Master Degree / Yüksek Lisans Tezleri
Permanent URI for this collectionhttps://hdl.handle.net/11147/3008
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Master Thesis Development and Characterization of Biomimetic Peptide-Based Bioink for Dental Tissue Engineering(01. Izmir Institute of Technology, 2023) Altan, Zeynep; Arslan Yıldız, AhuRecently, the role of molecular control in the tooth mineralization process has received much attention. Biomimetic scaffolds have been started to use in dental tissue engineering and regeneration due to their high applicability, biocompatibility, biodegradability, and mineralization capability. In this thesis, a hybrid biomimetic bio-ink; P11-4 peptide-based Quince Seed Hydrogel (QSH)/Gelatin (Gel) is used in 3D cell culture studies for dental tissue engineering applications. Pristine QSH, QSH/Gel, and P11-4/QSH/Gel bio-inks were characterized by FTIR and viscosity analysis, and their 3D bioprinting parameters were optimized. Hydrogels were crosslinked via 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) coupling reaction and various hydrogel concentrations were investigated for scaffold fabrication. Characterization of produced scaffolds was performed by SEM imaging, mechanical testing, protein adsorption, and swelling analyses. As a result, the mechanical strength, viscosity, swelling properties, and surface characteristics of the biomaterial were evaluated. SaOS-2 human osteosarcoma cell line was used for 3D bioprinting studies. Cell viability analyses were performed via Live/Dead and MTT assays. Mineralization was investigated and assay was carried out with Alizarin Red Staining. According to obtained results, P11-4/QSH/Gel scaffolds provide high cell viability and proliferation rate compared to pristine QSH and QSH/Gel control groups. Also, with the addition of P11-4 to QSH/Gel, a certain amount of increase in mineralization was observed after day 7 on long-term cultured scaffolds. As a result of this study, it was concluded that P11-4-based QSH/Gel has a high potential to be used as a bio-ink in the production of 3D scaffolds for dental tissue engineering applications.Master Thesis Use of Biomimicry in Industrial Design Education in Turkey: the Case of Izmir Universities(Izmir Institute of Technology, 2019) Avcı, Gamze; Tunç Fox, AyçaFrom the viewpoint of industrial design, industrial design education and practice, and designer's responsibility, sustainable design has gained great importance to solve the crisis of sustainability the world has faced today. Besides sustainability, innovation is an important element or task in today’s fast-changing economy. Thinking up new and fresh ideas to develop new products and services is a vital component for companies to stay competitive, provide financial benefits and to remain a successful business. At this point, the concept of biomimicry offers industrial designers a great potential in solving complex human problems by providing sustainable innovation in both their education and professional life. Biomimicry, defined in many different ways, can be considered as a discipline, an approach, a strategy, a method, or a tool. More importantly, biomimicry is applicable. This thesis aims to explore the state of biomimicry in Turkey and the world and to examine the awareness of students and academicians in industrial design education in Turkey. In this context, it first explains how the concept of biomimicry emerged, how it developed, its origins, its methodology, what it means and its relationships with sustainability and innovation. In addition, various examples and studies in the field of education and business regarding biomimicry as a discipline and as a practice have been given. Besides literature review, two surveys have been conducted with 10 industrial design instructors and 50 industrial design students to measure their awareness and to explain specifically how the concept of biomimicry has been conceived and applied in Turkey.