicha, Mohamed ReddaThis study investigates the influence of varying TiO2 (0-15 wt.%) and ZrO2 (15-0 wt.%) additions on the microstructure, densification, and mechanical properties of dental porcelain composites fabricated from local Algerian raw materials. The samples were produced by cold compaction and sintered at temperatures ranging from 1100 degrees C to 1250 degrees C. Advanced characterization techniques-X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy-were employed to analyze phase evolution and microstructural morphology. The results indicated that increasing TiO2 content while decreasing ZrO2 enhanced both densification and mechanical strength. The optimal composition-15 wt.% TiO2 sintered at 1200 degrees C-achieved the highest bending strength (177 MPa) and Martens hardness (2931 MPa). TiO2 functioned as a fluxing agent, promoting grain cohesion, whereas excessive ZrO2 content led to the formation of structural defects. These findings highlight the potential of optimized formulations to meet the requirements for high-performance, biocompatible dental ceramics and support the development of sustainable porcelain using abundant natural resources.Article On the Construction of Xor-Magic Graphs(Elsevier, 2026) Batal, AhmetA simple connected graph of order 2nis defined as a xor-magic graph of power n if its vertices can be labeled with vectors from Fn2 in a one-to-one manner such that the sum of labels in each closed neighborhood set of vertices equals zero. In this paper, we introduce a method called the self-switching operation, which, when properly applied to an odd xor-magic graph of power n, generates a xor-magic graph of power n + 1. We demonstrate the existence of a proper self-switching operation for any given odd xor-magic graph and provide a characterization of the cut space of a connected graph in the process. We also observe that the Dyck graph can be obtained from the complete graph of order 4 by applying three successive self-switching operations. Additionally, we investigate various graph products, including Cartesian, tensor, strong, lexicographical, and modular products. We observe that these products allow us to generate xor-magic graphs by selecting appropriate factor graphs. Notably, we discover that a modular product of graphs is always a xor-magic graph when the orders of its factors are powers of 2 (except for 2 itself). In the process, we realize that the Clebsch graph is the modular product of the cycle graph and the empty graph, each of order 4. By combining the self-switching operation with the modular product, we establish the existence of k-regular xor-magic graphs of power n for all n >= 2 and for all k is an element of {3, 5, 7, ... , 2n-5}boolean OR{2n-1}. We also prove that there is no (2n-3)-regular xor-magic graph of power n. Lastly, we introduce two more methods to produce xor-magic graphs. One method utilizes Cayley graphs and the other utilizes linear algebra. (c) 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article Citation - WoS: 1Citation - Scopus: 1Structural and Functional Tuning of ZIF-8 Nanoparticles Via Zinc Salt Variation and Ligand Ratio for Enhanced Drug Delivery(Springer, 2025) Mete, Derya; Sanli-Mohamed, GulsahThe clinical application of doxorubicin (DOX), a widely used chemotherapeutic agent, is limited by systemic toxicity, rapid clearance, and the development of multidrug resistance. Metal-organic frameworks (MOFs), particularly zeolitic imidazolate frameworks (ZIFs), have emerged as promising nanocarriers to overcome these limitations due to their high drug-loading capacity, pH-responsive release profiles, and favorable biocompatibility. Among them, ZIF-8 is especially attractive for its ability to selectively release drugs in acidic tumor microenvironments. However, the physicochemical and biological properties of ZIF-8 are highly sensitive to synthesis parameters, particularly the choice of zinc salt precursor and the Zn2+:ligand molar ratio. In this study, we systematically investigated the effects of four zinc salts (zinc nitrate, zinc acetate, zinc chloride, and zinc bromide) and three Zn2+:2-methylimidazole molar ratios (1:35, 1:70, and 1:200) on the synthesis, drug-loading efficiency, release behavior, and anticancer activity of DOX-loaded ZIF-8 (DOX@ZIF-8) nanoparticles. The resulting nanocarriers were characterized using scanning electron microscopy (SEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDX), inductively coupled plasma optical emission spectroscopy (ICP-OES), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area analysis. pH-responsive DOX release was evaluated under physiological (pH 7.4) and acidic (pH 5.0) conditions. Cytotoxicity was assessed in A549 lung cancer cells via the MTT assay. Additionally, in vitro time-lapse live-cell imaging and wound healing assays were conducted to evaluate intracellular drug uptake and cellular responses. Our findings highlight the critical influence of zinc salt selection and ligand ratio on the structure-property-function relationships of ZIF-8, providing valuable insights for the rational design of MOF-based nanocarriers in targeted cancer therapy.Article Effects of Industrial and Domestic Wastewater Treatment Plants on Microplastic Pollution in an Urban River in Türkiye(Springer int Publ Ag, 2025) Baycan, Neval; Alyuruk, Nefise; Kazanci, Yigithan; Alpergun, Cumana; Kara, Nursena; Tasdelen, Ozge; Gunduz, OrhanMicroplastic (MP) contamination in inland aquatic systems is a growing environmental concern due to its persistence and potential ecological impacts. This study provides a comprehensive assessment of the occurrence, composition, and seasonal dynamics of MPs in two urban rivers-Nif Creek and Gediz River-in western T & uuml;rkiye, which receive treated and untreated effluents from domestic and industrial wastewater treatment plants (WWTPs). A total of 20 river water and 3 sediment sampling stations were monitored across four seasons. MP concentrations ranged from 7 to 146 particles/L in water and from 9,867 to 136,177 particles/kg in sediments, with the highest abundances observed near WWTP outfalls and urban infrastructure. Polypropylene was the dominant polymer in water (59.1%) and WWTP effluents (44.4%), while polyethylene was most prevalent in sediments (60.2%). MPs were primarily within the 0.1-0.5 mm size range and were predominantly transparent in colour. Statistical analyses indicated significant positive correlations between MP abundance and key water quality parameters, including chemical oxygen demand, total suspended solids, and selected heavy metals (e.g., Zn, Cd, Ni). The polymeric composition of MPs reflected both urban and industrial sources, with variations in polymer profiles linked to spatial and seasonal factors. Compared to values reported in European freshwater systems, MP levels in the studied rivers were considerably higher, underscoring the need for improved wastewater management and targeted monitoring efforts in urban river basins.Article Development and Evaluation of 177Lu-Imatinib: Radiolabeling and Cell Culture Studies(Walter de Gruyter GmbH, 2025) Ozgenc, E.; Karpuz, M.; Guler, G.; Burak, Z.; Başpainar, Y.; Gundogdu, E.A.Targeted radiopharmaceuticals offer promising approaches for cancer diagnosis and therapy. This study developed freeze-dried kit formulations of 177Lu-Imatinib (IMT) and evaluated their potential efficacy through in vitro studies. Four formulations (F1-F4) containing IMT and chelating agents were prepared and characterized via Fourier transform infrared (FTIR), ultraviolet spectrum (UV), and thermogravimetric analysis (TGA) to confirm complex formation. Biocompatibility was assessed in NIH-3T3 cells using the MTT assay. Radiolabeling with 177Lu was optimized by varying pH, incubation time, and reactant ratios. Radiochemical purity and stability were analyzed over 7 days using HPLC. Binding affinity and cytotoxicity were evaluated in MCF-7 and NIH-3T3 cells. Spectroscopic analyses confirm successful complex formation. All formulations exhibited >90% viability in NIH-3T3 cells. Optimal radiolabeling conditions (45mg IMT-chelator, pH 5, 60min incubation) yielded >90% efficiency, with stable radiolabeling for 7 days. The 177Lu-IMT-DOTA (F3) formulation showed significantly higher binding and cytotoxic effects in MCF-7 cells compared to controls. The 177Lu-IMT-DOTA (F3) kit demonstrates high radiolabeling efficiency, stability, and selective in vitro cytotoxicity toward breast cancer cells, supporting its potential as a targeted radiopharmaceutical. © 2025 Walter de Gruyter GmbH, Berlin/Boston 2025.Article Industrial History and Heritage of the Karaburun Mercury Mining District, Türkiye(Taylor and Francis Ltd., 2025) Yılmazer, Aslıhan; Gönülal, Yasemin Özcan; Yüceer, HülyaMining metallic resources has been important to technological advancement since prehistoric times and has contributed to the progress of civilisation. Mining heritage includes sites and structures related to mining that reveal historical and cultural insights. The remains of structures in the mercury mining district on the Karaburun peninsula of Izmir in Türkiye, which includes the Kalecik, Karareis and Dikencik mines, is one such site. Despite its abandonment and subsequent damage, research has highlighted the importance of the district during the late Ottoman empire and the early years of the Republic as a source of cinnabar, the most common source ore for refining elementary mercury. Comparable mines elsewhere have been transformed into heritage sites and tourist attractions, such as at Monte Amiata in Italy and Idrija in Slovenia. In view of the potential, this study aimed to establish the historical and industrial significance of the Karaburun mercury mining district through detailed research and site survey to form a robust base for a holistic conservation approach. © 2025 Elsevier B.V., All rights reserved.Article Pvc/Pan-immobilized H2TiO3 Adsorbent: a Tailored Titanium-Based Lithium-Ion Sieve for High-Performance Lithium Recovery(Royal Soc Chemistry, 2025) Recepoglu, Yasar Kemal; Ipek, Onur; Yuksel, AsliThe increasing demand for lithium, driven by the rapid development of electric vehicles and energy storage systems, has created a pressing need for efficient and sustainable lithium recovery technologies. Conventional methods often face challenges related to selectivity, environmental impact, and scalability, necessitating the development of alternative materials. In this study, a polyvinyl chloride/polyacrylonitrile (PVC/PAN)-immobilized titanium-based lithium-ion sieve (HTO) was synthesized for lithium recovery from aqueous media, including geothermal brine. The objective was to obtain a selective, reusable, and mechanically stable adsorbent suitable for industrial-scale applications. The synthesized PVC/PAN-HTO composite was characterized by FT-IR, BET, XRD, and SEM techniques. Batch adsorption studies showed that the optimum lithium recovery occurred at pH 12, with efficiencies of 98.7% in model lithium solutions and 91.6% in geothermal water using a 4 g L-1 adsorbent dosage. Adsorption kinetics followed a pseudo-second-order model, and the Langmuir isotherm provided the best fit, indicating monolayer adsorption with a maximum capacity of 5.79 mg g-1. Thermodynamic analysis confirmed that the adsorption process is spontaneous and exothermic. Reusability tests demonstrated stable performance over three adsorption-desorption cycles, confirming the potential of PVC/PAN-HTO for practical lithium extraction applications.