Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 1Bioavailability Assessment of the Novel Gsh-Functionalized Feb Nanoparticles Via Oxidative Stress and Trace Element Metabolism in Vitro: Promising Tools for Biomedical Applications(Springer, 2024) Aydemir, Duygu; Aribuga, Dilara; Hashemkhani, Mahshid; Acar, Havva Yagci; Çağıran, Özge Balcı; Ulusu, Nuriye NurayIron-based magnetic nanoparticles (NPs) have attracted significant attention in biomedical research, particularly for applications such as cancer detection and therapy, targeted drug delivery, magnetic resonance imaging (MRI), and hyperthermia. This study focuses on the synthesis and glutathione (GSH) functionalization of iron boride (FeB) nanoparticles (NPs) for prospective biomedical use. The GSH-functionalized FeB NPs (FeB@GSH) demonstrated ferromagnetic behavior, with a saturation magnetization (Ms) of 45.8 emu/g and low coercivity (Hc = 1000 Oe), indicating desirable magnetic properties for biomedical applications. Transmission electron microscopy (TEM) analysis of the FeB@GSH revealed well-dispersed nanoparticles with diameters smaller than 30 nm. Comprehensive nanotoxicity and biocompatibility assessments were performed using various healthy and cancer cell lines, including 293 T, HeLa, 3T3, MCF7, HCT116, and CFPAC-1. Cytotoxicity assays were conducted on FeB@GSH-treated cells over a dose range of 0-300 mu g/mL during 24-h incubations. Results indicated no significant differences in cell viability between treated and untreated control groups, confirming the biocompatibility of FeB@GSH. Further nanotoxicity evaluations were carried out on 3T3, 293 T, and CFPAC-1 cell lines, focusing on oxidative stress markers and cellular metabolism by measuring antioxidant enzyme activity. Additionally, ion release and mineral metabolism were assessed using inductively coupled plasma mass spectrometry (ICP-MS), revealing no notable variations between the treated and control groups. These findings suggest that FeB@GSH NPs exhibit excellent biocompatibility, making them promising candidates for diverse biomedical applications, including medical imaging, drug delivery systems, and therapeutic interventions.Article Citation - WoS: 14Citation - Scopus: 14Development of Tissue-Engineered Vascular Grafts From Decellularized Parsley Stems(Royal Society of Chemistry, 2023) Çevik, Merve; Dikici, SerkanCardiovascular diseases are mostly associated with narrowing or blockage of blood vessels, and it is the most common cause of death worldwide. The use of vascular grafts is a promising approach to bypass or replace the blocked vessels for long-term treatment. Although autologous arteries or veins are the most preferred tissue sources for vascular bypass, the limited presence and poor quality of autologous vessels necessitate seeking alternative biomaterials. Recently, synthetic grafts have gained attention as an alternative to autologous grafts. However, the high failure rate of synthetic grafts has been reported primarily due to thrombosis, atherosclerosis, intimal hyperplasia, or infection. Thrombosis, the main reason for failure upon implantation, is associated with damage or absence of endothelial cell lining in the vascular graft's luminal surface. To overcome this, tissue-engineered vascular grafts (TEVGs) have come into prominence. Alongside the well-established scaffold manufacturing techniques, decellularized plant-based constructs have recently gained significant importance and are an emerging field in tissue engineering and regenerative medicine. Accordingly, in this study, we demonstrated the fabrication of tubular scaffolds from decellularized parsley stems and recellularized them with human endothelial cells to be used as a potential TEVG. Our results suggested that the native plant DNA was successfully removed, and soft tubular biomaterials were successfully manufactured via the chemical decellularization of the parsley stems. The decellularized parsley stems showed suitable mechanical and biological properties to be used as a TEVG material, and they provided a suitable environment for the culture of human endothelial cells to attach and create a pseudo endothelium prior to implantation. This study is the first one to demonstrate the potential of the parsley stems to be used as a potential TEVG biomaterial. © 2024 The Royal Society of Chemistry.Article Citation - WoS: 8Citation - Scopus: 8Design and Fabrication of Polymer Micro/Nano Composites With Two-Level Mechanical Reinforcing Procedure(Wiley, 2022) Kandemir, Ayşe Çağıl; Dönmez, Fatma; Davut, Kemal; Kaplan Can, HaticeBiocompatible composite production was accomplished by utilizing two-level hierarchical approach for mechanical reinforcement. A well-known commodity polymer; low-density polyethylene (LDPE), which has high-fracture toughness, yet low strength and modulus was used as the main matrix material. As the first step of hierarchy, ductile LDPE was blended with brittle polyvinylpyrrolidone (PVP), which is an eco-friendly, nontoxic and biocompatible polymer. This resulted in slight decrease of strength and drastic reduction of toughness (%70), yet modulus was increased by 78%. As the second level of hierarchy, PVP composites were introduced in LDPE. Nano-scaled Halloysite clay and micro-scaled spherical Silica particles were utilized as additives in the aforementioned PVP composites. The reason for the choice of these particles is that they are nontoxic, low-cost and in the case of Halloysite; abundant in nature. Owing to the implementation of the second level; modulus improvement was further enhanced to 150%, with additional benefits of strength increase up to 17% and less reduction in fracture toughness (minimum 51% reduction). Dynamic mechanical analysis also supported these outcomes that storage modulus of composites are higher than both LDPE and LDPE-PVP blend. The proposed biocompatible composites in the end of this study would be utilized in biomedical applications necessitating mechanical improvements.