Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Conference Object Development of a Force Sensor for Biomechanical Simulations of a Cycling Activity(IEEE, 2022) Karacaoğlu, Bilal; Şahin, Ahmet Mert; Çıklaçandır, Samet; Yılmaz, Mehmet; Mihçin, ŞenayKnowing the forces applied to the pedals during a cycling activity is of great importance in the field of biomechanics when calculating the loads acting on the joints. A load cell-based force sensor was designed for this purpose since the force plate fixed to the floor in gait laboratories cannot be used to measure the reaction forces on the bicycle pedal due to physical constraints. To investigate the accuracy and precision of the force plate, a two-stage experiment, static and dynamic force measurement tests were designed. First, the first static measurements were carried out with standard loads of 1000 g, 1200 g, 1500 g. To understand the behavior of the sensors under dynamic loading, dynamic measurements were conducted while the designed force sensor is attached to the bike pedal while using a commercially available power meter simultaneously to cross-validate the measured forces. Standard loads of 1000 g, 1200 g, and 1500 g were measured as 1020 ± 2 g, 1196 ± 2 g, and 1512 ± 1 g respectively. To assess the agreement between measurements Bland-Altman plot analysis was carried out. The Bland-Altman plots showed that the force platform is appropriate for both measuring static loads and dynamic loads. The collected data via this custom-made, affordable force sensor was successfully fed into the biomechanical modeling software to calculate the joint reaction forces.Article Citation - WoS: 2Citation - Scopus: 6Towards Integration of the Finite Element Modeling Technique Into Biomedical Engineering Education(World Scientific Publishing, 2022) Mihçin, Şenay; Çıklaçandır, SametBiomedical engineering (BME) is a multidisciplinary field, resulting in a heavy course load from different fields. We hypothesize that the engineering curriculum be tailored according to the requirements of the BME profession. In this study, we focus on the teaching of the finite element modeling (FEM) technique by redesigning the course to address the needs of the BME profession by some custom-made changes to meet the unmet needs. After the completion of the course, evaluation methods of the students were analyzed and detailed over a survey providing feedback from the students. The surveys were related to the teaching the theory of FEM, the laboratory sessions, and the project sessions. The survey results were evaluated using statistical methods. The Pearson correlation coefficient showed a linear agreement between theoretical and practical sessions indicating efficient blending of skills because of the custom-made changes. The survey analysis showed that the students were in favour of the changes, allowing them to be more resourceful and confident with their skills. The positive results indicate a positive attitude among the students towards their profession. As the course design addresses the needs of the profession allowing students to fit in better, the students might follow their own profession after graduation. A wider follow-up study might be planned next to compare the results between who received tailor-designed courses and those who did not.Article Citation - WoS: 3Citation - Scopus: 4Applicability of Low-Intensity Vibrations as a Regulatory Factor on Stem and Progenitor Cell Populations(Bentham Science Publishers, 2020) Baskan, Öznur; Karadaş, Özge; Meşe, Gülistan; Özçivici, EnginPersistent and transient mechanical loads can act as biological signals on all levels of an organism. It is therefore not surprising that most cell types can sense and respond to mechanical loads, similar to their interaction with biochemical and electrical signals. The presence or absence of mechanical forces can be an important determinant of form, function and health of many tissue types. Along with naturally occurring mechanical loads, it is possible to manipulate and apply external physical loads on tissues in biomedical sciences, either for prevention or treatment of catabolism related to many factors, including aging, paralysis, sedentary lifestyles and spaceflight. Mechanical loads consist of many components in their applied signal form such as magnitude, frequency, duration and intervals. Even though high magnitude mechanical loads with low frequencies (e.g. running or weight lifting) induce anabolism in musculoskeletal tissues, their applicability as anabolic agents is limited because of the required compliance and physical health of the target population. On the other hand, it is possible to use low magnitude and high frequency (e.g. in a vibratory form) mechanical loads for anabolism as well. Cells, including stem cells of the musculoskeletal tissue, are sensitive to high frequency, low-intensity mechanical signals. This sensitivity can be utilized not only for the targeted treatment of tissues, but also for stem cell expansion, differentiation and biomaterial interaction in tissue engineering applications. In this review, we reported recent advances in the application of low-intensity vibrations on stem and progenitor cell populations. Modulation of cellular behavior with low-intensity vibrations as an alternative or complementary factor to biochemical and scaffold induced signals may represent an increase of capabilities in studies related to tissue engineering.Article Citation - WoS: 21Citation - Scopus: 26Computerized Method for Nonrigid Mr-To Breast-Image Registration(Elsevier Ltd., 2010) Ünlü, Mehmet Zübeyir; Krol, A.; Magri, A.; Mandel, J. A.; Lee, W.; Baum, K. G.; Lipson, E. D.; Coman, I. L.; Feiglin, D. H.We have developed and tested a new simple computerized finite element method (FEM) approach to MR-to-PET nonrigid breast-image registration. The method requires five-nine fiducial skin markers (FSMs) visible in MRI and PET that need to be located in the same spots on the breast and two on the flanks during both scans. Patients need to be similarly positioned prone during MRI and PET scans. This is accomplished by means of a low gamma-ray attenuation breast coil replica used as the breast support during the PET scan. We demonstrate that, under such conditions, the observed FSM displacement vectors between MR and PET images, distributed piecewise linearly over the breast volume, produce a deformed FEM mesh that reasonably approximates nonrigid deformation of the breast tissue between the MRI and PET scans. This method, which does not require a biomechanical breast tissue model, is robust and fast. Contrary to other approaches utilizing voxel intensity-based similarity measures or surface matching, our method works for matching MR with pure molecular images (i.e. PET or SPECT only). Our method does not require a good initialization and would not be trapped by local minima during registration process. All processing including FSMs detection and matching, and mesh generation can be fully automated. We tested our method on MR and PET breast images acquired for 15 subjects. The procedure yielded good quality images with an average target registration error below 4 mm (i.e. well below PET spatial resolution of 6-7 mm). Based on the results obtained for 15 subjects studied to date, we conclude that this is a very fast and a well-performing method for MR-to-PET breast-image nonrigid registration. Therefore, it is a promising approach in clinical practice. This method can be easily applied to nonrigid registration of MRI or CT of any type of soft-tissue images to their molecular counterparts such as obtained using PET and SPECT. © 2009 Elsevier Ltd. All rights reserved.