Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Subject: search.filters.subject.Phthalocyanine

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  • Article
    Citation - WoS: 3
    Citation - Scopus: 2
    Design and Evaluation of Novel Poly (Vinyl Alcohol)-Based Electrospun Nanofibers Bearing Quaternized Zinc Phthalocyanine with Improved Antibacterial Efficiency
    (Elsevier Sci Ltd, 2025) Yavuz, Ozgur; Cakir, Neslihan Turhan; Alcay, Yusuf; Kadi, Ilayda Hizir; Kahveci, Muhammet U.; Yilmaz, Ismail; Altinkok, Cagatay
    Electrospinning of macrocyclic compounds offers a versatile route to functional nanofibers for biomedical applications. However, the small molecular size and tendency to aggregate of such compounds often preclude their direct processing. Herein, we report the fabrication of poly(vinyl alcohol) (PVA) nanofibers uniformly embedded with a dimethylaminophenyl-functionalized, quaternized zinc phthalocyanine derivative (Q-DMAPZnPc) via a straightforward aqueous electrospinning process. Successful incorporation of Q-DMAPZnPc into the PVA matrix was confirmed by FT-IR and 1H NMR spectroscopies. SEM revealed bead-free fibers with average diameters decreasing from 152 +/- 20 nm to 110 +/- 23 nm as the Q-DMAPZnPc loading increased. Water contact angle, thermogravimetric, and differential scanning calorimetry analyses demonstrated that both hydrophilicity and thermal stability of the fibers improved with higher Q-DMAPZnPc content. The singlet oxygen quantum yield (Phi Delta) of the PVA-Q-DMAPZnPc (5 wt %) was measured as 0.35. Importantly, quaternization endowed the fibers with potent antibacterial activity: under visible-light irradiation, PVA-Q-DMAPZnPc mats achieved significant log-reduction against both Gram-negative (Escherichia coli, Salmonella typhimurium) and Gram-positive (Staphylococcus aureus, Bacillus cereus) pathogens, markedly outperforming neat PVA controls. These findings highlight the promise of Q-DMAPZnPc-loaded PVA nanofibers as light-activated antimicrobial platforms for next-generation therapeutic and protective materials.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 5
    Development of Ab3-Type Novel Phthalocyanine and Porphyrin Photosensitizers Conjugated With Triphenylphosphonium for Higher Photodynamic Efficacy
    (American Chemical Society, 2022) Albakour, Mohamad; Önal, Emel; Tüncel, Özge; Erdoğan, İpek; Gümüşgöz Çelik, Gizem; Küçük, Tuǧba; Akgül, Bünyamin; Gürek, Ayşe Gül; Özçelik, Serdar
    There are a number of lipophilic cations that can be chosen; the triphenylphosphonium (TPP) ion is particularly unique for mitochondrion targeting, mainly due to its simplicity in structure and ease to be linked to the target molecules. In this work, mitochondrion-targeted AB3-type novel phthalocyanine and porphyrin photosensitizers (PSs) were synthesized and their photophysical photochemical properties were defined. Fluorescence quantum yields (φF) are 0.009, 0.14, 0.13, and 0.13, and the singlet-oxygen quantum yields (φΔ) are 0.27, 0.75, 0.57, and 0.58 for LuPcPox(OAc), AB3TPP-Pc, AB3TPP-Por-C4, and AB3TPP-Por-C6, respectively. To evaluate the photodynamic efficacy of the TPP-conjugated PS cell viabilities of A549 and BEAS-2B lung cells were comparatively measured and IC-50 values were determined. AB3TPP-Por-C4, AB3TPP-Por-C6, and AB3TPP-Pc compounds compared to the reference molecules ZnPc and H2TPP were found to be highly cytotoxic (sub-micromolar concentration) under the light. LuPcPox(OAc) is the most effective molecule regarding cell killing (the activity). The cell killing of the TPP-conjugated porphyrin derivatives exhibits a similar response compared to LuPcPox(OAc) when the light absorbing factor of the PS is normalized at 660 nm: TPP-conjugated porphyrins absorb less light (lower extinction coefficient) but produce more radical species (higher singlet-oxygen quantum yield) and therefore effectively kill the cells. The singlet oxygen-producing capacity of AB3TPP-Pc is almost 3 times higher compared to LuPcPox(OAc) and 50% more efficient with respect to ZnPc, suggesting that TPP-conjugated phthalocyanine may serve as a good photosensitizer for photodynamic therapy (PDT). The high singlet oxygen generation capacity of these novel TPP-conjugated porphyrin and phthalocyanine PS suggests that they might be useful for PDT requiring lower photosensitizer concentration and reduced energy deposited through less light exposure.