Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Subject: search.filters.subject.PolycaprolactoneWoS Q: search.filters.wosQuartile.Q1

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  • Article
    Citation - WoS: 27
    Citation - Scopus: 27
    In Vivo Bone Regeneration Capacity of Multiscale Porous Polycaprolactone-Based High Internal Phase Emulsion (polyhipe) Scaffolds in a Rat Calvarial Defect Model
    (American Chemical Society, 2023) Aldemir Dikici, Betül; Chen, Min-Chia; Dikici, Serkan; Chiu, Hsien-Chung; Claeyssens, Frederik
    Globally, one of the most common tissue transplantationproceduresis bone grafting. Lately, we have reported the development of polymerizedhigh internal phase emulsions (PolyHIPEs) made of photocurable polycaprolactone(4PCLMA) and shown their potential to be used as bone tissue engineeringscaffolds in vitro. However, it is essential to evaluatethe in vivo performance of these scaffolds to investigatetheir potential in a clinically more relevant manner. Therefore, inthis study, we aimed to compare in vivo performancesof macroporous (fabricated using stereolithography), microporous (fabricatedusing emulsion templating), and multiscale porous (fabricated usingemulsion templating and perforation) scaffolds made of 4PCLMA. Also,3D-printed macroporous scaffolds (fabricated using fused depositionmodeling) made of thermoplastic polycaprolactone were used as a control.Scaffolds were implanted into a critical-sized calvarial defect, animalswere sacrificed 4 or 8 weeks after implantation, and the new boneformation was assessed by micro-computed tomography, dental radiography,and histology. Multiscale porous scaffolds that include both micro-and macropores resulted in higher bone regeneration in the defectarea compared to only macroporous or only microporous scaffolds. Whenone-grade porous scaffolds were compared, microporous scaffolds showedbetter performance than macroporous scaffolds in terms of mineralizedbone volume and tissue regeneration. Micro-CT results revealed thatwhile bone volume/tissue volume (Bv/Tv) values were 8 and 17% at weeks4 and 8 for macroporous scaffolds, they were significantly higherfor microporous scaffolds, with values of 26 and 33%, respectively.Taken together, the results reported in this study showed the potentialapplication of multiscale PolyHIPE scaffolds, in particular, as apromising material for bone regeneration.
  • Article
    Citation - WoS: 18
    Citation - Scopus: 21
    Crystallization Kinetics and Affecting Parameters on Polycaprolactone Composites With Inorganic and Organic Additives
    (John Wiley and Sons Inc., 2015) Cesur, Serap; Alp, Burcu; Küçükgöksel, Yelda; Kahraman, Tansel; Balköse, Devrim
    The isothermal crystallization and mechanical behavior of biodegradable polycaprolactone (PCL) composites with organic (oleic acid and glycerol monooleate) and inorganic (zinc oxide, organoclay, and hydroxy apatite) additives used alone or simultaneously were investigated. The effect of all additives on the degree of crystallinity percentage (DOC%), isothermal crystallization kinetics parameters, and mechanical test results of PCL composites was studied. The PCL composite films were prepared by solvent casting by using dichloromethane as the solvent. The films were characterized by X-ray diffraction, differential scanning calorimetry (DSC), and tensile tests. DSC of the first melting and X-ray diffraction DOC% results (for composites by solvent casting) are compatible. The values by DSC of the second melting (for composites by extrusion method) are lower. Organoclay gives the highest crystallinity among the other inorganic additives used. Small amounts of inorganic additives act as a nucleating agent and increase the crystallinity; the higher amounts decrease. The organic additives act as the plasticizer. When used alone, it lowers the crystallinity, but when used with inorganic additives, it improves the dispersion of inorganic particles in the polymer matrix. The isothermal crystallization kinetics parameters by Avrami analysis showed that crystallization was controlled by nucleation and the crystals had spherical structure. The nucleation type changed between thermal and athermal nucleation. The Pukanzky model interaction parameter B indicated that the organic additives improved the dispersion of inorganic particles in the polymer matrix. Statistically significant, eight correlations (F>6) were obtained for the crystallinity, crystallization parameters, Young's modulus, and tensile strength as a function of concentration of additives.