Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 2Citation - Scopus: 2A Novel Phenalenone-Based Probe for Dual-Mode Hydrazine Detection(Elsevier Inc., 2025) Saygili, Ecem; Kibris, Erman; Gelen, Sultan Sacide; Eldem, Asli; Odaci, Dilek; Ucuncu, MuhammedDespite its toxic and carcinogenic nature, hydrazine (N2H4) remains a crucial compound in environmental and industrial applications. Its associated risks demand effective monitoring; however, conventional detection methods often fall short in sensitivity and accuracy, highlighting the need for innovative approaches. This study presents a novel turn-on probe based on phenalenone-phthalimide scaffold, 2-(1-oxo-1H-phenalen-6-yl)isoindoline-1,3-dione (6-AP-PI), specifically designed for N2H4 detection, offering a novel approach by combining fluorescence and electrochemical signals, thereby significantly enhancing detection performance. 6-AP-PI exhibits an exceptional selectivity and sensitivity toward N2H4 both in solution and cellular media, providing rapid signal enhancement (<1 min) and a low limit of detection (490 nM). Overall, this dual-mode design effectively addresses the limitations of traditional methods, enhancing both sensitivity and selectivity, positioning the 6-AP-PI probe as a promising tool for future health, safety, and environmental protection applications.Article Citation - WoS: 625Citation - Scopus: 698Flow Cytometry: Basic Principles and Applications(Taylor and Francis Ltd., 2017) Adan, Aysun; Alizada, Günel; Kiraz, Yağmur; Baran, Yusuf; Nalbant, AytenFlow cytometry is a sophisticated instrument measuring multiple physical characteristics of a single cell such as size and granularity simultaneously as the cell flows in suspension through a measuring device. Its working depends on the light scattering features of the cells under investigation, which may be derived from dyes or monoclonal antibodies targeting either extracellular molecules located on the surface or intracellular molecules inside the cell. This approach makes flow cytometry a powerful tool for detailed analysis of complex populations in a short period of time. This review covers the general principles and selected applications of flow cytometry such as immunophenotyping of peripheral blood cells, analysis of apoptosis and detection of cytokines. Additionally, this report provides a basic understanding of flow cytometry technology essential for all users as well as the methods used to analyze and interpret the data. Moreover, recent progresses in flow cytometry have been discussed in order to give an opinion about the future importance of this technology.Article Citation - WoS: 80Citation - Scopus: 82Electrophilic Cyanate as a Recognition Motif for Reactive Sulfur Species: Selective Fluorescence Detection of H2s(American Chemical Society, 2016) Karakuş, Erman; Üçüncü, Muhammed; Emrullahoğlu, MustafaAn ESIPT-based fluorescent dye, 3-hydroxyflavone, is chemically masked with an electrophilic cyanate motif in order to construct a fluorescent probe for cellular sulfur species. This novel probe structure, displays an extremely fast, highly sensitive and selective "turn-on" type fluorescent response toward H2S. We have also documented its utility for imaging of H2S in the living cells.