Master Degree / Yüksek Lisans Tezleri
Permanent URI for this collectionhttps://hdl.handle.net/11147/3008
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Master Thesis Desing and Synthesis of Bodipy Based Photosensitizers for Photodynamic Therapy(Izmir Institute of Technology, 2019) Dartar, Suay; Emrullahoğlu, Mustafa; Emrullahoğlu, MustafaPhotodynamic therapy is a promising modality for the non-invasive treatment of several cancerous and non-cancerous diseases. PDT is more preferable than other therapies due to its low damage to non-targeted tissues and its controllable characteristics. The therapy involves the activation of a photosensitizer under light illumination to generate singlet oxygen which is the cytotoxic agent employed against the cancerous tissues. Thus, there is currently a great effort to develop various photosensitizers. Among these, BODIPY based photosensitizers are distinguished due to certain characteristics, including excellent photostability, high extinction coefficients and high resistance to photobleaching. In this study, we aimed to synthesize and develop new BODIPY based photosensitizers for the use of photodynamic therapy agents. BODIPY skeleton was devised using the dibromoethylene unit from the 2,6-positions in order to enhance the π-conjugation system for red shift to longer wavelengths resulting in a deep penetration of tissue. Heavy atoms such as bromine were introduced to the BODIPY core to ensure the transition from singlet states to triplet states via intersystem crossing for the generation of singlet oxygen. Photophysical properties and spectroscopic measurements of photosensitizers were performed successfully. Finally the photodynamic activities of photosensitizers in cancerous cells were also investigated.Master Thesis Design and Synthesis of Bodipy Based Phosgene Sensor(Izmir Institute of Technology, 2018) Sayar, Melike; Emrullahoğlu, MustafaPhosgene was used in World War I as a chemical warfare agent and now, it is used as only a chemical intermediate in the industrial field according to laws. Because of the result of exposure to phosgene, its detection plays a significant role to protect civilians against terrorist attacks, and also to warn people if there would be any leakage in industrial facilities. To determine the phosgene, there are several methods like gas chromatography, which has several disadvantages such as poor portability and sensitivity and high cost or requiring of sophisticated procedures. However, fluorescence analysis has high sensitivity, resolution, and simplicity which provides real-time visual detection of analytes. For this thesis, boron-dipyrromethene (BODIPY) dye was used as the signal reporter by synthesizing the new BODIPY derivative, to benefit from its outstanding photophysical properties. In addition to that, as the main purpose of this thesis, this is the first time an o-aminobenzyl amine group was used due to be the phosgene-specific reactive motif for research in phosgene sensing which is an investigation of photophysical properties of designed BODIPY derivative in the absence and presence of phosgene.