Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Subject: search.filters.subject.Tissue engineeringWoS Q: search.filters.wosQuartile.N/A

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Now showing 1 - 5 of 5
  • Book Part
    Citation - Scopus: 2
    Bioprinting of Hydrogels for Tissue Engineering and Drug Screening Applications
    (Elsevier, 2022) Özmen, Ece; Yıldırım, Özüm; Arslan Yıldız, Ahu
    In tissue engineering, the 3-dimensional (3D) bioprinting method that enables the production of 3D structures by combining bioinks and cells has become one of the most promising technique. Over the last few years, 3D cell culture models gained importance in the development of disease model and drug development studies. The successful production of the 3D structures by 3D bioprinting mostly depends on the properties of the bioink to be used. Hydrogels, which are natural or synthetic polymers, are generally preferred as bioink materials with their high swelling ability, biocompatibility, biodegradability, and easy gelation ability. The convenience of hydrogels for varied bioprinting applications make them proper bioink materials for bioprinting of artificial tissues, tumor models, and tissue grafts. Bioprinting of functional tissues is successfully performed for years, and hydrogels are utilized as bioink in bone, vascular, neural, cartilage, cardiac, skin tissue engineering, and drug screening. In this chapter, bioprinting methodology, bioinks, hydrogel bioinks, and their applications are discussed in detail. © 2023 Elsevier Inc. All rights reserved.
  • Book Part
    Citation - Scopus: 3
    Tissue Engineering Applications of Marine-Based Materials
    (Springer, 2022) Polat, Hürriyet; Zeybek, Nuket; Polat, Mehmet
    Tissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
  • Conference Object
    Citation - WoS: 1
    Citation - Scopus: 1
    Biomimetic Peptide-Conjugated Membranes for Developing an Artificial Cornea
    (IEEE, 2022) Sunal, Gülşah; Pulat, Günnur; Akgün, İsmail Hakkı; Güven, Sinan; Yıldız, Ümit Hakan; Karaman, Ozan; Horzum, Nesrin
    The corneal endothelium is composed of a single layer of specialized endothelial cells, protecting, and nourishing the inner surface of the cornea. Corneal endothelial cells do not proliferate after birth and their number decrease with age. Trauma, inflammation, or surgical intervention can cause cell loss. When damage is extensive and the density of corneal endothelial cells decreases to a critical level, it results in corneal edema and vision loss. Besides them, when corneal endothelium has irreversible damage, the only treatment way is corneal transplantation. But there are some drawbacks such as finding donors, immune reactions, and the number of patients waiting on the transplantation lists for years. Tissue engineering approaches can provide promising alternatives for the regeneration of corneal endothelium tissue. Peptides can be used to modify and functionalize the scaffolds, allowing for the production of bioactive and biomimetic surfaces. Peptide-modified scaffold surfaces might direct and enhance the behaviors of cells. In this study, the aim was to functionalize the polycaprolactone (PCL) membranes with tissue-specific peptides and to characterize the peptide-conjugated membranes by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray Photoelectron Spectroscopy (XPS) analysis. The synthesized peptides were successfully conjugated on the PCL biomembranes.
  • Conference Object
    Üç Boyutlu Hücre Kültürü için Polimer Esaslı Ekstrasellüler Matriks Mimetiği
    (Institute of Electrical and Electronics Engineers Inc., 2017) Türker, Esra; Yıldız, Ümit Hakan; Arslan Yıldız, Ahu
    Elektro-eğirme metodu gelişmiş üretim teknolojilerindendir ve biyomedikal uygulamalarında yaygın olarak kullanılmaktadır. Özellikle doku mühendisliğinde amaç, çalışılacak doku üzerine doğal veya sentetik destek materyali (iskele) üreterek hücrenin uyum sağlayabileceği bir ortam oluşturmaktır. Bu projenin amacı üç boyutlu (3D) hücre kültürü çalışmaları için elektro-eğirme-metodu ile poli(L-laktik-co-epsilon-kaprolakton) (PLLCL) kullanılarak iskele üretilmesidir. Homojen lifler ve uygun gözenek boyutu elde etmek amacıyla optimizasyon çalışmaları yapılmıştır. Elde edilen liflerin çapı, akış hızı ve voltajın artmasıyla azalmaktadır. Taramalı uç elektron mikroskop incelemeleri (SEM) lif morfolojik yapılarının doku iskelesi fabrikasyonu için ideale yakın olduğunu ortaya çıkarmıştır.
  • Book Part
    Citation - WoS: 21
    Citation - Scopus: 24
    Metals Foams for Biomedical Applications: Processing and Mechanical Properties
    (Springer, 2004) Güden, Mustafa; Çelik, Emrah; Çetiner, Sinan; Aydın, Alptekin
    Optimized structures found in nature can be sometimes imitated in engineering structures. The recent interest in functionally graded metallic materials makes bone structures interesting because bones are naturally functionally graded1. The cellular structure of foam metals (Fig.1) is very similar to that of the cancellous bone; therefore, these metals can be considered as potential candidates for future implant applications if porosity level, size and shape, strength and biocompatibility aspects satisfy the design specifications of implants. Foam metals based on biocompatible metallic materials (e.g. Ti and Ti-6A1-4V) are expected to provide better interaction with bone. This is mainly due to higher degree of bone growth into porous surfaces and higher degree of body fluid transport through three-dimensional interconnected array of pores2 (open cell foam), leading to better interlocking between implant and bone and hence reducing or avoiding the well-known implant losening. Furthermore, the elastic modulus of foam metals can be easily tailored with porosity level to match that of natural bone, leading to a better performance by avoiding the high degree of elastic mismatch which currently exists between conventional solid metallic implants and bone.