Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1From Chemistry to Clinic: Polysaccharide-Bioceramic Composites for Tissue Engineering Applications(Mary Ann Liebert, Inc, 2025) Yakubogullari, Nilgun; Yilmaz-Dagdeviren, Hilal Deniz; Arslan-Yildiz, AhuComposite scaffolds combining polysaccharides and bioceramics represent next-generation scaffolds extensively investigated in tissue engineering (TE) and biomedical applications. Polysaccharides such as chitosan, hyaluronic acid, and pectin mimic the extracellular matrix components with their tunable physicochemical properties, enabling a favorable microenvironment for cell adhesion, proliferation, and cell-matrix interactions. On the other hand, bioceramics, including calcium phosphate, hydroxyapatite, and bioactive glasses, enhance the mechanical properties of the material and offer structural integrity and osteoconductive properties. While they have generally been preferred to be used in bone TE and dental applications, various studies have also demonstrated their potential in cartilage regeneration, wound healing, and broader biomedical applications. Recent advancements in material design and scaffold fabrication techniques, particularly 3D printing and electrospinning, have provided precise engineering of materials and fabrication of scaffolds for desirable mechanical properties and biological performance. These innovations foster the development of patient-specific scaffolds, thereby paving the way for applications in personalized medicine. This review critically summarizes alternative polysaccharides, bioceramics, and composite materials used in TE and biomedical applications. It also highlights advanced fabrication strategies and finally explores the translational potential of these biocomposites. By integrating emerging technologies, this review aims to provide alternative and sustainable materials for the development of next-generation scaffolds that meet clinical needs.Impact Statement This study introduces polysaccharide-bioceramic composites with enhanced mechanical and biological properties for tissue engineering. Beyond bone and dental repair, their applications increasingly extend to wound healing, cartilage, cardiac, and muscle regeneration with drug delivery, angiogenesis, and neurogenesis. By mimicking the native extracellular matrix, these composites support cell growth and tissue regeneration, offering a versatile platform for advanced regenerative therapies.Article Citation - WoS: 2Citation - Scopus: 3Unlocking the Biological Potential of Emulsion-Templated Matrices Through Surface Engineering for Biomedical Applications(Elsevier Sci Ltd, 2025) Sert, Emircan; Ozmen, Ece; Owen, Robert; Dikici, Betul AldemirEmulsion templating is a highly advantageous route for the fabrication of porous materials, enabling the development of matrices with high porosity, high interconnectivity, and precise morphological control. Synthetic polymers are most widely used in the fabrication of emulsion-templated tissue engineering scaffolds due to their superior mechanical strength, ease of fabrication, control over polymer properties, and batch-to-batch stability. The biological response is strongly associated with the surface properties of the biomaterials; however, scaffolds constructed from synthetic polymers often lack cell recognition sites and exhibit limited bioactivity. Thus, synthetic polymer-based porous matrices commonly require surface post-modification to improve cell adhesion, proliferation, migration, gene expression, and differentiation processes. To date, extensive work has been carried out investigating surface modification of scaffolds fabricated via traditional scaffold fabrication techniques. Still, studies addressing the post-modification of emulsion-templated matrices are comparatively limited despite an exponential increase in the number of publications on emulsion templating for tissue engineering in recent years. This review will first examine the fundamentals of emulsion templating, then describe cell adhesion and the characteristics of scaffolds that influence cell-material interactions. It will then provide a comprehensive analysis of surface modification techniques and recent advancements in surface-modified emulsion-templated matrices for tissue engineering applications. Finally, we address the challenges and future directions in this rapidly evolving field. We anticipate that this comprehensive literature review will present the current state-of-the-art and serve as a valuable roadmap for researchers seeking to enhance the biological performance of their emulsion-templated scaffolds through surface modifications. Such scaffold optimisation strategies not only improve cell-material interactions but also hold translational potential for advancing human healthcare through more effective regenerative therapies.Article Citation - WoS: 4Citation - Scopus: 4Surface Modification Via Alkali Treatment and Its Effect on the Physicochemical and Biological Properties of Emulsion Templated Scaffolds(Elsevier Sci Ltd, 2025) Kocagoz, Mehmet; Tihminlioglu, Funda; Dikici, Betul AldemirEmulsion templating is an advantageous scaffold fabrication technique that provides high interconnectivity, high porosity, and control of the scaffold architecture. Polymerised emulsions with an internal phase ratio greater than 74 % are named Polymerised High Internal Phase Emulsions (PolyHIPEs). Polycaprolactone (PCL) is a synthetic, biodegradable, and biocompatible polymer widely used in tissue engineering, but the material-cell interaction of PCL-based biomaterials has been found to be limited due to the material's high hydrophobicity. This study aims to develop emulsion-templated polycaprolactone tetramethacrylate (4PCLMA)-based scaffolds and improve their biological performance using an alkaline surface modification method. For this purpose, 4PCLMA was successfully synthesised, and highly porous scaffolds were developed. PolyHIPEs were incubated in three different sodium hydroxide (NaOH) concentrations for three different incubation times. Chemical, morphological, mechanical characterisation, mass loss, water absorption capacity, water contact angle, Brunauer-Emmett-Teller analyses and biological investigations were conducted on NaOH-treated scaffolds in comparison with the control. The chemical changes induced by NaOH treatment in PolyHIPEs were confirmed by Fourier-transform infrared spectroscopy. NaOH treatment increased the water absorption capacity, hydrophilicity, surface area, and protein adsorption but decreased the weight and mechanical strength of the scaffolds. In vitro results showed that NaOH treatment did not cause cytotoxicity in L929 cells and positively affected the cell adhesion and proliferation behaviour of Saos-2 cells. This study suggests surface modification of biodegradable synthetic polymer-based PolyHIPEs by NaOH treatment as a simple, scalable and cost-effective approach to enhance cell-material interactions of the material without causing a significant change in the overall morphology, contributing to the advancement of next-generation healthcare technologies.Article Citation - WoS: 5Citation - Scopus: 6Hydrocolloids for Tissue Engineering and 3d Bioprinting(World Scientific Publ Co Pte Ltd, 2024) Yildirim-Semerci, Ozum; Onbas, Rabia; Bilginer-Kartal, Rumeysa; Arslan-Yildiz, AhuHydrocolloids, derived from plants, marine, and microbial sources, have become research favorites due to their unique properties. This article provides an overview of the extraction methods, from chemical to enzymatic, to obtain hydrocolloids. Distinctive properties of hydrocolloids, such as high swelling capacity, tunable features, and rapid gelation ability, have gained significant attention recently and have started to be used in tissue engineering and 3D bioprinting. Hydrocolloids will play substantial roles in advancing biomedical products and contributing to improving human health.