Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Now showing 1 - 10 of 23
  • Article
    Design Strategies to Optimize Polymeric Vectors for mRNA Delivery
    (Taylor and Francis Ltd., 2025) Turhan, Z.Y.; Savaş, M.; Alakbarov, A.; Bulmus, V.
    mRNA holds great promise for preventing and treating a variety of diseases, from infectious diseases to diverse cancers, owing to its transient expression, lack of genomic integration, and scalable production. Among non-viral vectors, polymeric carriers are attractive due to their synthetic versatility and stability, which allow for precise tuning for efficient mRNA delivery. Their scalability further supports the applicability of polymeric vectors. Studies have addressed the room for improvement in polymeric systems for mRNA delivery and have adapted varying approaches depending on the type of polymeric structure, including but not limited to PEGylation, hydrophobic modification, and incorporation of responsive or targeting moieties. This review summarizes advances in polymeric vectors for mRNA delivery and highlights how distinct structural modifications influence toxicity, mRNA transfection efficiency, biodistribution, intracellular trafficking and immune activation, providing a framework for the rational design of next-generation polymeric vectors that can fully realize the clinical potential of mRNA therapeutics. © 2025 Taylor & Francis Group, LLC.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Hybrid Preceramic Aerogels for Oil and Solvent Cleanup
    (Wiley-v C H verlag Gmbh, 2025) Icin, Oyku; Vakifahmetoglu, Cekdar
    This study presents the first synthesis and characterization of monolithic hybrid preceramic aerogels using distinct drying techniques: ambient pressure (ambigels) and CO2 supercritical drying. Polymeric ambi/aerogels, derived from polyhydromethlysiloxane (PHMS) and divinylbenzene (DVB), are processed at 200 degrees C, while hybrid ceramic-polymer (ceramer) is produced through pyrolysis at 600 degrees C. Despite variations in drying methods, polymer and ceramer ambi/aerogels exhibit comparable microstructural characteristics, bulk density, pore size and volume, and specific surface area (542-841 m(2) g(-1)). Polymeric and ceramer ambigel with 90 vol% total porosity yield a compressive strength, reaching 2.5 MPa, demonstrating a low thermal conductivity of 0.046 W m-1 K-1. Sorption tests are conducted using oil and organic solvents in aqueous media to benefit their high hydrophobicity (112 degrees < theta < 142 degrees). Aerogels exhibit high sorption capacities: 13.17 g g(-1) for sesame oil, 11.74 g g(-1) for toluene, and 9.19 g g(-1) for n-hexane. The sorption rate for the oil is nearly 10 times slower than that for toluene and n-hexane. Regarding regeneration and reusability, polymer and ceramer aerogels show consistent sorption properties cycles tested for n-hexane and toluene.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Roadmap on Multifunctional Materials for Drug Delivery
    (IOP Publishing, 2024) Nottelet, Benjamin; Buwalda, Sytze; van Nostrum, Cornelus F.; Zhao, Xiaofei; Deng, Chao; Zhong, Zhiyuan; Cheah, Ernest; Kehr, Nermin Seda
    This Roadmap on drug delivery aims to cover some of the most recent advances in the field of materials for drug delivery systems (DDSs) and emphasizes the role that multifunctional materials play in advancing the performance of modern DDSs in the context of the most current challenges presented. The Roadmap is comprised of multiple sections, each of which introduces the status of the field, the current and future challenges faced, and a perspective of the required advances necessary for biomaterial science to tackle these challenges. It is our hope that this collective vision will contribute to the initiation of conversation and collaboration across all areas of multifunctional materials for DDSs. We stress that this article is not meant to be a fully comprehensive review but rather an up-to-date snapshot of different areas of research, with a minimal number of references that focus upon the very latest research developments.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Epoxy Matrix Nano Composites: Modulus, Strength and Ductility Enhancement Through Auxeticity of Α-Cristobalite Filler
    (Elsevier, 2023) Güden, Mustafa; Ülker, Sevkan; Movahedi, Nima
    The negative Poisson's ratio (NPR) nano-size ?-Cristobalite particle/epoxy composites were prepared and tensile tested. The elastic modulus and strength of the composites were improved as the particle volume fraction increased from 0 to 0.02. Unlike the conventional particle reinforced composites, the fracture strain increased with the nano ?-Cristobalite addition, an effect which was ascribed to the intrinsic NPR behavior of the filler. © 2023 Elsevier B.V.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Stabilization of Calcareous Subgrade Soils With Polyelectrolytes: Mechanisms and Mechanical Properties
    (Taylor & Francis, 2023) Huang, Jianxin; Kogbara, Reginald; Mohomad, Yosef; Kogbara, Reginald B.; Masad, Eyad; Sukhishvili, Svetlana; Little, Dallas
    Organic polyelectrolytes, i.e. anionic poly(sodium 4-styrenesulphonate) (PSS), cationic poly(diallyldimethylammonium chloride) (PDADMAC) and their polyelectrolyte complexes (PECs) were evaluated for stabilisation of calcareous sandy subgrade soil. This paper investigated the effects of polymer type, surface charge type of PEC, concentrations of PEC solutions and dosages of polymer solutions added to the soil on improvement of soil mechanical properties. We found that anionic polymers, for both PECs and individual polyelectrolytes, were superior to their cationic counterparts in improving soil strength. Besides, the constituent polyelectrolytes, PSS and PDADMAC, worked better than their PECs for the specific soil investigated. The strength of polymer-treated soils was also found to increase with the increase in dosages of the polymer solutions as well as curing periods. Furthermore, polymer-treated soil specimens exhibited significant toughness improvement, which was higher than cement-treated samples. Scanning electron microscopy images revealed the abundance of long palygorskite fibres covering the surfaces of larger calcite and dolomite particles and linking surrounding aggregates after adding polymers. This observation suggests the interconnection of palygorskite fibres and their linking networks between and among coarse aggregates as the likely mechanism of polymer stabilisation of the soil studied.
  • Article
    Citation - WoS: 9
    Citation - Scopus: 8
    Development of a New Electrochemical Sensor Based on Molecularly Imprinted Biopolymer for Determination of 4,4'-methylene Diphenyl Diamine
    (MDPI, 2023) Ghaani, Masoud; Büyüktaş, Duygu; Carullo, Daniele; Farris, Stefano
    A new molecularly imprinted electrochemical sensor was proposed to determine 4,4' methylene diphenyl diamine (MDA) using molecularly imprinted polymer-multiwalled carbon nanotubes modified glassy carbon electrode (MIP/MWCNTs/GCE). GCE was coated by MWCNTs (MWCNTs/GCE) because of their antifouling qualities and in order to improve the sensor sensitivity. To make the whole sensor, a polymeric film made up of chitosan nanoparticles was electrodeposited by the cyclic voltammetry method on the surface of MWCNTs/GCE in the presence of MDA as a template. Different parameters such as scan cycles, elution time, incubation time, molar ratio of template molecules to functional monomers, and pH were optimized to increase the performance of the MIP sensor. With a detection limit of 15 nM, a linear response to MDA was seen in the concentration range of 0.5-100 mu M. The imprinting factor (IF) of the proposed sensor was also calculated at around 3.66, demonstrating the extremely high recognition performance of a MIP/MWCNT-modified electrode. Moreover, the sensor exhibited good reproducibility and selectivity. Finally, the proposed sensor was efficiently used to determine MDA in real samples with satisfactory recoveries ranging from 94.10% to 106.76%.
  • Book
    Citation - Scopus: 5
    Aluminium-Coated Polymer Films as Infrared Light Shields for Food Packing
    (Apple Academic Press, 2014) Hamrang, Abbas; Balköse, Devrim; Zaikov, Gennadij Efremovich; Haghi, A. K.
    This book covers a broad range of polymeric materials and provides industry professionals and researchers in polymer science and technology with a single, comprehensive book summarizing all aspects involved in the functional materials production chain. This volume presents the latest developments and trends in advanced polymer materials and structures. It discusses the developments of advanced polymers and respective tools to characterize and predict the material properties and behavior. This book has an important role in advancing polymer materials in macro and nanoscale. Its aim is to provide original, theoretical, and important experimental results that use non-routine methodologies. It also includes chapters on novel applications of more familiar experimental techniques and analyses of composite problems that indicate the need for new experimental approaches. This new book: • Provides a collection of articles that highlight some important areas of current interest in key polymeric materials and technology. • Gives an up-to-date and thorough exposition of the present state of the art of key polymeric materials and technology. • Describes the types of techniques now available to the engineers and technicians and discusses their capabilities, limitations, and applications. • Provides a balance between materials science and chemical aspects, basic and applied research. • Focuses on topics with more advanced methods. • Emphasizes precise mathematical development and actual experimental details. • Explains modification methods for changing of different materials properties. © 2020 Elsevier B.V., All rights reserved.
  • Article
    Citation - WoS: 10
    Citation - Scopus: 12
    Transparent block copolymer thin films for protection of optical elements via chemical vapor deposition
    (Elsevier Ltd, 2018) Karabıyık, Merve; Ebil, Özgenç
    In this study, glycidyl methacrylate and 1H, 1H, 2H, 2H-perfluorodecyl acrylate copolymer p(GMA-co-PFDA) thin-films fabricated via Initiated Chemical Vapor Deposition (iCVD) were investigated as protective coatings on optical BK7 glass substrates and commercial optical filters. Durability tests based on military standards MIL-F-48616 and MIL-C-48497A were performed to evaluate performance of coatings for the protection of surfaces of optical elements. Cross-linked p(GMA-co-PFDA) copolymer coatings successfully passed all durability tests showing excellent mechanical properties and protection against humidity, salt water, swelling in water, and resistance to organic solvents while providing excellent adhesion to substrate. iCVD process enabled fine tuning of film morphology, mechanical properties and hydrophobicity by controlling the process parameters. Fabricated films were hydrophobic and highly transparent (>98%) in the wavelength range from 300 nm to 1000 nm. Optical transmittance measurements before and after coating process proved that while providing chemical and physical protection, p(GMA-co-PFDA) copolymer thin-films do not cause any detectable change in optical performance of commercial narrow band and wide band filters.
  • Article
    Citation - WoS: 23
    Citation - Scopus: 27
    Novel Poss Reinforced Chitosan Composite Membranes for Guided Bone Tissue Regeneration
    (Springer Verlag, 2018) Tamburacı, Sedef; Tıhmınlıoğlu, Funda
    In this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS® nanofiller to the chitosan matrix increased the surface roughness, protein adsorption and swelling capacity of membranes. The addition of POSS enhanced significantly the ultimate tensile strength and strain at break of the composite membranes up to 3 wt% POSS loaded samples. An increase of about 76% in tensile strength and of strain at break 1.28% was achieved for 3 wt% POSS loaded nanocomposite membranes compared with chitosan membranes. The presence of POSS filler into polymer matrix increased the plasma protein adsorption on the surface. Maximum protein capacity and swelling was obtained for 10 wt% loaded samples. High cell viability results were obtained with indirect extraction of chitosan/POSS composites. Besides, cell proliferation and ALP activity results showed that POSS incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. This novel composite membranes with tunable properties could be considered as a potential candidate for guided bone regeneration applications
  • Book Part
    Citation - Scopus: 1
    Mass Spectroscopy in Polymer Research
    (John Wiley and Sons Inc., 2012) Hacaloğlu, Jale; Yalçın, Talat
    Mass spectrometers are currently available in numerous confi gurations with various ionization techniques and mass analyzers. For a specifi c polymer sample, an optimal choice should be done depending on the information sought. In practice, no single mass spectrometric technique can provide all necessary information for structural, compositional, and thermal and oxidative degradation characteristics of polymeric samples. The analyzer used determines the limits of the sensitivity and resolution and the mass range, whereas the type of ionization source specifi es the information that can be gained.